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Patent code US10947226

Compile Data Set for Download or QSAR
Found 23 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM486469
PNG
(US10947226, Example 15)
Show SMILES CN1c2cc(=O)n(CC3CC3)cc2CC[C@H](NC(=O)c2ncn(Cc3ccccc3F)n2)C1=O
Show InChI InChI=1S/C24H25FN6O3/c1-29-20-10-21(32)30(11-15-6-7-15)12-17(20)8-9-19(24(29)34)27-23(33)22-26-14-31(28-22)13-16-4-2-3-5-18(16)25/h2-5,10,12,14-15,19H,6-9,11,13H2,1H3,(H,27,33)/t19-/m0/s1
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39n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Enzyme assay: The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is m...


US Patent US10947226 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM486459
PNG
(Method #6 | US10947226, Example 6)
Show SMILES CN1c2cc(=O)n(C)cc2CC[C@H](NC(=O)c2ncn(Cc3ccccc3F)n2)C1=O
Show InChI InChI=1S/C21H21FN6O3/c1-26-10-14-7-8-16(21(31)27(2)17(14)9-18(26)29)24-20(30)19-23-12-28(25-19)11-13-5-3-4-6-15(13)22/h3-6,9-10,12,16H,7-8,11H2,1-2H3,(H,24,30)/t16-/m0/s1
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49n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Enzyme assay: The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is m...


US Patent US10947226 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM486468
PNG
(US10947226, Example 14)
Show SMILES CN1c2cc(=O)n(CC3CC3)cc2CC[C@H](NC(=O)c2nc3CC[C@@H](c4ccccc4F)n3n2)C1=O
Show InChI InChI=1S/C26H27FN6O3/c1-31-21-12-23(34)32(13-15-6-7-15)14-16(21)8-9-19(26(31)36)28-25(35)24-29-22-11-10-20(33(22)30-24)17-4-2-3-5-18(17)27/h2-5,12,14-15,19-20H,6-11,13H2,1H3,(H,28,35)/t19-,20-/m0/s1
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56n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Enzyme assay: The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is m...


US Patent US10947226 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM486458
PNG
(Method #5 | US10947226, Example 5)
Show SMILES CN1c2cc(=O)n(C)cc2CC[C@H](NC(=O)c2ncn(Cc3ccccc3)n2)C1=O
Show InChI InChI=1S/C21H22N6O3/c1-25-12-15-8-9-16(21(30)26(2)17(15)10-18(25)28)23-20(29)19-22-13-27(24-19)11-14-6-4-3-5-7-14/h3-7,10,12-13,16H,8-9,11H2,1-2H3,(H,23,29)/t16-/m0/s1
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79n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Enzyme assay: The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is m...


US Patent US10947226 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM486467
PNG
(Method #13 | US10947226, Example 13)
Show SMILES CN1c2cc(=O)n(C)cc2CC[C@H](NC(=O)c2nc3CC[C@@H](c4ccccc4F)n3n2)C1=O
Show InChI InChI=1S/C23H23FN6O3/c1-28-12-13-7-8-16(23(33)29(2)18(13)11-20(28)31)25-22(32)21-26-19-10-9-17(30(19)27-21)14-5-3-4-6-15(14)24/h3-6,11-12,16-17H,7-10H2,1-2H3,(H,25,32)/t16-,17-/m0/s1
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81.1n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Enzyme assay: The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is m...


US Patent US10947226 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM486472
PNG
(US10947226, Example 18)
Show SMILES CCn1cc2CC[C@H](NC(=O)c3nc4CC[C@@H](c5ccccc5F)n4n3)C(=O)N(C)c2cc1=O
Show InChI InChI=1S/C24H25FN6O3/c1-3-30-13-14-8-9-17(24(34)29(2)19(14)12-21(30)32)26-23(33)22-27-20-11-10-18(31(20)28-22)15-6-4-5-7-16(15)25/h4-7,12-13,17-18H,3,8-11H2,1-2H3,(H,26,33)/t17-,18-/m0/s1
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110n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Enzyme assay: The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is m...


US Patent US10947226 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM486473
PNG
(US10947226, Example 19)
Show SMILES CCn1cc2CC[C@H](NC(=O)c3ncn(Cc4ccccc4F)n3)C(=O)N(C)c2cc1=O
Show InChI InChI=1S/C22H23FN6O3/c1-3-28-11-15-8-9-17(22(32)27(2)18(15)10-19(28)30)25-21(31)20-24-13-29(26-20)12-14-6-4-5-7-16(14)23/h4-7,10-11,13,17H,3,8-9,12H2,1-2H3,(H,25,31)/t17-/m0/s1
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110n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Enzyme assay: The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is m...


US Patent US10947226 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM486462
PNG
(Method #9 | US10947226, Example 9)
Show SMILES CN1c2cn(C)c(=O)cc2CC[C@H](NC(=O)c2ncn(Cc3ccccc3F)n2)C1=O
Show InChI InChI=1S/C21H21FN6O3/c1-26-11-17-13(9-18(26)29)7-8-16(21(31)27(17)2)24-20(30)19-23-12-28(25-19)10-14-5-3-4-6-15(14)22/h3-6,9,11-12,16H,7-8,10H2,1-2H3,(H,24,30)/t16-/m0/s1
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111n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Enzyme assay: The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is m...


US Patent US10947226 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM486455
PNG
(Method #2 | US10947226, Example 2)
Show SMILES CN1c2ccc(=O)n(C)c2CC[C@H](NC(=O)c2ncn(Cc3ccccc3F)n2)C1=O
Show InChI InChI=1S/C21H21FN6O3/c1-26-16-8-7-15(21(31)27(2)17(16)9-10-18(26)29)24-20(30)19-23-12-28(25-19)11-13-5-3-4-6-14(13)22/h3-6,9-10,12,15H,7-8,11H2,1-2H3,(H,24,30)/t15-/m0/s1
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156n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Enzyme assay: The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is m...


US Patent US10947226 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM486460
PNG
(Method #7 | US10947226, Example 7)
Show SMILES CN1c2cn(C)c(=O)cc2CC[C@H](NC(=O)c2ncn(Cc3ccccc3)n2)C1=O
Show InChI InChI=1S/C21H22N6O3/c1-25-12-17-15(10-18(25)28)8-9-16(21(30)26(17)2)23-20(29)19-22-13-27(24-19)11-14-6-4-3-5-7-14/h3-7,10,12-13,16H,8-9,11H2,1-2H3,(H,23,29)/t16-/m0/s1
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173n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Enzyme assay: The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is m...


US Patent US10947226 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM486464
PNG
(Method #11 | US10947226, Example 11)
Show SMILES CN1c2cn(C)c(=O)cc2CC[C@H](NC(=O)c2nc3CC[C@@H](c4ccccc4F)n3n2)C1=O
Show InChI InChI=1S/C23H23FN6O3/c1-28-12-18-13(11-20(28)31)7-8-16(23(33)29(18)2)25-22(32)21-26-19-10-9-17(30(19)27-21)14-5-3-4-6-15(14)24/h3-6,11-12,16-17H,7-10H2,1-2H3,(H,25,32)/t16-,17-/m0/s1
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231n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Enzyme assay: The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is m...


US Patent US10947226 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM486454
PNG
(Synthetic Method #1 | US10947226, Example 1)
Show SMILES CN1c2ccc(=O)n(C)c2CC[C@H](NC(=O)c2ncn(Cc3ccccc3)n2)C1=O
Show InChI InChI=1S/C21H22N6O3/c1-25-16-9-8-15(21(30)26(2)17(16)10-11-18(25)28)23-20(29)19-22-13-27(24-19)12-14-6-4-3-5-7-14/h3-7,10-11,13,15H,8-9,12H2,1-2H3,(H,23,29)/t15-/m0/s1
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233n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Enzyme assay: The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is m...


US Patent US10947226 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM486457
PNG
(Method #4 | US10947226, Example 4)
Show SMILES CN1c2cccc(=O)n2CC[C@H](NC(=O)c2ncn(Cc3ccccc3F)n2)C1=O
Show InChI InChI=1S/C20H19FN6O3/c1-25-16-7-4-8-17(28)27(16)10-9-15(20(25)30)23-19(29)18-22-12-26(24-18)11-13-5-2-3-6-14(13)21/h2-8,12,15H,9-11H2,1H3,(H,23,29)/t15-/m0/s1
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290n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Enzyme assay: The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is m...


US Patent US10947226 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM486456
PNG
(Method #3 | US10947226, Example 3)
Show SMILES CN1c2cccc(=O)n2CC[C@H](NC(=O)c2ncn(Cc3ccccc3)n2)C1=O
Show InChI InChI=1S/C20H20N6O3/c1-24-16-8-5-9-17(27)26(16)11-10-15(20(24)29)22-19(28)18-21-13-25(23-18)12-14-6-3-2-4-7-14/h2-9,13,15H,10-12H2,1H3,(H,22,28)/t15-/m0/s1
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489n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Enzyme assay: The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is m...


US Patent US10947226 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM486471
PNG
(US10947226, Example 17)
Show SMILES CN1c2cc(=O)n(CC3CC3)cc2CC[C@@H](NC(=O)c2ncn(Cc3ccccc3F)n2)C1=O
Show InChI InChI=1S/C24H25FN6O3/c1-29-20-10-21(32)30(11-15-6-7-15)12-17(20)8-9-19(24(29)34)27-23(33)22-26-14-31(28-22)13-16-4-2-3-5-18(16)25/h2-5,10,12,14-15,19H,6-9,11,13H2,1H3,(H,27,33)/t19-/m1/s1
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6.90E+3n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Enzyme assay: The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is m...


US Patent US10947226 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM486470
PNG
(US10947226, Example 16)
Show SMILES CN1c2cc(=O)n(CC3CC3)cc2CC[C@@H](NC(=O)c2nc3CC[C@@H](c4ccccc4F)n3n2)C1=O
Show InChI InChI=1S/C26H27FN6O3/c1-31-21-12-23(34)32(13-15-6-7-15)14-16(21)8-9-19(26(31)36)28-25(35)24-29-22-11-10-20(33(22)30-24)17-4-2-3-5-18(17)27/h2-5,12,14-15,19-20H,6-11,13H2,1H3,(H,28,35)/t19-,20+/m1/s1
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6.90E+3n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Enzyme assay: The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is m...


US Patent US10947226 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM486477
PNG
(US10947226, Example 23)
Show SMILES CN1c2ccc(=O)n(C)c2CC[C@@H](NC(=O)c2ncn(Cc3ccccc3)n2)C1=O
Show InChI InChI=1S/C21H22N6O3/c1-25-16-9-8-15(21(30)26(2)17(16)10-11-18(25)28)23-20(29)19-22-13-27(24-19)12-14-6-4-3-5-7-14/h3-7,10-11,13,15H,8-9,12H2,1-2H3,(H,23,29)/t15-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Enzyme assay: The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is m...


US Patent US10947226 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM486476
PNG
(US10947226, Example 22)
Show SMILES CN1c2ccc(=O)n(C)c2CC[C@@H](NC(=O)c2ncn(Cc3ccccc3F)n2)C1=O
Show InChI InChI=1S/C21H21FN6O3/c1-26-16-8-7-15(21(31)27(2)17(16)9-10-18(26)29)24-20(30)19-23-12-28(25-19)11-13-5-3-4-6-14(13)22/h3-6,9-10,12,15H,7-8,11H2,1-2H3,(H,24,30)/t15-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Enzyme assay: The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is m...


US Patent US10947226 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM486474
PNG
(US10947226, Example 20)
Show SMILES CCn1cc2CC[C@@H](NC(=O)c3nc4CC[C@@H](c5ccccc5F)n4n3)C(=O)N(C)c2cc1=O
Show InChI InChI=1S/C24H25FN6O3/c1-3-30-13-14-8-9-17(24(34)29(2)19(14)12-21(30)32)26-23(33)22-27-20-11-10-18(31(20)28-22)15-6-4-5-7-16(15)25/h4-7,12-13,17-18H,3,8-11H2,1-2H3,(H,26,33)/t17-,18+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Enzyme assay: The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is m...


US Patent US10947226 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM486461
PNG
(Method #8 | US10947226, Example 8)
Show SMILES CN1c2cn(C)c(=O)cc2CC[C@@H](NC(=O)c2ncn(Cc3ccccc3)n2)C1=O
Show InChI InChI=1S/C21H22N6O3/c1-25-12-17-15(10-18(25)28)8-9-16(21(30)26(17)2)23-20(29)19-22-13-27(24-19)11-14-6-4-3-5-7-14/h3-7,10,12-13,16H,8-9,11H2,1-2H3,(H,23,29)/t16-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Enzyme assay: The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is m...


US Patent US10947226 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM486475
PNG
(US10947226, Example 21)
Show SMILES CCn1cc2CC[C@@H](NC(=O)c3ncn(Cc4ccccc4F)n3)C(=O)N(C)c2cc1=O
Show InChI InChI=1S/C22H23FN6O3/c1-3-28-11-15-8-9-17(22(32)27(2)18(15)10-19(28)30)25-21(31)20-24-13-29(26-20)12-14-6-4-5-7-16(14)23/h4-7,10-11,13,17H,3,8-9,12H2,1-2H3,(H,25,31)/t17-/m1/s1
PDB

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antibodypedia
GoogleScholar
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Enzyme assay: The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is m...


US Patent US10947226 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM486466
PNG
(Method #12 | US10947226, Example 12)
Show SMILES CN1c2cn(C)c(=O)cc2CC[C@@H](NC(=O)c2nc3CC[C@@H](c4ccccc4F)n3n2)C1=O
Show InChI InChI=1S/C23H23FN6O3/c1-28-12-18-13(11-20(28)31)7-8-16(23(33)29(18)2)25-22(32)21-26-19-10-9-17(30(19)27-21)14-5-3-4-6-15(14)24/h3-6,11-12,16-17H,7-10H2,1-2H3,(H,25,32)/t16-,17+/m1/s1
PDB

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antibodypedia
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US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Enzyme assay: The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is m...


US Patent US10947226 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM486463
PNG
(Method #10 | US10947226, Example 10)
Show SMILES CN1c2cn(C)c(=O)cc2CC[C@@H](NC(=O)c2ncn(Cc3ccccc3F)n2)C1=O
Show InChI InChI=1S/C21H21FN6O3/c1-26-11-17-13(9-18(26)29)7-8-16(21(31)27(17)2)24-20(30)19-23-12-28(25-19)10-14-5-3-4-6-15(14)22/h3-6,9,11-12,16H,7-8,10H2,1-2H3,(H,24,30)/t16-/m1/s1
PDB

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antibodypedia
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US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Enzyme assay: The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is m...


US Patent US10947226 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%