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Found 9 Enz. Inhib. hit(s) for PDB: 1XUD
TargetCollagenase 3(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM16596(4-N,6-N-bis[(4-fluoro-3-methylphenyl)methyl]pyrimi...)
Affinity DataIC50:  0.670nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM16596(4-N,6-N-bis[(4-fluoro-3-methylphenyl)methyl]pyrimi...)
Affinity DataIC50:  0.670nMAssay Description:Inhibition of MMP13 (unknown origin) using acetyl-Pro-Leu-Gly-[2-mercapto-4-methylpentanoyl]-Leu-Gly-O-ethyl ester as substrate by microplate reader ...More data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM16596(4-N,6-N-bis[(4-fluoro-3-methylphenyl)methyl]pyrimi...)
Affinity DataIC50:  8nMpH: 7.5 T: 2°CAssay Description:MMP-13 was assayed its proteolytic activity using a quenched fluorogenic substrate. The substrate hydrolysis was monitored by recording the increase ...More data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM16596(4-N,6-N-bis[(4-fluoro-3-methylphenyl)methyl]pyrimi...)
Affinity DataIC50:  8nMAssay Description:Inhibition of MMP13 (unknown origin)More data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM16596(4-N,6-N-bis[(4-fluoro-3-methylphenyl)methyl]pyrimi...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant MMP13 expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM16596(4-N,6-N-bis[(4-fluoro-3-methylphenyl)methyl]pyrimi...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human MMP13More data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM16596(4-N,6-N-bis[(4-fluoro-3-methylphenyl)methyl]pyrimi...)
Affinity DataIC50:  8nMAssay Description:Inhibition of MMP13 (unknown origin) using MCA-Arg-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-Glu-Arg-NH2 as substrate preincubated for 15 mins followed by substrat...More data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM16596(4-N,6-N-bis[(4-fluoro-3-methylphenyl)methyl]pyrimi...)
Affinity DataIC50:  70nMAssay Description:Inhibition of full-length recombinant human MMP-13 assessed as bovine type-2 collagen hydrolysis after 18 hrs by ELISAMore data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM16596(4-N,6-N-bis[(4-fluoro-3-methylphenyl)methyl]pyrimi...)
Affinity DataIC50:  110nMAssay Description:Non-competitive inhibition of full-length recombinant human MMP-13 assessed as fTHP-15 substrate hydrolysisMore data for this Ligand-Target Pair