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Patent code US10947241

Compile Data Set for Download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Resistin


(Human)
BDBM486503
PNG
(US10947241, Example 46)
Show SMILES CNC1CCN(C1)c1nnc(-c2ccc(Cl)cc2)c2ccccc12
Show InChI InChI=1S/C19H19ClN4/c1-21-15-10-11-24(12-15)19-17-5-3-2-4-16(17)18(22-23-19)13-6-8-14(20)9-7-13/h2-9,15,21H,10-12H2,1H3
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486516
PNG
(US10947241, Example 91)
Show SMILES CNC1CCN(C1)c1nnc(-c2ccc(Cl)cc2)c2cc(F)ccc12
Show InChI InChI=1S/C19H18ClFN4/c1-22-15-8-9-25(11-15)19-16-7-6-14(21)10-17(16)18(23-24-19)12-2-4-13(20)5-3-12/h2-7,10,15,22H,8-9,11H2,1H3
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 600n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486504
PNG
(US10947241, Example 47)
Show SMILES CC(C)[C@H](N)C(=O)N1CCN(CC1)c1nnc(-c2ccc(Cl)cc2)c2ccccc12
Show InChI InChI=1S/C23H26ClN5O/c1-15(2)20(25)23(30)29-13-11-28(12-14-29)22-19-6-4-3-5-18(19)21(26-27-22)16-7-9-17(24)10-8-16/h3-10,15,20H,11-14,25H2,1-2H3/t20-/m0/s1
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 700n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486505
PNG
(US10947241, Example 51)
Show SMILES Clc1ccc(cc1)-c1nnc(N2CCN(CC2)C(=O)[C@H]2CCCN2)c2ccccc12
Show InChI InChI=1S/C23H24ClN5O/c24-17-9-7-16(8-10-17)21-18-4-1-2-5-19(18)22(27-26-21)28-12-14-29(15-13-28)23(30)20-6-3-11-25-20/h1-2,4-5,7-10,20,25H,3,6,11-15H2/t20-/m1/s1
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 800n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486515
PNG
(US10947241, Example 90)
Show SMILES CNC1CCN(C1)c1nnc(-c2ccc(Cl)cc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C19H18Cl2N4/c1-22-15-8-9-25(11-15)19-16-7-6-14(21)10-17(16)18(23-24-19)12-2-4-13(20)5-3-12/h2-7,10,15,22H,8-9,11H2,1H3
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 900n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486513
PNG
(US10947241, Example 88)
Show SMILES Clc1ccc(cc1)-c1nnc(N2CC3CCNC3C2)c2ccccc12
Show InChI InChI=1S/C20H19ClN4/c21-15-7-5-13(6-8-15)19-16-3-1-2-4-17(16)20(24-23-19)25-11-14-9-10-22-18(14)12-25/h1-8,14,18,22H,9-12H2
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 900n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486491
PNG
(US10947241, Example 1)
Show SMILES OCCN1CCN(CC1)c1nnc(-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C20H22N4O/c25-15-14-23-10-12-24(13-11-23)20-18-9-5-4-8-17(18)19(21-22-20)16-6-2-1-3-7-16/h1-9,25H,10-15H2
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.00E+3n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486507
PNG
(US10947241, Example 57)
Show SMILES CN[C@@H]1CCCN(C1)c1nnc(-c2ccc(Cl)cc2)c2ccccc12
Show InChI InChI=1S/C20H21ClN4/c1-22-16-5-4-12-25(13-16)20-18-7-3-2-6-17(18)19(23-24-20)14-8-10-15(21)11-9-14/h2-3,6-11,16,22H,4-5,12-13H2,1H3/t16-/m1/s1
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.00E+3n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486497
PNG
(US10947241, Example 10)
Show SMILES Clc1ccc(cc1)-c1nnc(N2CCN(CC2)C(=O)C2CC2)c2ccccc12
Show InChI InChI=1S/C22H21ClN4O/c23-17-9-7-15(8-10-17)20-18-3-1-2-4-19(18)21(25-24-20)26-11-13-27(14-12-26)22(28)16-5-6-16/h1-4,7-10,16H,5-6,11-14H2
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.20E+3n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486501
PNG
(US10947241, Example 43)
Show SMILES CC(C)(N)C(=O)N1CCN(CC1)c1nnc(-c2ccc(Cl)cc2)c2ccccc12
Show InChI InChI=1S/C22H24ClN5O/c1-22(2,24)21(29)28-13-11-27(12-14-28)20-18-6-4-3-5-17(18)19(25-26-20)15-7-9-16(23)10-8-15/h3-10H,11-14,24H2,1-2H3
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.30E+3n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486495
PNG
(US10947241, Example 4)
Show SMILES OCCC1CCN(CC1)c1nnc(-c2ccc(Cl)cc2)c2ccccc12
Show InChI InChI=1S/C21H22ClN3O/c22-17-7-5-16(6-8-17)20-18-3-1-2-4-19(18)21(24-23-20)25-12-9-15(10-13-25)11-14-26/h1-8,15,26H,9-14H2
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.60E+3n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486502
PNG
(US10947241, Example 45)
Show SMILES CC(=O)NC1CCN(C1)c1nnc(-c2ccc(Cl)cc2)c2ccccc12
Show InChI InChI=1S/C20H19ClN4O/c1-13(26)22-16-10-11-25(12-16)20-18-5-3-2-4-17(18)19(23-24-20)14-6-8-15(21)9-7-14/h2-9,16H,10-12H2,1H3,(H,22,26)
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.60E+3n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486512
PNG
(US10947241, Example 87)
Show SMILES Clc1ccc(cc1)-c1nnc(N2CCC3CCNC3C2)c2ccccc12
Show InChI InChI=1S/C21H21ClN4/c22-16-7-5-15(6-8-16)20-17-3-1-2-4-18(17)21(25-24-20)26-12-10-14-9-11-23-19(14)13-26/h1-8,14,19,23H,9-13H2
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.70E+3n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486514
PNG
(US10947241, Example 89)
Show SMILES CNC1CCN(C1)c1nnc(-c2ccc(Cl)cc2)c2ccc(Cl)cc12
Show InChI InChI=1S/C19H18Cl2N4/c1-22-15-8-9-25(11-15)19-17-10-14(21)6-7-16(17)18(23-24-19)12-2-4-13(20)5-3-12/h2-7,10,15,22H,8-9,11H2,1H3
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.80E+3n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486506
PNG
(US10947241, Example 54)
Show SMILES CCNC1CCN(C1)c1nnc(-c2ccc(Cl)cc2)c2ccccc12
Show InChI InChI=1S/C20H21ClN4/c1-2-22-16-11-12-25(13-16)20-18-6-4-3-5-17(18)19(23-24-20)14-7-9-15(21)10-8-14/h3-10,16,22H,2,11-13H2,1H3
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.90E+3n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486509
PNG
(US10947241, Example 60)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N1CCN(CC1)c1nnc(-c2ccc(Cl)cc2)c2ccccc12
Show InChI InChI=1S/C24H28ClN5O/c1-3-16(2)21(26)24(31)30-14-12-29(13-15-30)23-20-7-5-4-6-19(20)22(27-28-23)17-8-10-18(25)11-9-17/h4-11,16,21H,3,12-15,26H2,1-2H3/t16-,21-/m0/s1
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.90E+3n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486517
PNG
(US10947241, Example 93)
Show SMILES CNC1CCN(C1)c1nnc(Oc2ccc(Cl)cc2)c2ccccc12
Show InChI InChI=1S/C19H19ClN4O/c1-21-14-10-11-24(12-14)18-16-4-2-3-5-17(16)19(23-22-18)25-15-8-6-13(20)7-9-15/h2-9,14,21H,10-12H2,1H3
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.90E+3n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486518
PNG
(US10947241, Example 95)
Show SMILES Clc1ccc(cc1)-c1nnc(O[C@H]2CCNC2)c2ccccc12
Show InChI InChI=1S/C18H16ClN3O/c19-13-7-5-12(6-8-13)17-15-3-1-2-4-16(15)18(22-21-17)23-14-9-10-20-11-14/h1-8,14,20H,9-11H2/t14-/m0/s1
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 2.30E+3n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486499
PNG
(US10947241, Example 36)
Show SMILES C[C@@H](N)C(=O)N1CCN(CC1)c1nnc(-c2ccc(Cl)cc2)c2ccccc12
Show InChI InChI=1S/C21H22ClN5O/c1-14(23)21(28)27-12-10-26(11-13-27)20-18-5-3-2-4-17(18)19(24-25-20)15-6-8-16(22)9-7-15/h2-9,14H,10-13,23H2,1H3/t14-/m1/s1
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 2.50E+3n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486508
PNG
(US10947241, Example 58)
Show SMILES NC1(CCCC1)C(=O)N1CCN(CC1)c1nnc(-c2ccc(Cl)cc2)c2ccccc12
Show InChI InChI=1S/C24H26ClN5O/c25-18-9-7-17(8-10-18)21-19-5-1-2-6-20(19)22(28-27-21)29-13-15-30(16-14-29)23(31)24(26)11-3-4-12-24/h1-2,5-10H,3-4,11-16,26H2
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 2.90E+3n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486498
PNG
(US10947241, Example 34)
Show SMILES Clc1ccc(cc1)-c1nnc(N2CCN(CC2)S(=O)(=O)C2CCCC2)c2ccccc12
Show InChI InChI=1S/C23H25ClN4O2S/c24-18-11-9-17(10-12-18)22-20-7-3-4-8-21(20)23(26-25-22)27-13-15-28(16-14-27)31(29,30)19-5-1-2-6-19/h3-4,7-12,19H,1-2,5-6,13-16H2
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 3.00E+3n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486496
PNG
(US10947241, Example 9)
Show SMILES COCCN1CCN(CC1)c1nnc(-c2ccc(Cl)cc2)c2ccccc12
Show InChI InChI=1S/C21H23ClN4O/c1-27-15-14-25-10-12-26(13-11-25)21-19-5-3-2-4-18(19)20(23-24-21)16-6-8-17(22)9-7-16/h2-9H,10-15H2,1H3
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 3.70E+3n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486492
PNG
(US10947241, Example 2)
Show SMILES CC(=O)N1CCN(CC1)c1nnc(-c2ccc(C)cc2)c2ccccc12
Show InChI InChI=1S/C21H22N4O/c1-15-7-9-17(10-8-15)20-18-5-3-4-6-19(18)21(23-22-20)25-13-11-24(12-14-25)16(2)26/h3-10H,11-14H2,1-2H3
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 5.00E+3n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486510
PNG
(US10947241, Example 85)
Show SMILES NC(CC(N)=O)C(=O)N1CCN(CC1)c1nnc(-c2ccc(Cl)cc2)c2ccccc12
Show InChI InChI=1S/C22H23ClN6O2/c23-15-7-5-14(6-8-15)20-16-3-1-2-4-17(16)21(27-26-20)28-9-11-29(12-10-28)22(31)18(24)13-19(25)30/h1-8,18H,9-13,24H2,(H2,25,30)
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 5.40E+3n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486500
PNG
(US10947241, Example 38)
Show SMILES NCCN1CCN(CC1)c1nnc(-c2ccc(Cl)cc2)c2ccccc12
Show InChI InChI=1S/C20H22ClN5/c21-16-7-5-15(6-8-16)19-17-3-1-2-4-18(17)20(24-23-19)26-13-11-25(10-9-22)12-14-26/h1-8H,9-14,22H2
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 7.90E+3n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486511
PNG
(US10947241, Example 86)
Show SMILES NC(CCC(O)=O)C(=O)N1CCN(CC1)c1nnc(-c2ccc(Cl)cc2)c2ccccc12
Show InChI InChI=1S/C23H24ClN5O3/c24-16-7-5-15(6-8-16)21-17-3-1-2-4-18(17)22(27-26-21)28-11-13-29(14-12-28)23(32)19(25)9-10-20(30)31/h1-8,19H,9-14,25H2,(H,30,31)
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.80E+4n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%