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Patent code US10947222

Compile Data Set for Download or QSAR
Found 72 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486396
PNG
(US10947222, Example 27-A)
Show SMILES FC(F)Oc1cccc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)N[C@H]1CCS(=O)(=O)C1
Show InChI InChI=1S/C26H21F3N2O4S/c27-18-5-7-20(8-6-18)31-14-23(16-2-1-3-21(12-16)35-26(28)29)22-9-4-17(13-24(22)31)25(32)30-19-10-11-36(33,34)15-19/h1-9,12-14,19,26H,10-11,15H2,(H,30,32)/t19-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486376
PNG
(3-(3-cyclopropylphenyl)-1-(5- fluoropyridin-2-yl)-...)
Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cn3)c2c1)-c1cccc(c1)C1CC1
Show InChI InChI=1S/C28H26FN3O3S/c1-28(11-12-36(34,35)17-28)31-27(33)21-7-9-23-24(20-4-2-3-19(13-20)18-5-6-18)16-32(25(23)14-21)26-10-8-22(29)15-30-26/h2-4,7-10,13-16,18H,5-6,11-12,17H2,1H3,(H,31,33)/t28-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486393
PNG
(3-(5-(difluoromethoxy)pyridin- 3-yl)-1-(4-fluoroph...)
Show SMILES CC1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cc3)c2c1)-c1cncc(OC(F)F)c1
Show InChI InChI=1S/C26H22F3N3O4S/c1-26(8-9-37(34,35)15-26)31-24(33)16-2-7-21-22(17-10-20(13-30-12-17)36-25(28)29)14-32(23(21)11-16)19-5-3-18(27)4-6-19/h2-7,10-14,25H,8-9,15H2,1H3,(H,31,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486375
PNG
(3-(3-cyclopropylphenyl)-1-(5- fluoropyridin-2-yl)-...)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cn3)c2c1)-c1cccc(c1)C1CC1
Show InChI InChI=1S/C28H26FN3O3S/c1-28(11-12-36(34,35)17-28)31-27(33)21-7-9-23-24(20-4-2-3-19(13-20)18-5-6-18)16-32(25(23)14-21)26-10-8-22(29)15-30-26/h2-4,7-10,13-16,18H,5-6,11-12,17H2,1H3,(H,31,33)/t28-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486386
PNG
(3-(3-(difluoromethoxy)phenyl)-1-(5- fluoropyrimidi...)
Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ncc(F)cn3)c2c1)-c1cccc(OC(F)F)c1
Show InChI InChI=1S/C25H21F3N4O4S/c1-25(7-8-37(34,35)14-25)31-22(33)16-5-6-19-20(15-3-2-4-18(9-15)36-23(27)28)13-32(21(19)10-16)24-29-11-17(26)12-30-24/h2-6,9-13,23H,7-8,14H2,1H3,(H,31,33)/t25-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486372
PNG
(3-(3-(difluoromethoxy)phenyl)-1-(5- fluoropyridin-...)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cn3)c2c1)-c1cccc(OC(F)F)c1
Show InChI InChI=1S/C26H22F3N3O4S/c1-26(9-10-37(34,35)15-26)31-24(33)17-5-7-20-21(16-3-2-4-19(11-16)36-25(28)29)14-32(22(20)12-17)23-8-6-18(27)13-30-23/h2-8,11-14,25H,9-10,15H2,1H3,(H,31,33)/t26-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486373
PNG
(3-(3-(difluoromethoxy)phenyl)-1-(5- fluoropyridin-...)
Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cn3)c2c1)-c1cccc(OC(F)F)c1
Show InChI InChI=1S/C26H22F3N3O4S/c1-26(9-10-37(34,35)15-26)31-24(33)17-5-7-20-21(16-3-2-4-19(11-16)36-25(28)29)14-32(22(20)12-17)23-8-6-18(27)13-30-23/h2-8,11-14,25H,9-10,15H2,1H3,(H,31,33)/t26-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486408
PNG
(3-[3-(difluoromethoxy)phenyl]-N- (1,1-dioxidotetra...)
Show SMILES FC(F)Oc1cccc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C26H21F3N2O4S/c27-18-5-7-20(8-6-18)31-14-23(16-2-1-3-21(12-16)35-26(28)29)22-9-4-17(13-24(22)31)25(32)30-19-10-11-36(33,34)15-19/h1-9,12-14,19,26H,10-11,15H2,(H,30,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486387
PNG
(3-(3-(difluoromethoxy)phenyl)-N-(1,1- dioxidotetra...)
Show SMILES FC(F)Oc1cccc(c1)-c1cn(-c2ncc(F)cn2)c2cc(ccc12)C(=O)N[C@H]1CCS(=O)(=O)C1
Show InChI InChI=1S/C24H19F3N4O4S/c25-16-10-28-24(29-11-16)31-12-20(14-2-1-3-18(8-14)35-23(26)27)19-5-4-15(9-21(19)31)22(32)30-17-6-7-36(33,34)13-17/h1-5,8-12,17,23H,6-7,13H2,(H,30,32)/t17-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486385
PNG
(3-(3-(difluoromethoxy)phenyl)-1-(5- fluoropyrimidi...)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ncc(F)cn3)c2c1)-c1cccc(OC(F)F)c1
Show InChI InChI=1S/C25H21F3N4O4S/c1-25(7-8-37(34,35)14-25)31-22(33)16-5-6-19-20(15-3-2-4-18(9-15)36-23(27)28)13-32(21(19)10-16)24-29-11-17(26)12-30-24/h2-6,9-13,23H,7-8,14H2,1H3,(H,31,33)/t25-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486377
PNG
(3-(3-(difluoromethoxy)phenyl)-N-(1,1- dioxidotetra...)
Show SMILES FC(F)Oc1cccc(c1)-c1cn(-c2ccc(F)cn2)c2cc(ccc12)C(=O)N[C@H]1CCS(=O)(=O)C1
Show InChI InChI=1S/C25H20F3N3O4S/c26-17-5-7-23(29-12-17)31-13-21(15-2-1-3-19(10-15)35-25(27)28)20-6-4-16(11-22(20)31)24(32)30-18-8-9-36(33,34)14-18/h1-7,10-13,18,25H,8-9,14H2,(H,30,32)/t18-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486374
PNG
(3-(3-cyclopropylphenyl)-N-(1,1- dioxidotetrahydrot...)
Show SMILES Fc1ccc(nc1)-n1cc(-c2cccc(c2)C2CC2)c2ccc(cc12)C(=O)N[C@H]1CCS(=O)(=O)C1
Show InChI InChI=1S/C27H24FN3O3S/c28-21-7-9-26(29-14-21)31-15-24(19-3-1-2-18(12-19)17-4-5-17)23-8-6-20(13-25(23)31)27(32)30-22-10-11-35(33,34)16-22/h1-3,6-9,12-15,17,22H,4-5,10-11,16H2,(H,30,32)/t22-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486416
PNG
(3-(3-cyclopropylphenyl)-N-(1,1- dioxidotetrahydrot...)
Show SMILES Fc1ccc(cc1)-n1cc(-c2cccc(c2)C2CC2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C28H25FN2O3S/c29-22-7-9-24(10-8-22)31-16-26(20-3-1-2-19(14-20)18-4-5-18)25-11-6-21(15-27(25)31)28(32)30-23-12-13-35(33,34)17-23/h1-3,6-11,14-16,18,23H,4-5,12-13,17H2,(H,30,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486382
PNG
(3-(3-cyclopropylphenyl)-1-(5- fluoropyrimidin-2-yl...)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ncc(F)cn3)c2c1)-c1cccc(c1)C1CC1
Show InChI InChI=1S/C27H25FN4O3S/c1-27(9-10-36(34,35)16-27)31-25(33)20-7-8-22-23(19-4-2-3-18(11-19)17-5-6-17)15-32(24(22)12-20)26-29-13-21(28)14-30-26/h2-4,7-8,11-15,17H,5-6,9-10,16H2,1H3,(H,31,33)/t27-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486394
PNG
(US10947222, Example 26-A)
Show SMILES Fc1ccc(cc1)-n1cc(-c2cccc(c2)C2CC2)c2ccc(cc12)C(=O)N[C@H]1CCS(=O)(=O)C1
Show InChI InChI=1S/C28H25FN2O3S/c29-22-7-9-24(10-8-22)31-16-26(20-3-1-2-19(14-20)18-4-5-18)25-11-6-21(15-27(25)31)28(32)30-23-12-13-35(33,34)17-23/h1-3,6-11,14-16,18,23H,4-5,12-13,17H2,(H,30,32)/t23-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486401
PNG
(US10947222, Example 32 | methyl 3-{6-[(1,1- dioxid...)
Show SMILES COC(=O)c1cccc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C27H23FN2O5S/c1-35-27(32)19-4-2-3-17(13-19)24-15-30(22-8-6-20(28)7-9-22)25-14-18(5-10-23(24)25)26(31)29-21-11-12-36(33,34)16-21/h2-10,13-15,21H,11-12,16H2,1H3,(H,29,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486384
PNG
(3-(3-cyclopropylphenyl)-N-(1,1- dioxidotetrahydrot...)
Show SMILES Fc1cnc(nc1)-n1cc(-c2cccc(c2)C2CC2)c2ccc(cc12)C(=O)N[C@H]1CCS(=O)(=O)C1
Show InChI InChI=1S/C26H23FN4O3S/c27-20-12-28-26(29-13-20)31-14-23(18-3-1-2-17(10-18)16-4-5-16)22-7-6-19(11-24(22)31)25(32)30-21-8-9-35(33,34)15-21/h1-3,6-7,10-14,16,21H,4-5,8-9,15H2,(H,30,32)/t21-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486402
PNG
(N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...)
Show SMILES COc1cccc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C26H23FN2O4S/c1-33-22-4-2-3-17(13-22)24-15-29(21-8-6-19(27)7-9-21)25-14-18(5-10-23(24)25)26(30)28-20-11-12-34(31,32)16-20/h2-10,13-15,20H,11-12,16H2,1H3,(H,28,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486354
PNG
(3-(2-chlorophenyl)-1-(4-fluorophenyl)- N-(3-methyl...)
Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C26H22ClFN2O3S/c1-26(12-13-34(32,33)16-26)29-25(31)17-6-11-21-22(20-4-2-3-5-23(20)27)15-30(24(21)14-17)19-9-7-18(28)8-10-19/h2-11,14-15H,12-13,16H2,1H3,(H,29,31)/t26-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486355
PNG
(3-(2-chlorophenyl)-1-(4-fluorophenyl)- N-(3-methyl...)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C26H22ClFN2O3S/c1-26(12-13-34(32,33)16-26)29-25(31)17-6-11-21-22(20-4-2-3-5-23(20)27)15-30(24(21)14-17)19-9-7-18(28)8-10-19/h2-11,14-15H,12-13,16H2,1H3,(H,29,31)/t26-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486352
PNG
(US10947222, Example 1)
Show SMILES CC1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C26H22ClFN2O3S/c1-26(12-13-34(32,33)16-26)29-25(31)17-6-11-21-22(20-4-2-3-5-23(20)27)15-30(24(21)14-17)19-9-7-18(28)8-10-19/h2-11,14-15H,12-13,16H2,1H3,(H,29,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486379
PNG
(3-(2-chlorophenyl)-1-(5-fluoropyridin- 2-yl)-N-(3-...)
Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cn3)c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C25H21ClFN3O3S/c1-25(10-11-34(32,33)15-25)29-24(31)16-6-8-19-20(18-4-2-3-5-21(18)26)14-30(22(19)12-16)23-9-7-17(27)13-28-23/h2-9,12-14H,10-11,15H2,1H3,(H,29,31)/t25-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486403
PNG
(N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...)
Show SMILES Cc1cccc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C26H23FN2O3S/c1-17-3-2-4-18(13-17)24-15-29(22-8-6-20(27)7-9-22)25-14-19(5-10-23(24)25)26(30)28-21-11-12-33(31,32)16-21/h2-10,13-15,21H,11-12,16H2,1H3,(H,28,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486415
PNG
(3-(3-cyanophenyl)-N-(1,1- dioxidotetrahydrothiophe...)
Show SMILES Fc1ccc(cc1)-n1cc(-c2cccc(c2)C#N)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C26H20FN3O3S/c27-20-5-7-22(8-6-20)30-15-24(18-3-1-2-17(12-18)14-28)23-9-4-19(13-25(23)30)26(31)29-21-10-11-34(32,33)16-21/h1-9,12-13,15,21H,10-11,16H2,(H,29,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486430
PNG
(N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...)
Show SMILES F[O](F)[F]#Cc1cccc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C26H20F4N2O4S/c27-20-5-7-22(8-6-20)32-15-24(18-3-1-2-17(12-18)14-30-36(28)29)23-9-4-19(13-25(23)32)26(33)31-21-10-11-37(34,35)16-21/h1-9,12-13,15,21H,10-11,16H2,(H,31,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486407
PNG
(N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...)
Show SMILES Fc1ccc(cc1)-n1cc(-c2cccc(c2)-n2cccn2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C28H23FN4O3S/c29-21-6-8-23(9-7-21)32-17-26(19-3-1-4-24(15-19)33-13-2-12-30-33)25-10-5-20(16-27(25)32)28(34)31-22-11-14-37(35,36)18-22/h1-10,12-13,15-17,22H,11,14,18H2,(H,31,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486378
PNG
(3-(2-chlorophenyl)-1-(5-fluoropyridin- 2-yl)-N-(3-...)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cn3)c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C25H21ClFN3O3S/c1-25(10-11-34(32,33)15-25)29-24(31)16-6-8-19-20(18-4-2-3-5-21(18)26)14-30(22(19)12-16)23-9-7-17(27)13-28-23/h2-9,12-14H,10-11,15H2,1H3,(H,29,31)/t25-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486397
PNG
(US10947222, Example 28)
Show SMILES Cc1c(-c2cccc(OC(F)F)c2)c2ccc(cc2n1-c1ccc(F)cc1)C(=O)NC1(C)CCS(=O)(=O)C1
Show InChI InChI=1S/C28H25F3N2O4S/c1-17-25(18-4-3-5-22(14-18)37-27(30)31)23-11-6-19(26(34)32-28(2)12-13-38(35,36)16-28)15-24(23)33(17)21-9-7-20(29)8-10-21/h3-11,14-15,27H,12-13,16H2,1-2H3,(H,32,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486399
PNG
(N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...)
Show SMILES Fc1ccc(cc1)-n1cc(-c2cccc(c2)C(F)(F)F)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C26H20F4N2O3S/c27-19-5-7-21(8-6-19)32-14-23(16-2-1-3-18(12-16)26(28,29)30)22-9-4-17(13-24(22)32)25(33)31-20-10-11-36(34,35)15-20/h1-9,12-14,20H,10-11,15H2,(H,31,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486414
PNG
(3-(2,3-dichlorophenyl)-N-(1,1- dioxidotetrahydroth...)
Show SMILES Fc1ccc(cc1)-n1cc(-c2cccc(Cl)c2Cl)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C25H19Cl2FN2O3S/c26-22-3-1-2-20(24(22)27)21-13-30(18-7-5-16(28)6-8-18)23-12-15(4-9-19(21)23)25(31)29-17-10-11-34(32,33)14-17/h1-9,12-13,17H,10-11,14H2,(H,29,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486410
PNG
(N-(1,1-dioxidotetrahydrothiophen- 3-yl)-3-(2-fluor...)
Show SMILES Fc1ccc(cc1)-n1cc(-c2ccccc2F)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C25H20F2N2O3S/c26-17-6-8-19(9-7-17)29-14-22(20-3-1-2-4-23(20)27)21-10-5-16(13-24(21)29)25(30)28-18-11-12-33(31,32)15-18/h1-10,13-14,18H,11-12,15H2,(H,28,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486381
PNG
(3-(2-chlorophenyl)-1-(5- fluoropyrimidin-2-yl)-N-(...)
Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ncc(F)cn3)c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C24H20ClFN4O3S/c1-24(8-9-34(32,33)14-24)29-22(31)15-6-7-18-19(17-4-2-3-5-20(17)25)13-30(21(18)10-15)23-27-11-16(26)12-28-23/h2-7,10-13H,8-9,14H2,1H3,(H,29,31)/t24-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486400
PNG
(3-(3-chlorophenyl)-N-(1,1- dioxidotetrahydrothioph...)
Show SMILES Fc1ccc(cc1)-n1cc(-c2cccc(Cl)c2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C25H20ClFN2O3S/c26-18-3-1-2-16(12-18)23-14-29(21-7-5-19(27)6-8-21)24-13-17(4-9-22(23)24)25(30)28-20-10-11-33(31,32)15-20/h1-9,12-14,20H,10-11,15H2,(H,28,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486358
PNG
(US10947222, Example 2-B)
Show SMILES Fc1ccc(cc1)-n1cc(-c2ccccc2Cl)c2ccc(cc12)C(=O)N[C@H]1CCS(=O)(=O)C1
Show InChI InChI=1S/C25H20ClFN2O3S/c26-23-4-2-1-3-20(23)22-14-29(19-8-6-17(27)7-9-19)24-13-16(5-10-21(22)24)25(30)28-18-11-12-33(31,32)15-18/h1-10,13-14,18H,11-12,15H2,(H,28,30)/t18-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486418
PNG
(3-(2,6-difluorophenyl)-N-(1,1- dioxidotetrahydroth...)
Show SMILES Fc1ccc(cc1)-n1cc(-c2c(F)cccc2F)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C25H19F3N2O3S/c26-16-5-7-18(8-6-16)30-13-20(24-21(27)2-1-3-22(24)28)19-9-4-15(12-23(19)30)25(31)29-17-10-11-34(32,33)14-17/h1-9,12-13,17H,10-11,14H2,(H,29,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486413
PNG
(N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...)
Show SMILES Fc1ccc(cc1)-n1cc(-c2ccccc2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C25H21FN2O3S/c26-19-7-9-21(10-8-19)28-15-23(17-4-2-1-3-5-17)22-11-6-18(14-24(22)28)25(29)27-20-12-13-32(30,31)16-20/h1-11,14-15,20H,12-13,16H2,(H,27,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486405
PNG
(3-biphenyl-3-yl-N-(1,1- dioxidotetrahydrothiophen-...)
Show SMILES Fc1ccc(cc1)-n1cc(-c2cccc(c2)-c2ccccc2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C31H25FN2O3S/c32-25-10-12-27(13-11-25)34-19-29(23-8-4-7-22(17-23)21-5-2-1-3-6-21)28-14-9-24(18-30(28)34)31(35)33-26-15-16-38(36,37)20-26/h1-14,17-19,26H,15-16,20H2,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486356
PNG
(US10947222, Example 2)
Show SMILES Fc1ccc(cc1)-n1cc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C25H20ClFN2O3S/c26-23-4-2-1-3-20(23)22-14-29(19-8-6-17(27)7-9-19)24-13-16(5-10-21(22)24)25(30)28-18-11-12-33(31,32)15-18/h1-10,13-14,18H,11-12,15H2,(H,28,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486380
PNG
(3-(2-chlorophenyl)-1-(5- fluoropyrimidin-2-yl)-N-(...)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ncc(F)cn3)c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C24H20ClFN4O3S/c1-24(8-9-34(32,33)14-24)29-22(31)15-6-7-18-19(17-4-2-3-5-20(17)25)13-30(21(18)10-15)23-27-11-16(26)12-28-23/h2-7,10-13H,8-9,14H2,1H3,(H,29,31)/t24-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486411
PNG
(3-(3,5-dichlorophenyl)-N-(1,1- dioxidotetrahydroth...)
Show SMILES Fc1ccc(cc1)-n1cc(-c2cc(Cl)cc(Cl)c2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C25H19Cl2FN2O3S/c26-17-9-16(10-18(27)12-17)23-13-30(21-4-2-19(28)3-5-21)24-11-15(1-6-22(23)24)25(31)29-20-7-8-34(32,33)14-20/h1-6,9-13,20H,7-8,14H2,(H,29,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486404
PNG
(N-(1,1-dioxidotetrahydrothiophen- 3-yl)-3-(3-fluor...)
Show SMILES Fc1ccc(cc1)-n1cc(-c2cccc(F)c2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C25H20F2N2O3S/c26-18-5-7-21(8-6-18)29-14-23(16-2-1-3-19(27)12-16)22-9-4-17(13-24(22)29)25(30)28-20-10-11-33(31,32)15-20/h1-9,12-14,20H,10-11,15H2,(H,28,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486422
PNG
(N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...)
Show SMILES Cn1ccc2cc(ccc12)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C28H24FN3O3S/c1-31-12-10-19-14-18(3-9-26(19)31)25-16-32(23-6-4-21(29)5-7-23)27-15-20(2-8-24(25)27)28(33)30-22-11-13-36(34,35)17-22/h2-10,12,14-16,22H,11,13,17H2,1H3,(H,30,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486412
PNG
(3-[2-(difluoromethoxy)phenyl]-N- (1,1-dioxidotetra...)
Show SMILES FC(F)Oc1ccccc1-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C26H21F3N2O4S/c27-17-6-8-19(9-7-17)31-14-22(21-3-1-2-4-24(21)35-26(28)29)20-10-5-16(13-23(20)31)25(32)30-18-11-12-36(33,34)15-18/h1-10,13-14,18,26H,11-12,15H2,(H,30,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486391
PNG
(N-(1,1- dioxidotetrahydrothiophen-3- yl)-1-(4-fluo...)
Show SMILES Cc1ccnc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C25H22FN3O3S/c1-16-8-10-27-23(12-16)22-14-29(20-5-3-18(26)4-6-20)24-13-17(2-7-21(22)24)25(30)28-19-9-11-33(31,32)15-19/h2-8,10,12-14,19H,9,11,15H2,1H3,(H,28,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486428
PNG
(N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...)
Show SMILES Fc1ccc(cc1)-n1cc(-c2ccc(cc2)-n2cccn2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C28H23FN4O3S/c29-21-5-9-23(10-6-21)32-17-26(19-2-7-24(8-3-19)33-14-1-13-30-33)25-11-4-20(16-27(25)32)28(34)31-22-12-15-37(35,36)18-22/h1-11,13-14,16-17,22H,12,15,18H2,(H,31,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486424
PNG
(N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...)
Show SMILES Fc1ccc(cc1)-n1cc(-c2cccnc2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C24H20FN3O3S/c25-18-4-6-20(7-5-18)28-14-22(17-2-1-10-26-13-17)21-8-3-16(12-23(21)28)24(29)27-19-9-11-32(30,31)15-19/h1-8,10,12-14,19H,9,11,15H2,(H,27,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486419
PNG
(3-(2-chloro-6-fluorophenyl)-N- (1,1-dioxidotetrahy...)
Show SMILES Fc1ccc(cc1)-n1cc(-c2c(F)cccc2Cl)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C25H19ClF2N2O3S/c26-21-2-1-3-22(28)24(21)20-13-30(18-7-5-16(27)6-8-18)23-12-15(4-9-19(20)23)25(31)29-17-10-11-34(32,33)14-17/h1-9,12-13,17H,10-11,14H2,(H,29,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486406
PNG
(3-[3-(acetylamino)phenyl]-N-(1,1- dioxidotetrahydr...)
Show SMILES CC(=O)Nc1cccc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C27H24FN3O4S/c1-17(32)29-21-4-2-3-18(13-21)25-15-31(23-8-6-20(28)7-9-23)26-14-19(5-10-24(25)26)27(33)30-22-11-12-36(34,35)16-22/h2-10,13-15,22H,11-12,16H2,1H3,(H,29,32)(H,30,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486357
PNG
(US10947222, Example 2-A)
Show SMILES Fc1ccc(cc1)-n1cc(-c2ccccc2Cl)c2ccc(cc12)C(=O)N[C@@H]1CCS(=O)(=O)C1
Show InChI InChI=1S/C25H20ClFN2O3S/c26-23-4-2-1-3-20(23)22-14-29(19-8-6-17(27)7-9-19)24-13-16(5-10-21(22)24)25(30)28-18-11-12-33(31,32)15-18/h1-10,13-14,18H,11-12,15H2,(H,28,30)/t18-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486432
PNG
(US10947222, Example 60 | methyl 4-{6-[(1,1- dioxid...)
Show SMILES COC(=O)c1cc(cs1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C25H21FN2O5S2/c1-33-25(30)23-11-16(13-34-23)21-12-28(19-5-3-17(26)4-6-19)22-10-15(2-7-20(21)22)24(29)27-18-8-9-35(31,32)14-18/h2-7,10-13,18H,8-9,14H2,1H3,(H,27,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486361
PNG
((S)-3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(2-hy...)
Show SMILES OC[C@@H](NC(=O)c1ccc2c(cn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C29H20ClF4N3O2/c30-24-4-2-1-3-21(24)23-15-37(20-9-7-19(31)8-10-20)26-13-17(5-11-22(23)26)28(39)36-25(16-38)18-6-12-27(35-14-18)29(32,33)34/h1-15,25,38H,16H2,(H,36,39)/t25-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486398
PNG
(US10947222, Example 29)
Show SMILES COc1ccccc1-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C26H23FN2O4S/c1-33-25-5-3-2-4-22(25)23-15-29(20-9-7-18(27)8-10-20)24-14-17(6-11-21(23)24)26(30)28-19-12-13-34(31,32)16-19/h2-11,14-15,19H,12-13,16H2,1H3,(H,28,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486371
PNG
(3-(2-chlorophenyl)-2-cyano-1-(4- fluorophenyl)-N-(...)
Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(c(C#N)n(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C27H21ClFN3O3S/c1-27(12-13-36(34,35)16-27)31-26(33)17-6-11-21-23(14-17)32(19-9-7-18(29)8-10-19)24(15-30)25(21)20-4-2-3-5-22(20)28/h2-11,14H,12-13,16H2,1H3,(H,31,33)/t27-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486389
PNG
(3-(4-chloropyridin-2-yl)-N- (1,1-dioxidotetrahydro...)
Show SMILES Fc1ccc(cc1)-n1cc(-c2cc(Cl)ccn2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C24H19ClFN3O3S/c25-16-7-9-27-22(12-16)21-13-29(19-4-2-17(26)3-5-19)23-11-15(1-6-20(21)23)24(30)28-18-8-10-33(31,32)14-18/h1-7,9,11-13,18H,8,10,14H2,(H,28,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486421
PNG
(N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...)
Show SMILES Fc1ccc(cc1)-n1cc(-c2cncnc2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C23H19FN4O3S/c24-17-2-4-19(5-3-17)28-12-21(16-10-25-14-26-11-16)20-6-1-15(9-22(20)28)23(29)27-18-7-8-32(30,31)13-18/h1-6,9-12,14,18H,7-8,13H2,(H,27,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486359
PNG
(3-(2-chlorophenyl)-1-(4-fluorophenyl)- N-(1-methox...)
Show SMILES COCC(C)NC(=O)c1ccc2c(cn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C25H22ClFN2O2/c1-16(15-31-2)28-25(30)17-7-12-21-22(20-5-3-4-6-23(20)26)14-29(24(21)13-17)19-10-8-18(27)9-11-19/h3-14,16H,15H2,1-2H3,(H,28,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486426
PNG
(N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...)
Show SMILES Cn1cc(cn1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C23H21FN4O3S/c1-27-12-16(11-25-27)21-13-28(19-5-3-17(24)4-6-19)22-10-15(2-7-20(21)22)23(29)26-18-8-9-32(30,31)14-18/h2-7,10-13,18H,8-9,14H2,1H3,(H,26,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486370
PNG
(3-(2-chlorophenyl)-2-cyano-1-(4- fluorophenyl)-N-(...)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(c(C#N)n(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C27H21ClFN3O3S/c1-27(12-13-36(34,35)16-27)31-26(33)17-6-11-21-23(14-17)32(19-9-7-18(29)8-10-19)24(15-30)25(21)20-4-2-3-5-22(20)28/h2-11,14H,12-13,16H2,1H3,(H,31,33)/t27-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486364
PNG
((S)-3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(1-(6...)
Show SMILES C[C@H](NC(=O)c1ccc2c(cn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C29H20ClF4N3O/c1-17(19-7-13-27(35-15-19)29(32,33)34)36-28(38)18-6-12-23-24(22-4-2-3-5-25(22)30)16-37(26(23)14-18)21-10-8-20(31)9-11-21/h2-17H,1H3,(H,36,38)/t17-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486431
PNG
(N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...)
Show SMILES Oc1cccc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C25H21FN2O4S/c26-18-5-7-20(8-6-18)28-14-23(16-2-1-3-21(29)12-16)22-9-4-17(13-24(22)28)25(30)27-19-10-11-33(31,32)15-19/h1-9,12-14,19,29H,10-11,15H2,(H,27,30)
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n/an/a 492n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486425
PNG
(3-(3,5-dimethylisoxazol-4-yl)-N- (1,1-dioxidotetra...)
Show SMILES Cc1noc(C)c1-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C24H22FN3O4S/c1-14-23(15(2)32-27-14)21-12-28(19-6-4-17(25)5-7-19)22-11-16(3-8-20(21)22)24(29)26-18-9-10-33(30,31)13-18/h3-8,11-12,18H,9-10,13H2,1-2H3,(H,26,29)
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n/an/a 502n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486429
PNG
(3-[4-(difluoromethoxy)phenyl]-N- (1,1-dioxidotetra...)
Show SMILES FC(F)Oc1ccc(cc1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C26H21F3N2O4S/c27-18-4-6-20(7-5-18)31-14-23(16-1-8-21(9-2-16)35-26(28)29)22-10-3-17(13-24(22)31)25(32)30-19-11-12-36(33,34)15-19/h1-10,13-14,19,26H,11-12,15H2,(H,30,32)
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n/an/a 562n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486392
PNG
(1-(4-fluorophenyl)-N-(3- methyl-1,1- dioxidotetrah...)
Show SMILES Cc1ccnc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1(C)CCS(=O)(=O)C1
Show InChI InChI=1S/C26H24FN3O3S/c1-17-9-11-28-23(13-17)22-15-30(20-6-4-19(27)5-7-20)24-14-18(3-8-21(22)24)25(31)29-26(2)10-12-34(32,33)16-26/h3-9,11,13-15H,10,12,16H2,1-2H3,(H,29,31)
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n/an/a 571n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486360
PNG
(3-(2-chlorophenyl)-1-(4-fluorophenyl)- N-(2-methyl...)
Show SMILES CC(C)(CN1CCOCC1)NC(=O)c1ccc2c(cn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C29H29ClFN3O2/c1-29(2,19-33-13-15-36-16-14-33)32-28(35)20-7-12-24-25(23-5-3-4-6-26(23)30)18-34(27(24)17-20)22-10-8-21(31)9-11-22/h3-12,17-18H,13-16,19H2,1-2H3,(H,32,35)
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n/an/a 629n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486390
PNG
(N-(1,1- dioxidotetrahydrothiophen-3- yl)-1-(4-fluo...)
Show SMILES Fc1ccc(cc1)-n1cc(-c2ccccn2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C24H20FN3O3S/c25-17-5-7-19(8-6-17)28-14-21(22-3-1-2-11-26-22)20-9-4-16(13-23(20)28)24(29)27-18-10-12-32(30,31)15-18/h1-9,11,13-14,18H,10,12,15H2,(H,27,29)
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n/an/a 664n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486365
PNG
((R)-3-(2-chlorophenyl)-1-(4- fluorophenyl)-N-(1-(6...)
Show SMILES C[C@@H](NC(=O)c1ccc2c(cn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C29H20ClF4N3O/c1-17(19-7-13-27(35-15-19)29(32,33)34)36-28(38)18-6-12-23-24(22-4-2-3-5-25(22)30)16-37(26(23)14-18)21-10-8-20(31)9-11-21/h2-17H,1H3,(H,36,38)/t17-/m1/s1
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n/an/a 671n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486367
PNG
(3-(2-chlorophenyl)-1-(4-fluorophenyl)- 2-methyl-N-...)
Show SMILES Cc1c(-c2ccccc2Cl)c2ccc(cc2n1-c1ccc(F)cc1)C(=O)N[C@@]1(C)CCS(=O)(=O)C1
Show InChI InChI=1S/C27H24ClFN2O3S/c1-17-25(21-5-3-4-6-23(21)28)22-12-7-18(26(32)30-27(2)13-14-35(33,34)16-27)15-24(22)31(17)20-10-8-19(29)9-11-20/h3-12,15H,13-14,16H2,1-2H3,(H,30,32)/t27-/m0/s1
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n/an/a 692n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486427
PNG
(N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...)
Show SMILES Cc1ccc(cc1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C26H23FN2O3S/c1-17-2-4-18(5-3-17)24-15-29(22-9-7-20(27)8-10-22)25-14-19(6-11-23(24)25)26(30)28-21-12-13-33(31,32)16-21/h2-11,14-15,21H,12-13,16H2,1H3,(H,28,30)
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n/an/a 696n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486388
PNG
(US10947222, Example 20)
Show SMILES Cc1cc(C)nc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C26H24FN3O3S/c1-16-11-17(2)28-24(12-16)23-14-30(21-6-4-19(27)5-7-21)25-13-18(3-8-22(23)25)26(31)29-20-9-10-34(32,33)15-20/h3-8,11-14,20H,9-10,15H2,1-2H3,(H,29,31)
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n/an/a 802n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486433
PNG
(3-[3-(3,5-dimethyl-1H-pyrazol-1- yl)phenyl]-N-(1,1...)
Show SMILES Cc1cc(C)n(n1)-c1cccc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C30H27FN4O3S/c1-19-14-20(2)35(33-19)26-5-3-4-21(15-26)28-17-34(25-9-7-23(31)8-10-25)29-16-22(6-11-27(28)29)30(36)32-24-12-13-39(37,38)18-24/h3-11,14-17,24H,12-13,18H2,1-2H3,(H,32,36)
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n/an/a 929n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486366
PNG
(3-(2-chlorophenyl)-1-(4-fluorophenyl)- 2-methyl-N-...)
Show SMILES Cc1c(-c2ccccc2Cl)c2ccc(cc2n1-c1ccc(F)cc1)C(=O)N[C@]1(C)CCS(=O)(=O)C1
Show InChI InChI=1S/C27H24ClFN2O3S/c1-17-25(21-5-3-4-6-23(21)28)22-12-7-18(26(32)30-27(2)13-14-35(33,34)16-27)15-24(22)31(17)20-10-8-19(29)9-11-20/h3-12,15H,13-14,16H2,1-2H3,(H,30,32)/t27-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486417
PNG
(3-(2,6-dichlorophenyl)-N-(1,1- dioxidotetrahydroth...)
Show SMILES Fc1ccc(cc1)-n1cc(-c2c(Cl)cccc2Cl)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C25H19Cl2FN2O3S/c26-21-2-1-3-22(27)24(21)20-13-30(18-7-5-16(28)6-8-18)23-12-15(4-9-19(20)23)25(31)29-17-10-11-34(32,33)14-17/h1-9,12-13,17H,10-11,14H2,(H,29,31)
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n/an/a 942n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%