Found 53 Enz. Inhib. hit(s) for PDB: 1PQC 
Affinity DataKi: 17nMAssay Description:Displacement of radiolabeled T0901317 from LXRbeta LBD (unknown origin)More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 9nMAssay Description:Binding affinity at human LXRbetaMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Displacement of [3H]TO901317 from human recombinant LXRbeta expressed in Escherichia coli by flashplate methodMore data for this Ligand-Target Pair
Affinity DataIC50: 9nM EC50: 16nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRbeta coated flash plates. Each concentration of ...More data for this Ligand-Target Pair
Affinity DataIC50: 9nM EC50: 170nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Binding affinity to human recombinant LXRbeta ligand binding domainMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Displacement of [3H]T0901317 from LXRbeta ligand binding domainMore data for this Ligand-Target Pair
Affinity DataIC50: 10nM EC50: 16nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRbeta LBDMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRbeta-LBDMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRbeta LBDMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Displacement of [N-methyl-3H]T1317 from human biotinylated LXRbeta LBD after 3 hrs by LEAD seeker binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRbeta ligand binding domainMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Binding affinity to LXRbeta by radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Displacement of [3H]N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-methylbenzenesulfonamide from LXRbeta by scintillation proximity assa...More data for this Ligand-Target Pair
Affinity DataIC50: 9.00E+3nMAssay Description:Displacement of [3H]T0901317 from human recombinant N-terminal biotinylated tagged LXRbeta ligand binding domain (154-461) expressed in Escherichia c...More data for this Ligand-Target Pair
TargetOxysterols receptor LXR-alpha/LXR-beta(Homo sapiens (Human))
The University Of Tokyo
Curated by ChEMBL
The University Of Tokyo
Curated by ChEMBL
Affinity DataIC50: 2.60E+4nMAssay Description:Transrepression activity of LXR in human THP1 cells assessed as inhibition of LPS-induced IL-6 level after 18 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 4.70nMAssay Description:Agonist activity at LXRbeta by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 90nMAssay Description:Transactivational agonist activity at human LXRbeta transfected in HEK293 cells expressing CMX-Gal4N assessed as luciferase activity after 16 hrs by ...More data for this Ligand-Target Pair
Affinity DataEC50: 85nMAssay Description:Agonist activity at human LXRbeta expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 140nMAssay Description:Transactivation of LXRbeta (unknown origin) expressed in CV1 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 160nMAssay Description:Agonist activity at LXRbeta (unknown origin) expressed in HEK293 cells assessed as transcriptional activity by GAL4 NR reporter cell-based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 410nMAssay Description:Agonist activity at Gal4-tagged LXRbeta (unknown origin) expressed in CHOK1 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 400nMAssay Description:Agonist activity at LXRbeta (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 130nMAssay Description:Agonist activity at human LXRbeta expressed in African green monkey kidney CV1 cells co-expressing pTAL-LXRE including LXR response element incubated...More data for this Ligand-Target Pair
Affinity DataEC50: 66nMAssay Description:Agonist activity at human LXR-beta transfected in HEK293 cells after 16 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 230nMAssay Description:Agonist activity at human LXRbeta transfected in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:As used herein, reference to the activity of an LXR agonist at LXRα and LXRβ refer to the activity as measured using the ligand sensing ass...More data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Agonist activity at LXRbeta (unknown origin) expressed in human H4 cells co-expressing ABCA1 promoter measured after 48 hrs by cell-based transactiva...More data for this Ligand-Target Pair
Affinity DataEC50: 410nMAssay Description:Agonist activity at GAL4 fused LXRbeta-LBD (unknown origin) transfected in CHOK1 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 156nMAssay Description:Agonist activity at GAL4-fused human LXRbeta expressed in HEK293T cells assessed as activation of basal transcriptional activity after 20 hrs by dual...More data for this Ligand-Target Pair
Affinity DataEC50: 103nMAssay Description:Agonist activity at human LXRbeta-LBD assessed as recruitment of co-activator peptide after 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 103nMAssay Description:Binding affinity to human LXRbeta-LBD by surface plasmon resonanceMore data for this Ligand-Target Pair
Affinity DataEC50: 800nMAssay Description:Partial agonist activity at recombinant human GAL4-DBD-fused LXRbeta-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo luciferas...More data for this Ligand-Target Pair
Affinity DataEC50: 21nMAssay Description:Agonist activity at human LXRbeta expressed in HEK293 cells co-expressing CMX-beta-galactosidase incubated for 16 hrs by luciferase reporter gene ass...More data for this Ligand-Target Pair
Affinity DataEC50: 110nMAssay Description:Agonist activity at human LXR-beta assessed as increase in recruitment of Trap 220/D22 coactivator peptide by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Agonist activity at LXRbeta ligand binding domain-mediated transcriptional activity in african green monkey CV1 cells co-transfected with Gal4-SRC1 b...More data for this Ligand-Target Pair
Affinity DataEC50: 135nMAssay Description:Agonist activity at human Gal4-LBD fused LXRbeta LBD expressed in Huh7 cells by transient transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 19nMAssay Description:Agonist activity at human LXRbeta in HEK293 cells assessed as Gal4 transactivationMore data for this Ligand-Target Pair
Affinity DataEC50: 170nMAssay Description:Agonist activity at human recombinant LXRbeta ligand binding domain in human HuH7 cells cotransfected with fused Gal4-DBD by transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 53nMAssay Description:Agonist activity at human LXRalpha in HEK293 cells assessed as Gal4 transactivationMore data for this Ligand-Target Pair
Affinity DataEC50: 140nMAssay Description:Agonist activity at human recombinant LXRalpha ligand binding domain in human HuH7 cells cotransfected with fused Gal4-DBD by transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 170nMAssay Description:Agonist activity at human LXRbeta ligand binding domain expressed in human HuH7 cells co-transfected with Gal4-DBD by transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 170nMAssay Description:Agonist activity at human recombinant LXRbeta ligand binding domain in HuH7 cells by Gal4 transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 75nMAssay Description:Agonist activity at human LXRbeta expressed in human SH-SY5Y cells co-transfected with Gal4-LBD after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 8nMAssay Description:Agonist activity at LXRbeta ligand binding domain (unknown origin) by FRET based SRC1 recruitment assayMore data for this Ligand-Target Pair
Affinity DataEC50: 178nMAssay Description:Agonist activity at human LXRbeta ligand binding domain (219-462) expressed in human HuH7 cells cotransfected with Gal4-DBD by luciferase transactiva...More data for this Ligand-Target Pair
Affinity DataEC50: 178nMAssay Description:Agonist activity at human LXRbeta expressed in Huh7 cells by Gal4 transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 120nMAssay Description:Agonist activity at human LXR-beta expressed in HEK293 cells after 16 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 300nMAssay Description:Transactivation of LXRbeta by luciferase reporter gene assayMore data for this Ligand-Target Pair
