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Found 8 Enz. Inhib. hit(s) with all data for entry = 102
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174013(4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piper...)
Affinity DataIC50:  75nMpH: 9.0Assay Description:T84 frozen cell pellets or transfected SK-N-MC cells (contents of 1×15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174013(4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piper...)
Affinity DataIC50:  320nMpH: 9.0Assay Description:Transfected SK-N-MC cells (contents of 1×15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0.2% Glycerol,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM188461(US9169224, 150 | US9688664, Comparator Compound)
Affinity DataIC50:  340nMpH: 9.0Assay Description:T84 frozen cell pellets or transfected SK-N-MC cells (contents of 1×15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM188461(US9169224, 150 | US9688664, Comparator Compound)
Affinity DataIC50:  450nMpH: 9.0Assay Description:Transfected SK-N-MC cells (contents of 1×15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0.2% Glycerol,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM188461(US9169224, 150 | US9688664, Comparator Compound)
Affinity DataIC50:  2.00E+3nMpH: 7.4Assay Description:The assay was set up and executed using a Biomek FXp robotic liquid handling workstation (Beckman Coulter Corp., Fullerton, Calif.), integrated with ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM188461(US9169224, 150 | US9688664, Comparator Compound)
Affinity DataIC50:  3.20E+3nMpH: 7.4Assay Description:The assay was set up and executed using a Biomek FXp robotic liquid handling workstation (Beckman Coulter Corp., Fullerton, Calif.), integrated with ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174013(4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piper...)
Affinity DataIC50:  1.10E+4nMpH: 7.4Assay Description:The assay was set up and executed using a Biomek FXp robotic liquid handling workstation (Beckman Coulter Corp., Fullerton, Calif.), integrated with ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174013(4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piper...)
Affinity DataIC50:  2.40E+4nMpH: 7.4Assay Description:The assay was set up and executed using a Biomek FXp robotic liquid handling workstation (Beckman Coulter Corp., Fullerton, Calif.), integrated with ...More data for this Ligand-Target Pair
In DepthDetails US Patent