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Patent code US10947251

Compile Data Set for Download or QSAR
Found 76 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486520
PNG
(US10947251, Example 2)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H21F5N4O6S/c1-37-20-9-14(13-2-3-16(25)15(8-13)24(27,28)29)17(26)10-19(20)33-18-4-6-32(11-21(18)38-12-23(33)34)40(35,36)31-22-5-7-39-30-22/h2-3,5,7-10,18,21H,4,6,11-12H2,1H3,(H,30,31)/t18-,21-/m0/s1
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n/an/a 0.915n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486519
PNG
(2 | US10947251, Example 1)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H21F5N4O6S/c1-37-20-9-14(13-2-3-16(25)15(8-13)24(27,28)29)17(26)10-19(20)33-18-4-6-32(11-21(18)38-12-23(33)34)40(35,36)31-22-5-7-39-30-22/h2-3,5,7-10,18,21H,4,6,11-12H2,1H3,(H,30,31)/t18-,21-/m1/s1
PDB

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n/an/a 1.12n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486524
PNG
(US10947251, Example 6)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C24H21F5N4O6S/c1-37-20-9-16(13-6-14(24(27,28)29)8-15(25)7-13)17(26)10-19(20)33-18-2-4-32(11-21(18)38-12-23(33)34)40(35,36)31-22-3-5-39-30-22/h3,5-10,18,21H,2,4,11-12H2,1H3,(H,30,31)/t18-,21-/m0/s1
PDB

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n/an/a 1.84n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486550
PNG
(28 | US10947251, Example 27)
Show SMILES COc1cc(c(F)cc1N1CCO[C@@H]2CN(CC[C@@H]12)S(=O)(=O)Nc1ccncn1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H25F4N5O4S/c1-37-22-12-18(16-3-2-4-17(11-16)25(27,28)29)19(26)13-21(22)34-9-10-38-23-14-33(8-6-20(23)34)39(35,36)32-24-5-7-30-15-31-24/h2-5,7,11-13,15,20,23H,6,8-10,14H2,1H3,(H,30,31,32)/t20-,23-/m1/s1
PDB

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n/an/a 2.02n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486551
PNG
(US10947251, Example 28)
Show SMILES COc1cc(c(F)cc1N1CCO[C@H]2CN(CC[C@H]12)S(=O)(=O)Nc1ccncn1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H25F4N5O4S/c1-37-22-12-18(16-3-2-4-17(11-16)25(27,28)29)19(26)13-21(22)34-9-10-38-23-14-33(8-6-20(23)34)39(35,36)32-24-5-7-30-15-31-24/h2-5,7,11-13,15,20,23H,6,8-10,14H2,1H3,(H,30,31,32)/t20-,23-/m0/s1
PDB

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n/an/a 2.10n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486564
PNG
(US10947251, Example 36)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@@H]2CCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H24F4N4O5S/c1-37-22-12-18(15-3-2-4-17(11-15)25(27,28)29)19(26)13-21(22)33-20-7-9-32(14-16(20)5-6-24(33)34)39(35,36)31-23-8-10-38-30-23/h2-4,8,10-13,16,20H,5-7,9,14H2,1H3,(H,30,31)/t16-,20+/m0/s1
PDB

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n/an/a 2.19n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486556
PNG
(30 | US10947251, Example 29)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H22F4N4O7S/c1-36-20-10-16(14-3-2-4-15(9-14)39-24(26,27)28)17(25)11-19(20)32-18-5-7-31(12-21(18)37-13-23(32)33)40(34,35)30-22-6-8-38-29-22/h2-4,6,8-11,18,21H,5,7,12-13H2,1H3,(H,29,30)/t18-,21-/m1/s1
PDB

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n/an/a 2.21n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486521
PNG
(4 | US10947251, Example 3)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H22F4N4O6S/c1-36-20-10-16(14-3-2-4-15(9-14)24(26,27)28)17(25)11-19(20)32-18-5-7-31(12-21(18)37-13-23(32)33)39(34,35)30-22-6-8-38-29-22/h2-4,6,8-11,18,21H,5,7,12-13H2,1H3,(H,29,30)/t18-,21-/m1/s1
PDB

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n/an/a 2.26n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486557
PNG
(US10947251, Example 30)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H22F4N4O7S/c1-36-20-10-16(14-3-2-4-15(9-14)39-24(26,27)28)17(25)11-19(20)32-18-5-7-31(12-21(18)37-13-23(32)33)40(34,35)30-22-6-8-38-29-22/h2-4,6,8-11,18,21H,5,7,12-13H2,1H3,(H,29,30)/t18-,21-/m0/s1
PDB

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n/an/a 2.35n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486548
PNG
(26 | US10947251, Example 25)
Show SMILES COc1cc(c(F)cc1N1CCO[C@@H]2CN(CC[C@@H]12)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H24F4N4O5S/c1-35-21-12-17(15-3-2-4-16(11-15)24(26,27)28)18(25)13-20(21)32-8-10-36-22-14-31(7-5-19(22)32)38(33,34)30-23-6-9-37-29-23/h2-4,6,9,11-13,19,22H,5,7-8,10,14H2,1H3,(H,29,30)/t19-,22-/m1/s1
PDB

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n/an/a 2.36n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486523
PNG
(6 | US10947251, Example 5)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C24H21F5N4O6S/c1-37-20-9-16(13-6-14(24(27,28)29)8-15(25)7-13)17(26)10-19(20)33-18-2-4-32(11-21(18)38-12-23(33)34)40(35,36)31-22-3-5-39-30-22/h3,5-10,18,21H,2,4,11-12H2,1H3,(H,30,31)/t18-,21-/m1/s1
PDB

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n/an/a 2.79n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486563
PNG
(US10947251, Example 35)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@H]2CCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H24F4N4O5S/c1-37-22-12-18(15-3-2-4-17(11-15)25(27,28)29)19(26)13-21(22)33-20-7-9-32(14-16(20)5-6-24(33)34)39(35,36)31-23-8-10-38-30-23/h2-4,8,10-13,16,20H,5-7,9,14H2,1H3,(H,30,31)/t16-,20-/m1/s1
PDB

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n/an/a 2.88n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486522
PNG
(US10947251, Example 4)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H22F4N4O6S/c1-36-20-10-16(14-3-2-4-15(9-14)24(26,27)28)17(25)11-19(20)32-18-5-7-31(12-21(18)37-13-23(32)33)39(34,35)30-22-6-8-38-29-22/h2-4,6,8-11,18,21H,5,7,12-13H2,1H3,(H,29,30)/t18-,21-/m0/s1
PDB

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n/an/a 3.52n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486526
PNG
(US10947251, Example 8)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cc(ccc1F)C(F)(F)F
Show InChI InChI=1S/C24H21F5N4O6S/c1-37-20-9-15(14-8-13(24(27,28)29)2-3-16(14)25)17(26)10-19(20)33-18-4-6-32(11-21(18)38-12-23(33)34)40(35,36)31-22-5-7-39-30-22/h2-3,5,7-10,18,21H,4,6,11-12H2,1H3,(H,30,31)/t18-,21-/m0/s1
PDB

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n/an/a 4.92n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486525
PNG
(8 | US10947251, Example 7)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cc(ccc1F)C(F)(F)F
Show InChI InChI=1S/C24H21F5N4O6S/c1-37-20-9-15(14-8-13(24(27,28)29)2-3-16(14)25)17(26)10-19(20)33-18-4-6-32(11-21(18)38-12-23(33)34)40(35,36)31-22-5-7-39-30-22/h2-3,5,7-10,18,21H,4,6,11-12H2,1H3,(H,30,31)/t18-,21-/m1/s1
PDB

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n/an/a 5.76n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486541
PNG
(US10947251, Example 18)
Show SMILES COc1cc(ccc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H23F3N4O6S/c1-35-20-12-16(15-3-2-4-17(11-15)24(25,26)27)5-6-18(20)31-19-7-9-30(13-21(19)36-14-23(31)32)38(33,34)29-22-8-10-37-28-22/h2-6,8,10-12,19,21H,7,9,13-14H2,1H3,(H,28,29)/t19-,21-/m0/s1
PDB

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n/an/a 5.86n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486558
PNG
(32 | US10947251, Example 31)
Show SMILES COc1cc(c(F)cc1N1CCO[C@@H]2CN(CC[C@@H]12)S(=O)(=O)Nc1ccon1)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H24F4N4O6S/c1-35-21-12-17(15-3-2-4-16(11-15)38-24(26,27)28)18(25)13-20(21)32-8-10-36-22-14-31(7-5-19(22)32)39(33,34)30-23-6-9-37-29-23/h2-4,6,9,11-13,19,22H,5,7-8,10,14H2,1H3,(H,29,30)/t19-,22-/m1/s1
PDB

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n/an/a 5.98n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486540
PNG
(18 | US10947251, Example 17)
Show SMILES COc1cc(ccc1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H23F3N4O6S/c1-35-20-12-16(15-3-2-4-17(11-15)24(25,26)27)5-6-18(20)31-19-7-9-30(13-21(19)36-14-23(31)32)38(33,34)29-22-8-10-37-28-22/h2-6,8,10-12,19,21H,7,9,13-14H2,1H3,(H,28,29)/t19-,21-/m1/s1
PDB

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n/an/a 6.03n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486535
PNG
(US10947251, Example 12)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C24H21F5N4O6S/c1-37-19-9-14(13-3-2-4-15(23(13)26)24(27,28)29)16(25)10-18(19)33-17-5-7-32(11-20(17)38-12-22(33)34)40(35,36)31-21-6-8-39-30-21/h2-4,6,8-10,17,20H,5,7,11-12H2,1H3,(H,30,31)/t17-,20-/m0/s1
PDB

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n/an/a 6.83n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486537
PNG
(US10947251, Example 14)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(Cl)c1
Show InChI InChI=1S/C23H22ClFN4O6S/c1-33-20-10-16(14-3-2-4-15(24)9-14)17(25)11-19(20)29-18-5-7-28(12-21(18)34-13-23(29)30)36(31,32)27-22-6-8-35-26-22/h2-4,6,8-11,18,21H,5,7,12-13H2,1H3,(H,26,27)/t18-,21-/m0/s1
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n/an/a 7.21n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486560
PNG
(34 | US10947251, Example 33)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@H]2COC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H22F4N4O6S/c1-36-21-10-17(14-3-2-4-16(9-14)24(26,27)28)18(25)11-20(21)32-19-5-7-31(12-15(19)13-37-23(32)33)39(34,35)30-22-6-8-38-29-22/h2-4,6,8-11,15,19H,5,7,12-13H2,1H3,(H,29,30)/t15-,19+/m0/s1
PDB

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n/an/a 10.4n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486549
PNG
(US10947251, Example 26)
Show SMILES COc1cc(c(F)cc1N1CCO[C@H]2CN(CC[C@H]12)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H24F4N4O5S/c1-35-21-12-17(15-3-2-4-16(11-15)24(26,27)28)18(25)13-20(21)32-8-10-36-22-14-31(7-5-19(22)32)38(33,34)30-23-6-9-37-29-23/h2-4,6,9,11-13,19,22H,5,7-8,10,14H2,1H3,(H,29,30)/t19-,22-/m0/s1
PDB

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n/an/a 10.6n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486566
PNG
(US10947251, Example 38)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@H]2CCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H24F4N4O5S/c1-37-22-12-18(15-3-2-4-17(11-15)25(27,28)29)19(26)13-21(22)33-20-7-9-32(14-16(20)5-6-24(33)34)39(35,36)31-23-8-10-38-30-23/h2-4,8,10-13,16,20H,5-7,9,14H2,1H3,(H,30,31)/t16-,20+/m1/s1
PDB

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n/an/a 10.7n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486559
PNG
(US10947251, Example 32)
Show SMILES COc1cc(c(F)cc1N1CCO[C@H]2CN(CC[C@H]12)S(=O)(=O)Nc1ccon1)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H24F4N4O6S/c1-35-21-12-17(15-3-2-4-16(11-15)38-24(26,27)28)18(25)13-20(21)32-8-10-36-22-14-31(7-5-19(22)32)39(33,34)30-23-6-9-37-29-23/h2-4,6,9,11-13,19,22H,5,7-8,10,14H2,1H3,(H,29,30)/t19-,22-/m0/s1
PDB

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n/an/a 10.9n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486534
PNG
(12 | US10947251, Example 11)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C24H21F5N4O6S/c1-37-19-9-14(13-3-2-4-15(23(13)26)24(27,28)29)16(25)10-18(19)33-17-5-7-32(11-20(17)38-12-22(33)34)40(35,36)31-21-6-8-39-30-21/h2-4,6,8-10,17,20H,5,7,11-12H2,1H3,(H,30,31)/t17-,20-/m1/s1
PDB

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n/an/a 11.2n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486536
PNG
(14 | US10947251, Example 13)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(Cl)c1
Show InChI InChI=1S/C23H22ClFN4O6S/c1-33-20-10-16(14-3-2-4-15(24)9-14)17(25)11-19(20)29-18-5-7-28(12-21(18)34-13-23(29)30)36(31,32)27-22-6-8-35-26-22/h2-4,6,8-11,18,21H,5,7,12-13H2,1H3,(H,26,27)/t18-,21-/m1/s1
PDB

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n/an/a 11.7n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486565
PNG
(US10947251, Example 37)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2CCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H24F4N4O5S/c1-37-22-12-18(15-3-2-4-17(11-15)25(27,28)29)19(26)13-21(22)33-20-7-9-32(14-16(20)5-6-24(33)34)39(35,36)31-23-8-10-38-30-23/h2-4,8,10-13,16,20H,5-7,9,14H2,1H3,(H,30,31)/t16-,20-/m0/s1
PDB

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n/an/a 12.9n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486527
PNG
(10 | US10947251, Example 9)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(F)c1
Show InChI InChI=1S/C23H22F2N4O6S/c1-33-20-10-16(14-3-2-4-15(24)9-14)17(25)11-19(20)29-18-5-7-28(12-21(18)34-13-23(29)30)36(31,32)27-22-6-8-35-26-22/h2-4,6,8-11,18,21H,5,7,12-13H2,1H3,(H,26,27)/t18-,21-/m1/s1
PDB

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n/an/a 19.4n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486564
PNG
(US10947251, Example 36)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@@H]2CCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H24F4N4O5S/c1-37-22-12-18(15-3-2-4-17(11-15)25(27,28)29)19(26)13-21(22)33-20-7-9-32(14-16(20)5-6-24(33)34)39(35,36)31-23-8-10-38-30-23/h2-4,8,10-13,16,20H,5-7,9,14H2,1H3,(H,30,31)/t16-,20+/m0/s1
PDB

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n/an/a 20.7n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486550
PNG
(28 | US10947251, Example 27)
Show SMILES COc1cc(c(F)cc1N1CCO[C@@H]2CN(CC[C@@H]12)S(=O)(=O)Nc1ccncn1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H25F4N5O4S/c1-37-22-12-18(16-3-2-4-17(11-16)25(27,28)29)19(26)13-21(22)34-9-10-38-23-14-33(8-6-20(23)34)39(35,36)32-24-5-7-30-15-31-24/h2-5,7,11-13,15,20,23H,6,8-10,14H2,1H3,(H,30,31,32)/t20-,23-/m1/s1
PDB

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n/an/a 21.2n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486551
PNG
(US10947251, Example 28)
Show SMILES COc1cc(c(F)cc1N1CCO[C@H]2CN(CC[C@H]12)S(=O)(=O)Nc1ccncn1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H25F4N5O4S/c1-37-22-12-18(16-3-2-4-17(11-16)25(27,28)29)19(26)13-21(22)34-9-10-38-23-14-33(8-6-20(23)34)39(35,36)32-24-5-7-30-15-31-24/h2-5,7,11-13,15,20,23H,6,8-10,14H2,1H3,(H,30,31,32)/t20-,23-/m0/s1
PDB

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n/an/a 26.3n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486557
PNG
(US10947251, Example 30)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H22F4N4O7S/c1-36-20-10-16(14-3-2-4-15(9-14)39-24(26,27)28)17(25)11-19(20)32-18-5-7-31(12-21(18)37-13-23(32)33)40(34,35)30-22-6-8-38-29-22/h2-4,6,8-11,18,21H,5,7,12-13H2,1H3,(H,29,30)/t18-,21-/m0/s1
PDB

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n/an/a 35.6n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486520
PNG
(US10947251, Example 2)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H21F5N4O6S/c1-37-20-9-14(13-2-3-16(25)15(8-13)24(27,28)29)17(26)10-19(20)33-18-4-6-32(11-21(18)38-12-23(33)34)40(35,36)31-22-5-7-39-30-22/h2-3,5,7-10,18,21H,4,6,11-12H2,1H3,(H,30,31)/t18-,21-/m0/s1
PDB

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n/an/a 38.4n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486543
PNG
(US10947251, Example 20)
Show SMILES COc1cc(cc(F)c1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H22F4N4O6S/c1-36-19-11-15(14-3-2-4-16(9-14)24(26,27)28)10-17(25)23(19)32-18-5-7-31(12-20(18)37-13-22(32)33)39(34,35)30-21-6-8-38-29-21/h2-4,6,8-11,18,20H,5,7,12-13H2,1H3,(H,29,30)/t18-,20-/m0/s1
PDB

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n/an/a 39.8n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486519
PNG
(2 | US10947251, Example 1)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H21F5N4O6S/c1-37-20-9-14(13-2-3-16(25)15(8-13)24(27,28)29)17(26)10-19(20)33-18-4-6-32(11-21(18)38-12-23(33)34)40(35,36)31-22-5-7-39-30-22/h2-3,5,7-10,18,21H,4,6,11-12H2,1H3,(H,30,31)/t18-,21-/m1/s1
PDB

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n/an/a 44.3n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486538
PNG
(16 | US10947251, Example 15)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)F
Show InChI InChI=1S/C24H23F3N4O6S/c1-35-20-10-16(14-3-2-4-15(9-14)24(26)27)17(25)11-19(20)31-18-5-7-30(12-21(18)36-13-23(31)32)38(33,34)29-22-6-8-37-28-22/h2-4,6,8-11,18,21,24H,5,7,12-13H2,1H3,(H,28,29)/t18-,21-/m1/s1
PDB

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n/an/a 46.7n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486544
PNG
(22 | US10947251, Example 21)
Show SMILES COc1nc(c(F)cc1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H21F4N5O6S/c1-36-22-17(10-15(24)21(28-22)13-3-2-4-14(9-13)23(25,26)27)32-16-5-7-31(11-18(16)37-12-20(32)33)39(34,35)30-19-6-8-38-29-19/h2-4,6,8-10,16,18H,5,7,11-12H2,1H3,(H,29,30)/t16-,18-/m1/s1
PDB

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n/an/a 47.5n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486529
PNG
(US10947251, Example 10)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(F)c1
Show InChI InChI=1S/C23H22F2N4O6S/c1-33-20-10-16(14-3-2-4-15(24)9-14)17(25)11-19(20)29-18-5-7-28(12-21(18)34-13-23(29)30)36(31,32)27-22-6-8-35-26-22/h2-4,6,8-11,18,21H,5,7,12-13H2,1H3,(H,26,27)/t18-,21-/m0/s1
PDB

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n/an/a 47.8n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486563
PNG
(US10947251, Example 35)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@H]2CCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H24F4N4O5S/c1-37-22-12-18(15-3-2-4-17(11-15)25(27,28)29)19(26)13-21(22)33-20-7-9-32(14-16(20)5-6-24(33)34)39(35,36)31-23-8-10-38-30-23/h2-4,8,10-13,16,20H,5-7,9,14H2,1H3,(H,30,31)/t16-,20-/m1/s1
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n/an/a 49.3n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486539
PNG
(US10947251, Example 16)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)F
Show InChI InChI=1S/C24H23F3N4O6S/c1-35-20-10-16(14-3-2-4-15(9-14)24(26)27)17(25)11-19(20)31-18-5-7-30(12-21(18)36-13-23(31)32)38(33,34)29-22-6-8-37-28-22/h2-4,6,8-11,18,21,24H,5,7,12-13H2,1H3,(H,28,29)/t18-,21-/m0/s1
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n/an/a 49.5n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486542
PNG
(20 | US10947251, Example 19)
Show SMILES COc1cc(cc(F)c1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H22F4N4O6S/c1-36-19-11-15(14-3-2-4-16(9-14)24(26,27)28)10-17(25)23(19)32-18-5-7-31(12-20(18)37-13-22(32)33)39(34,35)30-21-6-8-38-29-21/h2-4,6,8-11,18,20H,5,7,12-13H2,1H3,(H,29,30)/t18-,20-/m1/s1
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n/an/a 50n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486546
PNG
(24 | US10947251, Example 23)
Show SMILES Fc1cc(N2[C@@H]3CCN(C[C@H]3OCC2=O)S(=O)(=O)Nc2ccon2)c(cc1-c1cccc(c1)C(F)(F)F)C#N
Show InChI InChI=1S/C24H19F4N5O5S/c25-18-10-20(15(11-29)9-17(18)14-2-1-3-16(8-14)24(26,27)28)33-19-4-6-32(12-21(19)37-13-23(33)34)39(35,36)31-22-5-7-38-30-22/h1-3,5,7-10,19,21H,4,6,12-13H2,(H,30,31)/t19-,21-/m1/s1
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n/an/a 50.1n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486524
PNG
(US10947251, Example 6)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C24H21F5N4O6S/c1-37-20-9-16(13-6-14(24(27,28)29)8-15(25)7-13)17(26)10-19(20)33-18-2-4-32(11-21(18)38-12-23(33)34)40(35,36)31-22-3-5-39-30-22/h3,5-10,18,21H,2,4,11-12H2,1H3,(H,30,31)/t18-,21-/m0/s1
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n/an/a 52.9n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486522
PNG
(US10947251, Example 4)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H22F4N4O6S/c1-36-20-10-16(14-3-2-4-15(9-14)24(26,27)28)17(25)11-19(20)32-18-5-7-31(12-21(18)37-13-23(32)33)39(34,35)30-22-6-8-38-29-22/h2-4,6,8-11,18,21H,5,7,12-13H2,1H3,(H,29,30)/t18-,21-/m0/s1
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n/an/a 60n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486556
PNG
(30 | US10947251, Example 29)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H22F4N4O7S/c1-36-20-10-16(14-3-2-4-15(9-14)39-24(26,27)28)17(25)11-19(20)32-18-5-7-31(12-21(18)37-13-23(32)33)40(34,35)30-22-6-8-38-29-22/h2-4,6,8-11,18,21H,5,7,12-13H2,1H3,(H,29,30)/t18-,21-/m1/s1
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n/an/a 62.3n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486549
PNG
(US10947251, Example 26)
Show SMILES COc1cc(c(F)cc1N1CCO[C@H]2CN(CC[C@H]12)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H24F4N4O5S/c1-35-21-12-17(15-3-2-4-16(11-15)24(26,27)28)18(25)13-20(21)32-8-10-36-22-14-31(7-5-19(22)32)38(33,34)30-23-6-9-37-29-23/h2-4,6,9,11-13,19,22H,5,7-8,10,14H2,1H3,(H,29,30)/t19-,22-/m0/s1
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n/an/a 63.6n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486545
PNG
(US10947251, Example 22)
Show SMILES COc1nc(c(F)cc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H21F4N5O6S/c1-36-22-17(10-15(24)21(28-22)13-3-2-4-14(9-13)23(25,26)27)32-16-5-7-31(11-18(16)37-12-20(32)33)39(34,35)30-19-6-8-38-29-19/h2-4,6,8-10,16,18H,5,7,11-12H2,1H3,(H,29,30)/t16-,18-/m0/s1
PDB

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n/an/a 66.8n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486521
PNG
(4 | US10947251, Example 3)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H22F4N4O6S/c1-36-20-10-16(14-3-2-4-15(9-14)24(26,27)28)17(25)11-19(20)32-18-5-7-31(12-21(18)37-13-23(32)33)39(34,35)30-22-6-8-38-29-22/h2-4,6,8-11,18,21H,5,7,12-13H2,1H3,(H,29,30)/t18-,21-/m1/s1
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n/an/a 67n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486523
PNG
(6 | US10947251, Example 5)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C24H21F5N4O6S/c1-37-20-9-16(13-6-14(24(27,28)29)8-15(25)7-13)17(26)10-19(20)33-18-2-4-32(11-21(18)38-12-23(33)34)40(35,36)31-22-3-5-39-30-22/h3,5-10,18,21H,2,4,11-12H2,1H3,(H,30,31)/t18-,21-/m1/s1
PDB

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n/an/a 79n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486526
PNG
(US10947251, Example 8)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cc(ccc1F)C(F)(F)F
Show InChI InChI=1S/C24H21F5N4O6S/c1-37-20-9-15(14-8-13(24(27,28)29)2-3-16(14)25)17(26)10-19(20)33-18-4-6-32(11-21(18)38-12-23(33)34)40(35,36)31-22-5-7-39-30-22/h2-3,5,7-10,18,21H,4,6,11-12H2,1H3,(H,30,31)/t18-,21-/m0/s1
PDB

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n/an/a 82.8n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486560
PNG
(34 | US10947251, Example 33)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@H]2COC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H22F4N4O6S/c1-36-21-10-17(14-3-2-4-16(9-14)24(26,27)28)18(25)11-20(21)32-19-5-7-31(12-15(19)13-37-23(32)33)39(34,35)30-22-6-8-38-29-22/h2-4,6,8-11,15,19H,5,7,12-13H2,1H3,(H,29,30)/t15-,19+/m0/s1
PDB

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n/an/a 112n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486558
PNG
(32 | US10947251, Example 31)
Show SMILES COc1cc(c(F)cc1N1CCO[C@@H]2CN(CC[C@@H]12)S(=O)(=O)Nc1ccon1)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H24F4N4O6S/c1-35-21-12-17(15-3-2-4-16(11-15)38-24(26,27)28)18(25)13-20(21)32-8-10-36-22-14-31(7-5-19(22)32)39(33,34)30-23-6-9-37-29-23/h2-4,6,9,11-13,19,22H,5,7-8,10,14H2,1H3,(H,29,30)/t19-,22-/m1/s1
PDB

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n/an/a 128n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486535
PNG
(US10947251, Example 12)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C24H21F5N4O6S/c1-37-19-9-14(13-3-2-4-15(23(13)26)24(27,28)29)16(25)10-18(19)33-17-5-7-32(11-20(17)38-12-22(33)34)40(35,36)31-21-6-8-39-30-21/h2-4,6,8-10,17,20H,5,7,11-12H2,1H3,(H,30,31)/t17-,20-/m0/s1
PDB

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n/an/a 131n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486559
PNG
(US10947251, Example 32)
Show SMILES COc1cc(c(F)cc1N1CCO[C@H]2CN(CC[C@H]12)S(=O)(=O)Nc1ccon1)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H24F4N4O6S/c1-35-21-12-17(15-3-2-4-16(11-15)38-24(26,27)28)18(25)13-20(21)32-8-10-36-22-14-31(7-5-19(22)32)39(33,34)30-23-6-9-37-29-23/h2-4,6,9,11-13,19,22H,5,7-8,10,14H2,1H3,(H,29,30)/t19-,22-/m0/s1
PDB

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n/an/a 148n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486525
PNG
(8 | US10947251, Example 7)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cc(ccc1F)C(F)(F)F
Show InChI InChI=1S/C24H21F5N4O6S/c1-37-20-9-15(14-8-13(24(27,28)29)2-3-16(14)25)17(26)10-19(20)33-18-4-6-32(11-21(18)38-12-23(33)34)40(35,36)31-22-5-7-39-30-22/h2-3,5,7-10,18,21H,4,6,11-12H2,1H3,(H,30,31)/t18-,21-/m1/s1
PDB

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n/an/a 167n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486561
PNG
(US10947251, Example 34)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2COC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H22F4N4O6S/c1-36-21-10-17(14-3-2-4-16(9-14)24(26,27)28)18(25)11-20(21)32-19-5-7-31(12-15(19)13-37-23(32)33)39(34,35)30-22-6-8-38-29-22/h2-4,6,8-11,15,19H,5,7,12-13H2,1H3,(H,29,30)/t15-,19+/m1/s1
PDB

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n/an/a 196n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486548
PNG
(26 | US10947251, Example 25)
Show SMILES COc1cc(c(F)cc1N1CCO[C@@H]2CN(CC[C@@H]12)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H24F4N4O5S/c1-35-21-12-17(15-3-2-4-16(11-15)24(26,27)28)18(25)13-20(21)32-8-10-36-22-14-31(7-5-19(22)32)38(33,34)30-23-6-9-37-29-23/h2-4,6,9,11-13,19,22H,5,7-8,10,14H2,1H3,(H,29,30)/t19-,22-/m1/s1
PDB

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n/an/a 208n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486540
PNG
(18 | US10947251, Example 17)
Show SMILES COc1cc(ccc1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H23F3N4O6S/c1-35-20-12-16(15-3-2-4-17(11-15)24(25,26)27)5-6-18(20)31-19-7-9-30(13-21(19)36-14-23(31)32)38(33,34)29-22-8-10-37-28-22/h2-6,8,10-12,19,21H,7,9,13-14H2,1H3,(H,28,29)/t19-,21-/m1/s1
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n/an/a 214n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486534
PNG
(12 | US10947251, Example 11)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C24H21F5N4O6S/c1-37-19-9-14(13-3-2-4-15(23(13)26)24(27,28)29)16(25)10-18(19)33-17-5-7-32(11-20(17)38-12-22(33)34)40(35,36)31-21-6-8-39-30-21/h2-4,6,8-10,17,20H,5,7,11-12H2,1H3,(H,30,31)/t17-,20-/m1/s1
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n/an/a 230n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486547
PNG
(US10947251, Example 24)
Show SMILES Fc1cc(N2[C@H]3CCN(C[C@@H]3OCC2=O)S(=O)(=O)Nc2ccon2)c(cc1-c1cccc(c1)C(F)(F)F)C#N
Show InChI InChI=1S/C24H19F4N5O5S/c25-18-10-20(15(11-29)9-17(18)14-2-1-3-16(8-14)24(26,27)28)33-19-4-6-32(12-21(19)37-13-23(33)34)39(35,36)31-22-5-7-38-30-22/h1-3,5,7-10,19,21H,4,6,12-13H2,(H,30,31)/t19-,21-/m0/s1
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n/an/a 237n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486537
PNG
(US10947251, Example 14)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(Cl)c1
Show InChI InChI=1S/C23H22ClFN4O6S/c1-33-20-10-16(14-3-2-4-15(24)9-14)17(25)11-19(20)29-18-5-7-28(12-21(18)34-13-23(29)30)36(31,32)27-22-6-8-35-26-22/h2-4,6,8-11,18,21H,5,7,12-13H2,1H3,(H,26,27)/t18-,21-/m0/s1
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n/an/a 332n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486541
PNG
(US10947251, Example 18)
Show SMILES COc1cc(ccc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H23F3N4O6S/c1-35-20-12-16(15-3-2-4-17(11-15)24(25,26)27)5-6-18(20)31-19-7-9-30(13-21(19)36-14-23(31)32)38(33,34)29-22-8-10-37-28-22/h2-6,8,10-12,19,21H,7,9,13-14H2,1H3,(H,28,29)/t19-,21-/m0/s1
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n/an/a 346n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486536
PNG
(14 | US10947251, Example 13)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(Cl)c1
Show InChI InChI=1S/C23H22ClFN4O6S/c1-33-20-10-16(14-3-2-4-15(24)9-14)17(25)11-19(20)29-18-5-7-28(12-21(18)34-13-23(29)30)36(31,32)27-22-6-8-35-26-22/h2-4,6,8-11,18,21H,5,7,12-13H2,1H3,(H,26,27)/t18-,21-/m1/s1
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n/an/a 471n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486566
PNG
(US10947251, Example 38)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@H]2CCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H24F4N4O5S/c1-37-22-12-18(15-3-2-4-17(11-15)25(27,28)29)19(26)13-21(22)33-20-7-9-32(14-16(20)5-6-24(33)34)39(35,36)31-23-8-10-38-30-23/h2-4,8,10-13,16,20H,5-7,9,14H2,1H3,(H,30,31)/t16-,20+/m1/s1
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n/an/a 641n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486529
PNG
(US10947251, Example 10)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(F)c1
Show InChI InChI=1S/C23H22F2N4O6S/c1-33-20-10-16(14-3-2-4-15(24)9-14)17(25)11-19(20)29-18-5-7-28(12-21(18)34-13-23(29)30)36(31,32)27-22-6-8-35-26-22/h2-4,6,8-11,18,21H,5,7,12-13H2,1H3,(H,26,27)/t18-,21-/m0/s1
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n/an/a 716n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486565
PNG
(US10947251, Example 37)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2CCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H24F4N4O5S/c1-37-22-12-18(15-3-2-4-17(11-15)25(27,28)29)19(26)13-21(22)33-20-7-9-32(14-16(20)5-6-24(33)34)39(35,36)31-23-8-10-38-30-23/h2-4,8,10-13,16,20H,5-7,9,14H2,1H3,(H,30,31)/t16-,20-/m0/s1
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n/an/a 761n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486542
PNG
(20 | US10947251, Example 19)
Show SMILES COc1cc(cc(F)c1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H22F4N4O6S/c1-36-19-11-15(14-3-2-4-16(9-14)24(26,27)28)10-17(25)23(19)32-18-5-7-31(12-20(18)37-13-22(32)33)39(34,35)30-21-6-8-38-29-21/h2-4,6,8-11,18,20H,5,7,12-13H2,1H3,(H,29,30)/t18-,20-/m1/s1
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n/an/a 831n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486545
PNG
(US10947251, Example 22)
Show SMILES COc1nc(c(F)cc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H21F4N5O6S/c1-36-22-17(10-15(24)21(28-22)13-3-2-4-14(9-13)23(25,26)27)32-16-5-7-31(11-18(16)37-12-20(32)33)39(34,35)30-19-6-8-38-29-19/h2-4,6,8-10,16,18H,5,7,11-12H2,1H3,(H,29,30)/t16-,18-/m0/s1
PDB

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n/an/a 907n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486539
PNG
(US10947251, Example 16)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)F
Show InChI InChI=1S/C24H23F3N4O6S/c1-35-20-10-16(14-3-2-4-15(9-14)24(26)27)17(25)11-19(20)31-18-5-7-30(12-21(18)36-13-23(31)32)38(33,34)29-22-6-8-37-28-22/h2-4,6,8-11,18,21,24H,5,7,12-13H2,1H3,(H,28,29)/t18-,21-/m0/s1
PDB

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n/an/a 1.39E+3n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486547
PNG
(US10947251, Example 24)
Show SMILES Fc1cc(N2[C@H]3CCN(C[C@@H]3OCC2=O)S(=O)(=O)Nc2ccon2)c(cc1-c1cccc(c1)C(F)(F)F)C#N
Show InChI InChI=1S/C24H19F4N5O5S/c25-18-10-20(15(11-29)9-17(18)14-2-1-3-16(8-14)24(26,27)28)33-19-4-6-32(12-21(19)37-13-23(33)34)39(35,36)31-22-5-7-38-30-22/h1-3,5,7-10,19,21H,4,6,12-13H2,(H,30,31)/t19-,21-/m0/s1
PDB

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n/an/a 2.00E+3n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486538
PNG
(16 | US10947251, Example 15)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)F
Show InChI InChI=1S/C24H23F3N4O6S/c1-35-20-10-16(14-3-2-4-15(9-14)24(26)27)17(25)11-19(20)31-18-5-7-30(12-21(18)36-13-23(31)32)38(33,34)29-22-6-8-37-28-22/h2-4,6,8-11,18,21,24H,5,7,12-13H2,1H3,(H,28,29)/t18-,21-/m1/s1
PDB

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n/an/a 2.00E+3n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486543
PNG
(US10947251, Example 20)
Show SMILES COc1cc(cc(F)c1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H22F4N4O6S/c1-36-19-11-15(14-3-2-4-16(9-14)24(26,27)28)10-17(25)23(19)32-18-5-7-31(12-20(18)37-13-22(32)33)39(34,35)30-21-6-8-38-29-21/h2-4,6,8-11,18,20H,5,7,12-13H2,1H3,(H,29,30)/t18-,20-/m0/s1
PDB

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n/an/a 2.00E+3n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486527
PNG
(10 | US10947251, Example 9)
Show SMILES COc1cc(c(F)cc1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(F)c1
Show InChI InChI=1S/C23H22F2N4O6S/c1-33-20-10-16(14-3-2-4-15(24)9-14)17(25)11-19(20)29-18-5-7-28(12-21(18)34-13-23(29)30)36(31,32)27-22-6-8-35-26-22/h2-4,6,8-11,18,21H,5,7,12-13H2,1H3,(H,26,27)/t18-,21-/m1/s1
PDB

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n/an/a 2.00E+3n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486546
PNG
(24 | US10947251, Example 23)
Show SMILES Fc1cc(N2[C@@H]3CCN(C[C@H]3OCC2=O)S(=O)(=O)Nc2ccon2)c(cc1-c1cccc(c1)C(F)(F)F)C#N
Show InChI InChI=1S/C24H19F4N5O5S/c25-18-10-20(15(11-29)9-17(18)14-2-1-3-16(8-14)24(26,27)28)33-19-4-6-32(12-21(19)37-13-23(33)34)39(35,36)31-22-5-7-38-30-22/h1-3,5,7-10,19,21H,4,6,12-13H2,(H,30,31)/t19-,21-/m1/s1
PDB

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n/an/a 2.00E+3n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486544
PNG
(22 | US10947251, Example 21)
Show SMILES COc1nc(c(F)cc1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H21F4N5O6S/c1-36-22-17(10-15(24)21(28-22)13-3-2-4-14(9-13)23(25,26)27)32-16-5-7-31(11-18(16)37-12-20(32)33)39(34,35)30-19-6-8-38-29-19/h2-4,6,8-10,16,18H,5,7,11-12H2,1H3,(H,29,30)/t16-,18-/m1/s1
PDB

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n/an/a 2.00E+3n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM486561
PNG
(US10947251, Example 34)
Show SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2COC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H22F4N4O6S/c1-36-21-10-17(14-3-2-4-16(9-14)24(26,27)28)18(25)11-20(21)32-19-5-7-31(12-15(19)13-37-23(32)33)39(34,35)30-22-6-8-38-29-22/h2-4,6,8-11,15,19H,5,7,12-13H2,1H3,(H,29,30)/t15-,19+/m1/s1
PDB

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n/an/a 2.00E+3n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...


US Patent US10947251 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%