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Patent code US10947234

Compile Data Set for Download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486486
PNG
(7-((1-acetylpiperidin-4-yl)amino)-4-ethyl-2-(2-hyd...)
Show SMILES CC[C@@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(NC3CCN(CC3)C(C)=O)ncc12
Show InChI InChI=1S/C28H37N5O3/c1-3-19-16-33(17-26(35)25-12-20-6-4-5-7-21(20)14-29-25)28(36)23-13-27(30-15-24(19)23)31-22-8-10-32(11-9-22)18(2)34/h4-7,13,15,19,22,25-26,29,35H,3,8-12,14,16-17H2,1-2H3,(H,30,31)/t19-,25+,26-/m1/s1
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n/an/a 1.08n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486489
PNG
(7-((1-acetylpiperidin-4-yl)amino)-2-(2-hydroxy-2-(...)
Show SMILES CC(=O)N1CCC(CC1)Nc1cc2C(=O)N(C[C@H](O)[C@@H]3Cc4ccccc4CN3)CC(C)(C)c2cn1
Show InChI InChI=1S/C28H37N5O3/c1-18(34)32-10-8-21(9-11-32)31-26-13-22-23(15-30-26)28(2,3)17-33(27(22)36)16-25(35)24-12-19-6-4-5-7-20(19)14-29-24/h4-7,13,15,21,24-25,29,35H,8-12,14,16-17H2,1-3H3,(H,30,31)/t24-,25-/m0/s1
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n/an/a 1.53n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486484
PNG
(7-((1-acetylpiperidin-4-yl)amino)-4-ethyl-2-(2-hyd...)
Show SMILES CC[C@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(NC3CCN(CC3)C(C)=O)ncc12
Show InChI InChI=1S/C28H37N5O3/c1-3-19-16-33(17-26(35)25-12-20-6-4-5-7-21(20)14-29-25)28(36)23-13-27(30-15-24(19)23)31-22-8-10-32(11-9-22)18(2)34/h4-7,13,15,19,22,25-26,29,35H,3,8-12,14,16-17H2,1-2H3,(H,30,31)/t19-,25-,26+/m0/s1
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n/an/a 7.15n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486482
PNG
(7-((1-acetylpiperidin-4-yl)amino)-2-(2-hydroxy-2-(...)
Show SMILES CC(=O)N1CCC(CC1)Nc1cc2C(=O)N(C[C@@H](O)[C@@H]3Cc4ccccc4CN3)CCc2cn1
Show InChI InChI=1S/C26H33N5O3/c1-17(32)30-10-7-21(8-11-30)29-25-13-22-20(15-28-25)6-9-31(26(22)34)16-24(33)23-12-18-4-2-3-5-19(18)14-27-23/h2-5,13,15,21,23-24,27,33H,6-12,14,16H2,1H3,(H,28,29)/t23-,24+/m0/s1
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n/an/a 10.8n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486488
PNG
(7-((1-acetylpiperidin-4-yl)amino)-2-(2-hydroxy-2-(...)
Show SMILES CC(=O)N1CCC(CC1)Nc1cc2C(=O)N(C[C@@H](O)[C@@H]3Cc4ccccc4CN3)CC(C)(C)c2cn1
Show InChI InChI=1S/C28H37N5O3/c1-18(34)32-10-8-21(9-11-32)31-26-13-22-23(15-30-26)28(2,3)17-33(27(22)36)16-25(35)24-12-19-6-4-5-7-20(19)14-29-24/h4-7,13,15,21,24-25,29,35H,8-12,14,16-17H2,1-3H3,(H,30,31)/t24-,25+/m0/s1
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n/an/a 56.9n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486485
PNG
(7-((1-acetylpiperidin-4-yl)amino)-4-ethyl-2-(2-hyd...)
Show SMILES CC[C@H]1CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(NC3CCN(CC3)C(C)=O)ncc12
Show InChI InChI=1S/C28H37N5O3/c1-3-19-16-33(17-26(35)25-12-20-6-4-5-7-21(20)14-29-25)28(36)23-13-27(30-15-24(19)23)31-22-8-10-32(11-9-22)18(2)34/h4-7,13,15,19,22,25-26,29,35H,3,8-12,14,16-17H2,1-2H3,(H,30,31)/t19-,25-,26-/m0/s1
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n/an/a 96.8n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486487
PNG
(7-((1-acetylpiperidin-4-yl)amino)-4-ethyl-2-(2-hyd...)
Show SMILES CC[C@@H]1CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(NC3CCN(CC3)C(C)=O)ncc12
Show InChI InChI=1S/C28H37N5O3/c1-3-19-16-33(17-26(35)25-12-20-6-4-5-7-21(20)14-29-25)28(36)23-13-27(30-15-24(19)23)31-22-8-10-32(11-9-22)18(2)34/h4-7,13,15,19,22,25-26,29,35H,3,8-12,14,16-17H2,1-2H3,(H,30,31)/t19-,25+,26+/m1/s1
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n/an/a 272n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486483
PNG
(7-((1-acetylpiperidin-4-yl)amino)-2-(2-hydroxy-2-(...)
Show SMILES CC(=O)N1CCC(CC1)Nc1cc2C(=O)N(C[C@H](O)[C@@H]3Cc4ccccc4CN3)CCc2cn1
Show InChI InChI=1S/C26H33N5O3/c1-17(32)30-10-7-21(8-11-30)29-25-13-22-20(15-28-25)6-9-31(26(22)34)16-24(33)23-12-18-4-2-3-5-19(18)14-27-23/h2-5,13,15,21,23-24,27,33H,6-12,14,16H2,1H3,(H,28,29)/t23-,24-/m0/s1
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n/an/a 482n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486489
PNG
(7-((1-acetylpiperidin-4-yl)amino)-2-(2-hydroxy-2-(...)
Show SMILES CC(=O)N1CCC(CC1)Nc1cc2C(=O)N(C[C@H](O)[C@@H]3Cc4ccccc4CN3)CC(C)(C)c2cn1
Show InChI InChI=1S/C28H37N5O3/c1-18(34)32-10-8-21(9-11-32)31-26-13-22-23(15-30-26)28(2,3)17-33(27(22)36)16-25(35)24-12-19-6-4-5-7-20(19)14-29-24/h4-7,13,15,21,24-25,29,35H,8-12,14,16-17H2,1-3H3,(H,30,31)/t24-,25-/m0/s1
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n/an/a 631n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486486
PNG
(7-((1-acetylpiperidin-4-yl)amino)-4-ethyl-2-(2-hyd...)
Show SMILES CC[C@@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(NC3CCN(CC3)C(C)=O)ncc12
Show InChI InChI=1S/C28H37N5O3/c1-3-19-16-33(17-26(35)25-12-20-6-4-5-7-21(20)14-29-25)28(36)23-13-27(30-15-24(19)23)31-22-8-10-32(11-9-22)18(2)34/h4-7,13,15,19,22,25-26,29,35H,3,8-12,14,16-17H2,1-2H3,(H,30,31)/t19-,25+,26-/m1/s1
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n/an/a 1.18E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486479
PNG
(7-chloro-4-ethyl-2-(2-hydroxy-2-((S)-1,2,3,4-tetra...)
Show SMILES CC[C@@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(Cl)ncc12
Show InChI InChI=1S/C21H24ClN3O2/c1-2-13-11-25(21(27)16-8-20(22)24-10-17(13)16)12-19(26)18-7-14-5-3-4-6-15(14)9-23-18/h3-6,8,10,13,18-19,23,26H,2,7,9,11-12H2,1H3/t13-,18+,19-/m1/s1
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n/an/a 3.84E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486484
PNG
(7-((1-acetylpiperidin-4-yl)amino)-4-ethyl-2-(2-hyd...)
Show SMILES CC[C@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(NC3CCN(CC3)C(C)=O)ncc12
Show InChI InChI=1S/C28H37N5O3/c1-3-19-16-33(17-26(35)25-12-20-6-4-5-7-21(20)14-29-25)28(36)23-13-27(30-15-24(19)23)31-22-8-10-32(11-9-22)18(2)34/h4-7,13,15,19,22,25-26,29,35H,3,8-12,14,16-17H2,1-2H3,(H,30,31)/t19-,25-,26+/m0/s1
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n/an/a 4.99E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486478
PNG
(7-chloro-4-ethyl-2-(2-hydroxy-2-((S)-1,2,3,4-tetra...)
Show SMILES CC[C@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(Cl)ncc12
Show InChI InChI=1S/C21H24ClN3O2/c1-2-13-11-25(21(27)16-8-20(22)24-10-17(13)16)12-19(26)18-7-14-5-3-4-6-15(14)9-23-18/h3-6,8,10,13,18-19,23,26H,2,7,9,11-12H2,1H3/t13-,18-,19+/m0/s1
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n/an/a 5.19E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486482
PNG
(7-((1-acetylpiperidin-4-yl)amino)-2-(2-hydroxy-2-(...)
Show SMILES CC(=O)N1CCC(CC1)Nc1cc2C(=O)N(C[C@@H](O)[C@@H]3Cc4ccccc4CN3)CCc2cn1
Show InChI InChI=1S/C26H33N5O3/c1-17(32)30-10-7-21(8-11-30)29-25-13-22-20(15-28-25)6-9-31(26(22)34)16-24(33)23-12-18-4-2-3-5-19(18)14-27-23/h2-5,13,15,21,23-24,27,33H,6-12,14,16H2,1H3,(H,28,29)/t23-,24+/m0/s1
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n/an/a 8.16E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486488
PNG
(7-((1-acetylpiperidin-4-yl)amino)-2-(2-hydroxy-2-(...)
Show SMILES CC(=O)N1CCC(CC1)Nc1cc2C(=O)N(C[C@@H](O)[C@@H]3Cc4ccccc4CN3)CC(C)(C)c2cn1
Show InChI InChI=1S/C28H37N5O3/c1-18(34)32-10-8-21(9-11-32)31-26-13-22-23(15-30-26)28(2,3)17-33(27(22)36)16-25(35)24-12-19-6-4-5-7-20(19)14-29-24/h4-7,13,15,21,24-25,29,35H,8-12,14,16-17H2,1-3H3,(H,30,31)/t24-,25+/m0/s1
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n/an/a 9.23E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486480
PNG
(7-chloro-4-ethyl-2-(2-hydroxy-2-((S)-1,2,3,4-tetra...)
Show SMILES CC[C@H]1CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(Cl)ncc12
Show InChI InChI=1S/C21H24ClN3O2/c1-2-13-11-25(21(27)16-8-20(22)24-10-17(13)16)12-19(26)18-7-14-5-3-4-6-15(14)9-23-18/h3-6,8,10,13,18-19,23,26H,2,7,9,11-12H2,1H3/t13-,18-,19-/m0/s1
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n/an/a 2.83E+4n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486485
PNG
(7-((1-acetylpiperidin-4-yl)amino)-4-ethyl-2-(2-hyd...)
Show SMILES CC[C@H]1CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(NC3CCN(CC3)C(C)=O)ncc12
Show InChI InChI=1S/C28H37N5O3/c1-3-19-16-33(17-26(35)25-12-20-6-4-5-7-21(20)14-29-25)28(36)23-13-27(30-15-24(19)23)31-22-8-10-32(11-9-22)18(2)34/h4-7,13,15,19,22,25-26,29,35H,3,8-12,14,16-17H2,1-2H3,(H,30,31)/t19-,25-,26-/m0/s1
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n/an/a 2.91E+4n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486481
PNG
(7-chloro-4-ethyl-2-(2-hydroxy-2-((S)-1,2,3,4-tetra...)
Show SMILES CC[C@@H]1CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(Cl)ncc12
Show InChI InChI=1S/C21H24ClN3O2/c1-2-13-11-25(21(27)16-8-20(22)24-10-17(13)16)12-19(26)18-7-14-5-3-4-6-15(14)9-23-18/h3-6,8,10,13,18-19,23,26H,2,7,9,11-12H2,1H3/t13-,18+,19+/m1/s1
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n/an/a 4.29E+4n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486487
PNG
(7-((1-acetylpiperidin-4-yl)amino)-4-ethyl-2-(2-hyd...)
Show SMILES CC[C@@H]1CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(NC3CCN(CC3)C(C)=O)ncc12
Show InChI InChI=1S/C28H37N5O3/c1-3-19-16-33(17-26(35)25-12-20-6-4-5-7-21(20)14-29-25)28(36)23-13-27(30-15-24(19)23)31-22-8-10-32(11-9-22)18(2)34/h4-7,13,15,19,22,25-26,29,35H,3,8-12,14,16-17H2,1-2H3,(H,30,31)/t19-,25+,26+/m1/s1
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n/an/a 6.45E+4n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486480
PNG
(7-chloro-4-ethyl-2-(2-hydroxy-2-((S)-1,2,3,4-tetra...)
Show SMILES CC[C@H]1CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(Cl)ncc12
Show InChI InChI=1S/C21H24ClN3O2/c1-2-13-11-25(21(27)16-8-20(22)24-10-17(13)16)12-19(26)18-7-14-5-3-4-6-15(14)9-23-18/h3-6,8,10,13,18-19,23,26H,2,7,9,11-12H2,1H3/t13-,18-,19-/m0/s1
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n/an/a 1.00E+5n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486481
PNG
(7-chloro-4-ethyl-2-(2-hydroxy-2-((S)-1,2,3,4-tetra...)
Show SMILES CC[C@@H]1CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(Cl)ncc12
Show InChI InChI=1S/C21H24ClN3O2/c1-2-13-11-25(21(27)16-8-20(22)24-10-17(13)16)12-19(26)18-7-14-5-3-4-6-15(14)9-23-18/h3-6,8,10,13,18-19,23,26H,2,7,9,11-12H2,1H3/t13-,18+,19+/m1/s1
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n/an/a 1.00E+5n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486478
PNG
(7-chloro-4-ethyl-2-(2-hydroxy-2-((S)-1,2,3,4-tetra...)
Show SMILES CC[C@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(Cl)ncc12
Show InChI InChI=1S/C21H24ClN3O2/c1-2-13-11-25(21(27)16-8-20(22)24-10-17(13)16)12-19(26)18-7-14-5-3-4-6-15(14)9-23-18/h3-6,8,10,13,18-19,23,26H,2,7,9,11-12H2,1H3/t13-,18-,19+/m0/s1
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n/an/a 1.00E+5n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486483
PNG
(7-((1-acetylpiperidin-4-yl)amino)-2-(2-hydroxy-2-(...)
Show SMILES CC(=O)N1CCC(CC1)Nc1cc2C(=O)N(C[C@H](O)[C@@H]3Cc4ccccc4CN3)CCc2cn1
Show InChI InChI=1S/C26H33N5O3/c1-17(32)30-10-7-21(8-11-30)29-25-13-22-20(15-28-25)6-9-31(26(22)34)16-24(33)23-12-18-4-2-3-5-19(18)14-27-23/h2-5,13,15,21,23-24,27,33H,6-12,14,16H2,1H3,(H,28,29)/t23-,24-/m0/s1
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n/an/a 1.00E+5n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486479
PNG
(7-chloro-4-ethyl-2-(2-hydroxy-2-((S)-1,2,3,4-tetra...)
Show SMILES CC[C@@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(Cl)ncc12
Show InChI InChI=1S/C21H24ClN3O2/c1-2-13-11-25(21(27)16-8-20(22)24-10-17(13)16)12-19(26)18-7-14-5-3-4-6-15(14)9-23-18/h3-6,8,10,13,18-19,23,26H,2,7,9,11-12H2,1H3/t13-,18+,19-/m1/s1
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n/an/a 1.00E+5n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486483
PNG
(7-((1-acetylpiperidin-4-yl)amino)-2-(2-hydroxy-2-(...)
Show SMILES CC(=O)N1CCC(CC1)Nc1cc2C(=O)N(C[C@H](O)[C@@H]3Cc4ccccc4CN3)CCc2cn1
Show InChI InChI=1S/C26H33N5O3/c1-17(32)30-10-7-21(8-11-30)29-25-13-22-20(15-28-25)6-9-31(26(22)34)16-24(33)23-12-18-4-2-3-5-19(18)14-27-23/h2-5,13,15,21,23-24,27,33H,6-12,14,16H2,1H3,(H,28,29)/t23-,24-/m0/s1
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n/an/an/an/a 1.00E+4n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The PRMT5 TE assay is a biomarker assay for identifying compounds that inhibit symmetric dimethylation of arginine (SDMA) of PRMT5 substrates. This a...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486484
PNG
(7-((1-acetylpiperidin-4-yl)amino)-4-ethyl-2-(2-hyd...)
Show SMILES CC[C@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(NC3CCN(CC3)C(C)=O)ncc12
Show InChI InChI=1S/C28H37N5O3/c1-3-19-16-33(17-26(35)25-12-20-6-4-5-7-21(20)14-29-25)28(36)23-13-27(30-15-24(19)23)31-22-8-10-32(11-9-22)18(2)34/h4-7,13,15,19,22,25-26,29,35H,3,8-12,14,16-17H2,1-2H3,(H,30,31)/t19-,25-,26+/m0/s1
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n/an/an/an/a 682n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The PRMT5 TE assay is a biomarker assay for identifying compounds that inhibit symmetric dimethylation of arginine (SDMA) of PRMT5 substrates. This a...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486482
PNG
(7-((1-acetylpiperidin-4-yl)amino)-2-(2-hydroxy-2-(...)
Show SMILES CC(=O)N1CCC(CC1)Nc1cc2C(=O)N(C[C@@H](O)[C@@H]3Cc4ccccc4CN3)CCc2cn1
Show InChI InChI=1S/C26H33N5O3/c1-17(32)30-10-7-21(8-11-30)29-25-13-22-20(15-28-25)6-9-31(26(22)34)16-24(33)23-12-18-4-2-3-5-19(18)14-27-23/h2-5,13,15,21,23-24,27,33H,6-12,14,16H2,1H3,(H,28,29)/t23-,24+/m0/s1
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n/an/an/an/a 1.59E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The PRMT5 TE assay is a biomarker assay for identifying compounds that inhibit symmetric dimethylation of arginine (SDMA) of PRMT5 substrates. This a...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486486
PNG
(7-((1-acetylpiperidin-4-yl)amino)-4-ethyl-2-(2-hyd...)
Show SMILES CC[C@@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(NC3CCN(CC3)C(C)=O)ncc12
Show InChI InChI=1S/C28H37N5O3/c1-3-19-16-33(17-26(35)25-12-20-6-4-5-7-21(20)14-29-25)28(36)23-13-27(30-15-24(19)23)31-22-8-10-32(11-9-22)18(2)34/h4-7,13,15,19,22,25-26,29,35H,3,8-12,14,16-17H2,1-2H3,(H,30,31)/t19-,25+,26-/m1/s1
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n/an/an/an/a 103n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The PRMT5 TE assay is a biomarker assay for identifying compounds that inhibit symmetric dimethylation of arginine (SDMA) of PRMT5 substrates. This a...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486479
PNG
(7-chloro-4-ethyl-2-(2-hydroxy-2-((S)-1,2,3,4-tetra...)
Show SMILES CC[C@@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(Cl)ncc12
Show InChI InChI=1S/C21H24ClN3O2/c1-2-13-11-25(21(27)16-8-20(22)24-10-17(13)16)12-19(26)18-7-14-5-3-4-6-15(14)9-23-18/h3-6,8,10,13,18-19,23,26H,2,7,9,11-12H2,1H3/t13-,18+,19-/m1/s1
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n/an/an/an/a 1.00E+4n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The PRMT5 TE assay is a biomarker assay for identifying compounds that inhibit symmetric dimethylation of arginine (SDMA) of PRMT5 substrates. This a...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486478
PNG
(7-chloro-4-ethyl-2-(2-hydroxy-2-((S)-1,2,3,4-tetra...)
Show SMILES CC[C@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(Cl)ncc12
Show InChI InChI=1S/C21H24ClN3O2/c1-2-13-11-25(21(27)16-8-20(22)24-10-17(13)16)12-19(26)18-7-14-5-3-4-6-15(14)9-23-18/h3-6,8,10,13,18-19,23,26H,2,7,9,11-12H2,1H3/t13-,18-,19+/m0/s1
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n/an/an/an/a 1.00E+4n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The PRMT5 TE assay is a biomarker assay for identifying compounds that inhibit symmetric dimethylation of arginine (SDMA) of PRMT5 substrates. This a...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486481
PNG
(7-chloro-4-ethyl-2-(2-hydroxy-2-((S)-1,2,3,4-tetra...)
Show SMILES CC[C@@H]1CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(Cl)ncc12
Show InChI InChI=1S/C21H24ClN3O2/c1-2-13-11-25(21(27)16-8-20(22)24-10-17(13)16)12-19(26)18-7-14-5-3-4-6-15(14)9-23-18/h3-6,8,10,13,18-19,23,26H,2,7,9,11-12H2,1H3/t13-,18+,19+/m1/s1
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n/an/an/an/a 1.00E+4n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The PRMT5 TE assay is a biomarker assay for identifying compounds that inhibit symmetric dimethylation of arginine (SDMA) of PRMT5 substrates. This a...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486485
PNG
(7-((1-acetylpiperidin-4-yl)amino)-4-ethyl-2-(2-hyd...)
Show SMILES CC[C@H]1CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(NC3CCN(CC3)C(C)=O)ncc12
Show InChI InChI=1S/C28H37N5O3/c1-3-19-16-33(17-26(35)25-12-20-6-4-5-7-21(20)14-29-25)28(36)23-13-27(30-15-24(19)23)31-22-8-10-32(11-9-22)18(2)34/h4-7,13,15,19,22,25-26,29,35H,3,8-12,14,16-17H2,1-2H3,(H,30,31)/t19-,25-,26-/m0/s1
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n/an/an/an/a 3.25E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The PRMT5 TE assay is a biomarker assay for identifying compounds that inhibit symmetric dimethylation of arginine (SDMA) of PRMT5 substrates. This a...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486480
PNG
(7-chloro-4-ethyl-2-(2-hydroxy-2-((S)-1,2,3,4-tetra...)
Show SMILES CC[C@H]1CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(Cl)ncc12
Show InChI InChI=1S/C21H24ClN3O2/c1-2-13-11-25(21(27)16-8-20(22)24-10-17(13)16)12-19(26)18-7-14-5-3-4-6-15(14)9-23-18/h3-6,8,10,13,18-19,23,26H,2,7,9,11-12H2,1H3/t13-,18-,19-/m0/s1
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n/an/an/an/a 1.00E+4n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The PRMT5 TE assay is a biomarker assay for identifying compounds that inhibit symmetric dimethylation of arginine (SDMA) of PRMT5 substrates. This a...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486489
PNG
(7-((1-acetylpiperidin-4-yl)amino)-2-(2-hydroxy-2-(...)
Show SMILES CC(=O)N1CCC(CC1)Nc1cc2C(=O)N(C[C@H](O)[C@@H]3Cc4ccccc4CN3)CC(C)(C)c2cn1
Show InChI InChI=1S/C28H37N5O3/c1-18(34)32-10-8-21(9-11-32)31-26-13-22-23(15-30-26)28(2,3)17-33(27(22)36)16-25(35)24-12-19-6-4-5-7-20(19)14-29-24/h4-7,13,15,21,24-25,29,35H,8-12,14,16-17H2,1-3H3,(H,30,31)/t24-,25-/m0/s1
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n/an/an/an/a 102n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The PRMT5 TE assay is a biomarker assay for identifying compounds that inhibit symmetric dimethylation of arginine (SDMA) of PRMT5 substrates. This a...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486487
PNG
(7-((1-acetylpiperidin-4-yl)amino)-4-ethyl-2-(2-hyd...)
Show SMILES CC[C@@H]1CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(NC3CCN(CC3)C(C)=O)ncc12
Show InChI InChI=1S/C28H37N5O3/c1-3-19-16-33(17-26(35)25-12-20-6-4-5-7-21(20)14-29-25)28(36)23-13-27(30-15-24(19)23)31-22-8-10-32(11-9-22)18(2)34/h4-7,13,15,19,22,25-26,29,35H,3,8-12,14,16-17H2,1-2H3,(H,30,31)/t19-,25+,26+/m1/s1
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n/an/an/an/a 1.00E+4n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The PRMT5 TE assay is a biomarker assay for identifying compounds that inhibit symmetric dimethylation of arginine (SDMA) of PRMT5 substrates. This a...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM486488
PNG
(7-((1-acetylpiperidin-4-yl)amino)-2-(2-hydroxy-2-(...)
Show SMILES CC(=O)N1CCC(CC1)Nc1cc2C(=O)N(C[C@@H](O)[C@@H]3Cc4ccccc4CN3)CC(C)(C)c2cn1
Show InChI InChI=1S/C28H37N5O3/c1-18(34)32-10-8-21(9-11-32)31-26-13-22-23(15-30-26)28(2,3)17-33(27(22)36)16-25(35)24-12-19-6-4-5-7-20(19)14-29-24/h4-7,13,15,21,24-25,29,35H,8-12,14,16-17H2,1-3H3,(H,30,31)/t24-,25+/m0/s1
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n/an/an/an/a 3.90E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The PRMT5 TE assay is a biomarker assay for identifying compounds that inhibit symmetric dimethylation of arginine (SDMA) of PRMT5 substrates. This a...


US Patent US10947234 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%