Compile Data Set for Download or QSAR
maximum 50k data
Found 7 Enz. Inhib. hit(s) for PDB: 1MZC
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50143599(2-[3-(3-ETHYL-1-METHYL-2-OXO-AZEPAN-3-YL)-PHENOXY]...)
Affinity DataIC50:  0.0600nMAssay Description:Inhibitory concentration against farnesyltransferase was determinedMore data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50130367((RR)-4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethy...)
Affinity DataIC50:  0.380nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
LigandPNGBDBM50143599(2-[3-(3-ETHYL-1-METHYL-2-OXO-AZEPAN-3-YL)-PHENOXY]...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition binding constant Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
LigandPNGBDBM50143599(2-[3-(3-ETHYL-1-METHYL-2-OXO-AZEPAN-3-YL)-PHENOXY]...)
Affinity DataIC50:  3.60nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
LigandPNGBDBM50130367((RR)-4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethy...)
Affinity DataIC50:  5.10nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
LigandPNGBDBM50143599(2-[3-(3-ETHYL-1-METHYL-2-OXO-AZEPAN-3-YL)-PHENOXY]...)
Affinity DataEC50:  470nMAssay Description:Inhibition of Rap1a protein geranylgeranylation in human PSN1 cellsMore data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366477(CHEMBL69330)
Affinity DataKd:  2nMAssay Description:Binding affinity to FTase (unknown origin)More data for this Ligand-Target Pair