Compile Data Set for Download or QSAR
maximum 50k data
Found 6 Enz. Inhib. hit(s) for PDB: 2VCX
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21625(2-phenyl-5-(1H-pyrazol-3-yl)-1,3-thiazole | 2-phen...)
Affinity DataIC50:  21nMpH: 7.2 T: 2°CAssay Description:The PGDS glutathione-S-transferase (GST) activity was measured by using MonoChloroBimane (MCB) as a chromogenic substrate. The assay was run at 384-w...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21625(2-phenyl-5-(1H-pyrazol-3-yl)-1,3-thiazole | 2-phen...)
Affinity DataIC50:  23nMAssay Description:Inhibition human HPGDS expressed in Escherichia coli assessed as reduction in GST enzymatic activity using MCBL and glutathione incubated for 30 mins...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21625(2-phenyl-5-(1H-pyrazol-3-yl)-1,3-thiazole | 2-phen...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assayMore data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21625(2-phenyl-5-(1H-pyrazol-3-yl)-1,3-thiazole | 2-phen...)
Affinity DataKd:  51nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21625(2-phenyl-5-(1H-pyrazol-3-yl)-1,3-thiazole | 2-phen...)
Affinity DataKd:  300nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21625(2-phenyl-5-(1H-pyrazol-3-yl)-1,3-thiazole | 2-phen...)
Affinity DataEC50:  110nMAssay Description:Inhibition HPGDS in human MEG01 cells assessed as reduction in PGD2 production incubated for 30 mins followed by stimulation with 5 uM ionomycin for ...More data for this Ligand-Target Pair