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Patent code US10954241

Compile Data Set for Download or QSAR

Found 320 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488431
PNG
(1-(2-(4-Amino-1-(tert-butyl)-1H-pyrazolo[3,4- d]py...)
Show SMILES CNC(=O)Nc1ccc2cc([nH]c2c1)-c1nn(c2ncnc(N)c12)C(C)(C)C
Show InChI InChI=1S/C19H22N8O/c1-19(2,3)27-17-14(16(20)22-9-23-17)15(26-27)13-7-10-5-6-11(8-12(10)25-13)24-18(28)21-4/h5-9,25H,1-4H3,(H2,20,22,23)(H2,21,24,28)
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n/an/a 1.02n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488414
PNG
(N-(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)
Show SMILES CC(=O)Nc1ccc2cc([nH]c2c1)-c1nn(c2ncnc(N)c12)C(C)(C)C
Show InChI InChI=1S/C19H21N7O/c1-10(27)23-12-6-5-11-7-14(24-13(11)8-12)16-15-17(20)21-9-22-18(15)26(25-16)19(2,3)4/h5-9,24H,1-4H3,(H,23,27)(H2,20,21,22)
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n/an/a 2.20n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488365
PNG
(2-(4-Amino-1-isopropyl-pyrazolo[3,4-d]pyrimidin- 3...)
Show SMILES CNC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1nn(C(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C18H18ClN7O/c1-8(2)26-17-12(16(20)22-7-23-17)14(25-26)15-13(19)10-5-4-9(18(27)21-3)6-11(10)24-15/h4-8,24H,1-3H3,(H,21,27)(H2,20,22,23)
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n/an/a 3.15n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488467
PNG
(3-[3-Chloro-6-(1,3,4-thiadiazol-2-yl)-1H-indol-2- ...)
Show SMILES CC(C)n1nc(-c2[nH]c3cc(ccc3c2Cl)-c2nncs2)c2c(N)ncnc12
Show InChI InChI=1S/C18H15ClN8S/c1-8(2)27-17-12(16(20)21-6-22-17)14(26-27)15-13(19)10-4-3-9(5-11(10)24-15)18-25-23-7-28-18/h3-8,24H,1-2H3,(H2,20,21,22)
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n/an/a 4.15n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488468
PNG
(1-Isopropyl-3-(6-oxazol-2-yl-1H-indol-2- yl)pyrazo...)
Show SMILES CC(C)n1nc(-c2cc3ccc(cc3[nH]2)-c2ncco2)c2c(N)ncnc12
Show InChI InChI=1S/C19H17N7O/c1-10(2)26-18-15(17(20)22-9-23-18)16(25-26)14-7-11-3-4-12(8-13(11)24-14)19-21-5-6-27-19/h3-10,24H,1-2H3,(H2,20,22,23)
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n/an/a 4.19n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488464
PNG
(2-[4-Amino-1-(3-hydroxycyclopentyl)-1H- pyrazolo[3...)
Show SMILES Nc1ncnc2n(nc(-c3[nH]c4cc(ccc4c3Cl)C(=O)NC3CC3)c12)C1CCC(O)C1
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n/an/a 4.25n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488369
PNG
(2-(8-Amino-3-isopropylimidazo[1,5-a]pyrazin-1- yl)...)
Show SMILES CNC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1nc(C(C)C)n2ccnc(N)c12
Show InChI InChI=1S/C19H19ClN6O/c1-9(2)18-25-15(16-17(21)23-6-7-26(16)18)14-13(20)11-5-4-10(19(27)22-3)8-12(11)24-14/h4-9,24H,1-3H3,(H2,21,23)(H,22,27)
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n/an/a 4.53n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488366
PNG
(2-(4-Amino-7-isopropyl-7H-pyrrolo[2,3- d]pyrimidin...)
Show SMILES CNC(=O)c1ccc2cc([nH]c2c1)-c1cn(C(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C19H20N6O/c1-10(2)25-8-13(16-17(20)22-9-23-18(16)25)15-6-11-4-5-12(19(26)21-3)7-14(11)24-15/h4-10,24H,1-3H3,(H,21,26)(H2,20,22,23)
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n/an/a 4.57n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488449
PNG
(2-[4-Amino-1-(1-methanesulfonylpiperidin-4-yl)- 1H...)
Show SMILES CS(=O)(=O)N1CCC(CC1)n1nc(-c2[nH]c3cc(ccc3c2Cl)C(=O)NC2CC2)c2c(N)ncnc12
Show InChI InChI=1S/C23H25ClN8O3S/c1-36(34,35)31-8-6-14(7-9-31)32-22-17(21(25)26-11-27-22)19(30-32)20-18(24)15-5-2-12(10-16(15)29-20)23(33)28-13-3-4-13/h2,5,10-11,13-14,29H,3-4,6-9H2,1H3,(H,28,33)(H2,25,26,27)
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n/an/a 4.73n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488407
PNG
(2-[4-Amino-7-(propan-2-yl)pyrrolo[2,1- f][1,2,4]tr...)
Show SMILES CNC(=O)c1ccc2cc([nH]c2c1)-c1cc(C(C)C)n2ncnc(N)c12
Show InChI InChI=1S/C19H20N6O/c1-10(2)16-8-13(17-18(20)22-9-23-25(16)17)15-6-11-4-5-12(19(26)21-3)7-14(11)24-15/h4-10,24H,1-3H3,(H,21,26)(H2,20,22,23)
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n/an/a 4.84n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488446
PNG
(2-{4-Amino-1-cyclopentyl-1H-pyrazolo[3,4- d]pyrimi...)
Show SMILES CNC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1nn(C2CCCC2)c2ncnc(N)c12
Show InChI InChI=1S/C20H20ClN7O/c1-23-20(29)10-6-7-12-13(8-10)26-17(15(12)21)16-14-18(22)24-9-25-19(14)28(27-16)11-4-2-3-5-11/h6-9,11,26H,2-5H2,1H3,(H,23,29)(H2,22,24,25)
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n/an/a 5.23n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488398
PNG
(2-[4-Amino-1-(propan-2-yl)-1H-pyrazolo[4,3- c]pyri...)
Show SMILES CNC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1nn(C(C)C)c2ccnc(N)c12
Show InChI InChI=1S/C19H19ClN6O/c1-9(2)26-13-6-7-23-18(21)14(13)16(25-26)17-15(20)11-5-4-10(19(27)22-3)8-12(11)24-17/h4-9,24H,1-3H3,(H2,21,23)(H,22,27)
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n/an/a 5.24n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488409
PNG
(2-[4-Amino-7-(propan-2-yl)imidazo[4,3- f][1,2,4]tr...)
Show SMILES CNC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1nc(C(C)C)n2ncnc(N)c12
Show InChI InChI=1S/C18H18ClN7O/c1-8(2)17-25-14(15-16(20)22-7-23-26(15)17)13-12(19)10-5-4-9(18(27)21-3)6-11(10)24-13/h4-8,24H,1-3H3,(H,21,27)(H2,20,22,23)
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n/an/a 5.41n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM488400
PNG
(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Show SMILES CN(C)CCn1ccc(NC(=O)c2ccc3c(Cl)c([nH]c3c2)-c2nn(c3ncnc(N)c23)C(C)(C)C)n1
Show InChI InChI=1S/C25H29ClN10O/c1-25(2,3)36-23-18(22(27)28-13-29-23)20(33-36)21-19(26)15-7-6-14(12-16(15)30-21)24(37)31-17-8-9-35(32-17)11-10-34(4)5/h6-9,12-13,30H,10-11H2,1-5H3,(H2,27,28,29)(H,31,32,37)
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n/an/a 5.55n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488403
PNG
(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Show SMILES CC(C)(C)n1nc(-c2[nH]c3cc(ccc3c2Cl)C(=O)Nc2ccn(CCO)n2)c2c(N)ncnc12
Show InChI InChI=1S/C23H24ClN9O2/c1-23(2,3)33-21-16(20(25)26-11-27-21)18(31-33)19-17(24)13-5-4-12(10-14(13)28-19)22(35)29-15-6-7-32(30-15)8-9-34/h4-7,10-11,28,34H,8-9H2,1-3H3,(H2,25,26,27)(H,29,30,35)
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n/an/a 5.66n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488389
PNG
(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Show SMILES CNC(=O)c1ccc2c(F)c([nH]c2c1)-c1nn(c2ncnc(N)c12)C(C)(C)C
Show InChI InChI=1S/C19H20FN7O/c1-19(2,3)27-17-12(16(21)23-8-24-17)14(26-27)15-13(20)10-6-5-9(18(28)22-4)7-11(10)25-15/h5-8,25H,1-4H3,(H,22,28)(H2,21,23,24)
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n/an/a 5.78n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488422
PNG
(2-{4-Amino-1-cyclobutyl-1H-pyrazolo[3,4- d]pyrimid...)
Show SMILES CNC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1nn(C2CCC2)c2ncnc(N)c12
Show InChI InChI=1S/C19H18ClN7O/c1-22-19(28)9-5-6-11-12(7-9)25-16(14(11)20)15-13-17(21)23-8-24-18(13)27(26-15)10-3-2-4-10/h5-8,10,25H,2-4H2,1H3,(H,22,28)(H2,21,23,24)
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n/an/a 5.78n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM488403
PNG
(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Show SMILES CC(C)(C)n1nc(-c2[nH]c3cc(ccc3c2Cl)C(=O)Nc2ccn(CCO)n2)c2c(N)ncnc12
Show InChI InChI=1S/C23H24ClN9O2/c1-23(2,3)33-21-16(20(25)26-11-27-21)18(31-33)19-17(24)13-5-4-12(10-14(13)28-19)22(35)29-15-6-7-32(30-15)8-9-34/h4-7,10-11,28,34H,8-9H2,1-3H3,(H2,25,26,27)(H,29,30,35)
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n/an/a 5.83n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488469
PNG
(3-(3-Chloro-6-oxazol-2-yl-1H-indol-2-yl)-1- isopro...)
Show SMILES CC(C)n1nc(-c2[nH]c3cc(ccc3c2Cl)-c2ncco2)c2c(N)ncnc12
Show InChI InChI=1S/C19H16ClN7O/c1-9(2)27-18-13(17(21)23-8-24-18)15(26-27)16-14(20)11-4-3-10(7-12(11)25-16)19-22-5-6-28-19/h3-9,25H,1-2H3,(H2,21,23,24)
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n/an/a 6.29n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488424
PNG
(2-{4-Amino-1-cyclopentyl-1H-pyrazolo[3,4- d]pyrimi...)
Show SMILES CNC(=O)c1ccc2cc([nH]c2c1)-c1nn(C2CCCC2)c2ncnc(N)c12
Show InChI InChI=1S/C20H21N7O/c1-22-20(28)12-7-6-11-8-15(25-14(11)9-12)17-16-18(21)23-10-24-19(16)27(26-17)13-4-2-3-5-13/h6-10,13,25H,2-5H2,1H3,(H,22,28)(H2,21,23,24)
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n/an/a 6.35n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488421
PNG
(2-[4-Amino-7-chloro-1-(propan-2-yl)-1H- pyrazolo[4...)
Show SMILES CNC(=O)c1ccc2cc([nH]c2c1)-c1nn(C(C)C)c2c(Cl)cnc(N)c12
Show InChI InChI=1S/C19H19ClN6O/c1-9(2)26-17-12(20)8-23-18(21)15(17)16(25-26)14-6-10-4-5-11(19(27)22-3)7-13(10)24-14/h4-9,24H,1-3H3,(H2,21,23)(H,22,27)
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n/an/a 7.15n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488400
PNG
(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Show SMILES CN(C)CCn1ccc(NC(=O)c2ccc3c(Cl)c([nH]c3c2)-c2nn(c3ncnc(N)c23)C(C)(C)C)n1
Show InChI InChI=1S/C25H29ClN10O/c1-25(2,3)36-23-18(22(27)28-13-29-23)20(33-36)21-19(26)15-7-6-14(12-16(15)30-21)24(37)31-17-8-9-35(32-17)11-10-34(4)5/h6-9,12-13,30H,10-11H2,1-5H3,(H2,27,28,29)(H,31,32,37)
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n/an/a 7.36n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM488378
PNG
(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Show SMILES CONC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1nn(c2ncnc(N)c12)C(C)(C)C
Show InChI InChI=1S/C19H20ClN7O2/c1-19(2,3)27-17-12(16(21)22-8-23-17)14(25-27)15-13(20)10-6-5-9(7-11(10)24-15)18(28)26-29-4/h5-8,24H,1-4H3,(H,26,28)(H2,21,22,23)
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n/an/a 7.66n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488392
PNG
(2-[4-Amino-1-(1-methylsulfonyl-4- piperidyl)pyrazo...)
Show SMILES CNC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1nn(C2CCN(CC2)S(C)(=O)=O)c2ncnc(N)c12
Show InChI InChI=1S/C21H23ClN8O3S/c1-24-21(31)11-3-4-13-14(9-11)27-18(16(13)22)17-15-19(23)25-10-26-20(15)30(28-17)12-5-7-29(8-6-12)34(2,32)33/h3-4,9-10,12,27H,5-8H2,1-2H3,(H,24,31)(H2,23,25,26)
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n/an/a 7.93n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488466
PNG
(1-Isopropyl-3-[6-(1,3,4-thiadiazol-2-yl)-1H-indol-...)
Show SMILES CC(C)n1nc(-c2cc3ccc(cc3[nH]2)-c2nncs2)c2c(N)ncnc12
Show InChI InChI=1S/C18H16N8S/c1-9(2)26-17-14(16(19)20-7-21-17)15(25-26)13-5-10-3-4-11(6-12(10)23-13)18-24-22-8-27-18/h3-9,23H,1-2H3,(H2,19,20,21)
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n/an/a 7.95n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488367
PNG
(2-(4-Amino-7-isopropyl-7H-pyrrolo[2,3- d]pyrimidin...)
Show SMILES CNC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1cn(C(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C19H19ClN6O/c1-9(2)26-7-12(14-17(21)23-8-24-18(14)26)16-15(20)11-5-4-10(19(27)22-3)6-13(11)25-16/h4-9,25H,1-3H3,(H,22,27)(H2,21,23,24)
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n/an/a 8.03n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488408
PNG
(2-[4-Amino-7-(propan-2-yl)pyrrolo[2,1- f][1,2,4]tr...)
Show SMILES CNC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1cc(C(C)C)n2ncnc(N)c12
Show InChI InChI=1S/C19H19ClN6O/c1-9(2)14-7-12(17-18(21)23-8-24-26(14)17)16-15(20)11-5-4-10(19(27)22-3)6-13(11)25-16/h4-9,25H,1-3H3,(H,22,27)(H2,21,23,24)
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n/an/a 8.31n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM488464
PNG
(2-[4-Amino-1-(3-hydroxycyclopentyl)-1H- pyrazolo[3...)
Show SMILES Nc1ncnc2n(nc(-c3[nH]c4cc(ccc4c3Cl)C(=O)NC3CC3)c12)C1CCC(O)C1
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n/an/a 8.48n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488463
PNG
(2-[4-Amino-1-(oxan-4-yl)-1H-pyrazolo[3,4- d]pyrimi...)
Show SMILES Nc1ncnc2n(nc(-c3[nH]c4cc(ccc4c3Cl)C(=O)NC3CC3)c12)C1CCOCC1
Show InChI InChI=1S/C22H22ClN7O2/c23-17-14-4-1-11(22(31)27-12-2-3-12)9-15(14)28-19(17)18-16-20(24)25-10-26-21(16)30(29-18)13-5-7-32-8-6-13/h1,4,9-10,12-13,28H,2-3,5-8H2,(H,27,31)(H2,24,25,26)
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n/an/a 8.66n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM488449
PNG
(2-[4-Amino-1-(1-methanesulfonylpiperidin-4-yl)- 1H...)
Show SMILES CS(=O)(=O)N1CCC(CC1)n1nc(-c2[nH]c3cc(ccc3c2Cl)C(=O)NC2CC2)c2c(N)ncnc12
Show InChI InChI=1S/C23H25ClN8O3S/c1-36(34,35)31-8-6-14(7-9-31)32-22-17(21(25)26-11-27-22)19(30-32)20-18(24)15-5-2-12(10-16(15)29-20)23(33)28-13-3-4-13/h2,5,10-11,13-14,29H,3-4,6-9H2,1H3,(H,28,33)(H2,25,26,27)
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n/an/a 8.72n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488378
PNG
(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Show SMILES CONC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1nn(c2ncnc(N)c12)C(C)(C)C
Show InChI InChI=1S/C19H20ClN7O2/c1-19(2,3)27-17-12(16(21)22-8-23-17)14(25-27)15-13(20)10-6-5-9(7-11(10)24-15)18(28)26-29-4/h5-8,24H,1-4H3,(H,26,28)(H2,21,22,23)
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n/an/a 8.73n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488448
PNG
(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyrimid...)
Show SMILES CC(C)(C)n1nc(-c2[nH]c3cc(ccc3c2Cl)C(=O)Nc2nccs2)c2c(N)ncnc12
Show InChI InChI=1S/C21H19ClN8OS/c1-21(2,3)30-18-13(17(23)25-9-26-18)15(29-30)16-14(22)11-5-4-10(8-12(11)27-16)19(31)28-20-24-6-7-32-20/h4-9,27H,1-3H3,(H2,23,25,26)(H,24,28,31)
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n/an/a 9.49n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488461
PNG
(2-[4-Amino-1-(oxolan-3-yl)-1H-pyrazolo[3,4- d]pyri...)
Show SMILES Nc1ncnc2n(nc(-c3[nH]c4cc(ccc4c3Cl)C(=O)NC3CC3)c12)C1CCOC1
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n/an/a 9.88n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488425
PNG
(2-(4-Amino-1-cyclohexyl-1H-pyrazolo[3,4- d]pyrimid...)
Show SMILES CNC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1nn(C2CCCCC2)c2ncnc(N)c12
Show InChI InChI=1S/C21H22ClN7O/c1-24-21(30)11-7-8-13-14(9-11)27-18(16(13)22)17-15-19(23)25-10-26-20(15)29(28-17)12-5-3-2-4-6-12/h7-10,12,27H,2-6H2,1H3,(H,24,30)(H2,23,25,26)
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n/an/a 10n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488417
PNG
(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyrimid...)
Show SMILES CCNC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1nn(c2ncnc(N)c12)C(C)(C)C
Show InChI InChI=1S/C20H22ClN7O/c1-5-23-19(29)10-6-7-11-12(8-10)26-16(14(11)21)15-13-17(22)24-9-25-18(13)28(27-15)20(2,3)4/h6-9,26H,5H2,1-4H3,(H,23,29)(H2,22,24,25)
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n/an/a 10.6n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488442
PNG
(N-(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)
Show SMILES CC(=O)Nc1ccc2c(Cl)c([nH]c2c1)-c1nn(c2ncnc(N)c12)C(C)(C)C
Show InChI InChI=1S/C19H20ClN7O/c1-9(28)24-10-5-6-11-12(7-10)25-16(14(11)20)15-13-17(21)22-8-23-18(13)27(26-15)19(2,3)4/h5-8,25H,1-4H3,(H,24,28)(H2,21,22,23)
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n/an/a 11.1n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488456
PNG
(2-[4-Amino-1-(oxan-4-ylmethyl)-1H-pyrazolo[3,4- d]...)
Show SMILES Nc1ncnc2n(CC3CCOCC3)nc(-c3[nH]c4cc(ccc4c3Cl)C(=O)NC3CC3)c12
Show InChI InChI=1S/C23H24ClN7O2/c24-18-15-4-1-13(23(32)28-14-2-3-14)9-16(15)29-20(18)19-17-21(25)26-11-27-22(17)31(30-19)10-12-5-7-33-8-6-12/h1,4,9,11-12,14,29H,2-3,5-8,10H2,(H,28,32)(H2,25,26,27)
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n/an/a 13n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM488367
PNG
(2-(4-Amino-7-isopropyl-7H-pyrrolo[2,3- d]pyrimidin...)
Show SMILES CNC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1cn(C(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C19H19ClN6O/c1-9(2)26-7-12(14-17(21)23-8-24-18(14)26)16-15(20)11-5-4-10(19(27)22-3)6-13(11)25-16/h4-9,25H,1-3H3,(H,22,27)(H2,21,23,24)
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n/an/a 13n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488373
PNG
(2-(8-Amino-3-isopropyl-imidazo[1,5-a]pyrazin-1- yl...)
Show SMILES CNC(=O)c1ccc2cc([nH]c2c1)-c1nc(C(C)C)n2ccnc(N)c12
Show InChI InChI=1S/C19H20N6O/c1-10(2)18-24-15(16-17(20)22-6-7-25(16)18)14-8-11-4-5-12(19(26)21-3)9-13(11)23-14/h4-10,23H,1-3H3,(H2,20,22)(H,21,26)
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n/an/a 13.2n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488454
PNG
(2-[4-Amino-1-(oxan-4-ylmethyl)-1H-pyrazolo[3,4- d]...)
Show SMILES CNC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1nn(CC2CCOCC2)c2ncnc(N)c12
Show InChI InChI=1S/C21H22ClN7O2/c1-24-21(30)12-2-3-13-14(8-12)27-18(16(13)22)17-15-19(23)25-10-26-20(15)29(28-17)9-11-4-6-31-7-5-11/h2-3,8,10-11,27H,4-7,9H2,1H3,(H,24,30)(H2,23,25,26)
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n/an/a 13.8n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488428
PNG
(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyrimid...)
Show SMILES CC(C)(C)n1nc(-c2[nH]c3cc(ccc3c2Cl)C(N)=O)c2c(N)ncnc12
Show InChI InChI=1S/C18H18ClN7O/c1-18(2,3)26-17-11(15(20)22-7-23-17)13(25-26)14-12(19)9-5-4-8(16(21)27)6-10(9)24-14/h4-7,24H,1-3H3,(H2,21,27)(H2,20,22,23)
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n/an/a 14.2n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488383
PNG
(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Show SMILES CC(C)(C)n1nc(-c2[nH]c3cc(ccc3c2Cl)C(=O)NCCO)c2c(N)ncnc12
Show InChI InChI=1S/C20H22ClN7O2/c1-20(2,3)28-18-13(17(22)24-9-25-18)15(27-28)16-14(21)11-5-4-10(8-12(11)26-16)19(30)23-6-7-29/h4-5,8-9,26,29H,6-7H2,1-3H3,(H,23,30)(H2,22,24,25)
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n/an/a 14.3n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488368
PNG
(2-(4-Amino-1-(tert-butyl)-1H-pyrazolo[3,4- d]pyrim...)
Show SMILES CNC(=O)c1ccc2c(Br)c([nH]c2c1)-c1nn(c2ncnc(N)c12)C(C)(C)C
Show InChI InChI=1S/C19H20BrN7O/c1-19(2,3)27-17-12(16(21)23-8-24-17)14(26-27)15-13(20)10-6-5-9(18(28)22-4)7-11(10)25-15/h5-8,25H,1-4H3,(H,22,28)(H2,21,23,24)
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n/an/a 14.7n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM488369
PNG
(2-(8-Amino-3-isopropylimidazo[1,5-a]pyrazin-1- yl)...)
Show SMILES CNC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1nc(C(C)C)n2ccnc(N)c12
Show InChI InChI=1S/C19H19ClN6O/c1-9(2)18-25-15(16-17(21)23-6-7-26(16)18)14-13(20)11-5-4-10(19(27)22-3)8-12(11)24-14/h4-9,24H,1-3H3,(H2,21,23)(H,22,27)
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n/an/a 14.8n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM488388
PNG
(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Show SMILES CC(C)OCCCNC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1nn(c2ncnc(N)c12)C(C)(C)C
Show InChI InChI=1S/C24H30ClN7O2/c1-13(2)34-10-6-9-27-23(33)14-7-8-15-16(11-14)30-20(18(15)25)19-17-21(26)28-12-29-22(17)32(31-19)24(3,4)5/h7-8,11-13,30H,6,9-10H2,1-5H3,(H,27,33)(H2,26,28,29)
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n/an/a 15.3n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM488409
PNG
(2-[4-Amino-7-(propan-2-yl)imidazo[4,3- f][1,2,4]tr...)
Show SMILES CNC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1nc(C(C)C)n2ncnc(N)c12
Show InChI InChI=1S/C18H18ClN7O/c1-8(2)17-25-14(15-16(20)22-7-23-26(15)17)13-12(19)10-5-4-9(18(27)21-3)6-11(10)24-13/h4-8,24H,1-3H3,(H,21,27)(H2,20,22,23)
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n/an/a 16.2n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM488365
PNG
(2-(4-Amino-1-isopropyl-pyrazolo[3,4-d]pyrimidin- 3...)
Show SMILES CNC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1nn(C(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C18H18ClN7O/c1-8(2)26-17-12(16(20)22-7-23-17)14(25-26)15-13(19)10-5-4-9(18(27)21-3)6-11(10)24-15/h4-8,24H,1-3H3,(H,21,27)(H2,20,22,23)
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n/an/a 16.5n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488429
PNG
(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyrimid...)
Show SMILES CNC(=O)c1cc2[nH]c(c(Cl)c2cc1Cl)-c1nn(c2ncnc(N)c12)C(C)(C)C
Show InChI InChI=1S/C19H19Cl2N7O/c1-19(2,3)28-17-12(16(22)24-7-25-17)14(27-28)15-13(21)9-5-10(20)8(18(29)23-4)6-11(9)26-15/h5-7,26H,1-4H3,(H,23,29)(H2,22,24,25)
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n/an/a 16.8n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488395
PNG
(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Show SMILES COCCn1ccc(NC(=O)c2ccc3c(Cl)c([nH]c3c2)-c2nn(c3ncnc(N)c23)C(C)(C)C)n1
Show InChI InChI=1S/C24H26ClN9O2/c1-24(2,3)34-22-17(21(26)27-12-28-22)19(32-34)20-18(25)14-6-5-13(11-15(14)29-20)23(35)30-16-7-8-33(31-16)9-10-36-4/h5-8,11-12,29H,9-10H2,1-4H3,(H2,26,27,28)(H,30,31,35)
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n/an/a 17.1n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM488361
PNG
(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Show SMILES CNC(=O)c1ccc2cc([nH]c2c1)-c1nn(c2ncnc(N)c12)C(C)(C)C
Show InChI InChI=1S/C19H21N7O/c1-19(2,3)26-17-14(16(20)22-9-23-17)15(25-26)13-7-10-5-6-11(18(27)21-4)8-12(10)24-13/h5-9,24H,1-4H3,(H,21,27)(H2,20,22,23)
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n/an/a 17.2n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...


US Patent US10954241 (2021)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%