Found 51 Enz. Inhib. hit(s) for PDB: 3CZV TargetCarbonic anhydrase 1/12/13/14/2/3/4/5A, mitochondrial/5B, mitochondrial/6/7/9(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataKi: 0.800nMAssay Description:Compound was evaluated for the inhibition of Carbonic anhydrase (Non competitive)More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 5.70nMAssay Description:Inhibition of human recombinant carbonic anhydrase 13 preincubated for 15 mins by CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Inhibition of human recombinant carbonic anhydrase 13 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 16nMpH: 7.5Assay Description:Reactions were measured using 0.2 mM phenol red (Absmax at 557 nm) as the indicator, in 10 mM HEPES, 0.1 M Na2SO4, pH 7.5, for a period of 10-100 s. ...More data for this Ligand-Target Pair
Affinity DataKi: 17nM ΔG°: -43.6kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of human CA13 preincubated for 15 mins by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of human carbonic anhydrase13 preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of recombinant human CA13 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydra...More data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of human CA13 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of human recombinant CA13 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of full length mouse carbonic anhydrase 13 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of mouse CA13 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of human recombinant carbonic anhydrase 13 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of mouse recombinant full length CA13 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of mouse full length carbonic anhydrase 13 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of mouse carbonic anhydrase 13More data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Ki value against mouse carbonic anhydrase XIIIMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Ki value against mouse carbonic anhydrase XIIIMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibitory activity against murine carbonic anhydrase XIII (mCA XIII) by using CO2 hydrase assay methodMore data for this Ligand-Target Pair
Affinity DataKi: 17nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase 13 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of human recombinant cytosolic carbonic anhydrase 13 preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of carbonic anhydrase-13 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 17nM ΔG°: -41.2kJ/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of...More data for this Ligand-Target Pair
Affinity DataKi: 18nMAssay Description:Inhibition of human recombinant carbonic anhydrase 13 pre-incubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 21nMpH: 7.5Assay Description:Reactions were measured using 0.2 mM phenol red (Absmax at 557 nm) as the indicator, in 10 mM HEPES, 0.1 M Na2SO4, pH 7.5, for a period of 10-100 s. ...More data for this Ligand-Target Pair
Affinity DataKi: 163nMpH: 7.5Assay Description:Reactions were measured using 0.2 mM phenol red (Absmax at 557 nm) as the indicator, in 10 mM HEPES, 0.1 M Na2SO4, pH 7.5, for a period of 10-100 s. ...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 13 + BH(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital
University Of Tampere And Tampere University Hospital
Affinity DataKi: 164nMpH: 7.5Assay Description:Reactions were measured using 0.2 mM phenol red (Absmax at 557 nm) as the indicator, in 10 mM HEPES, 0.1 M Na2SO4, pH 7.5, for a period of 10-100 s. ...More data for this Ligand-Target Pair
Affinity DataKi: 174nMpH: 7.5Assay Description:Reactions were measured using 0.2 mM phenol red (Absmax at 557 nm) as the indicator, in 10 mM HEPES, 0.1 M Na2SO4, pH 7.5, for a period of 10-100 s. ...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 13 + BH(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital
University Of Tampere And Tampere University Hospital
Affinity DataKi: 179nMpH: 7.5Assay Description:Reactions were measured using 0.2 mM phenol red (Absmax at 557 nm) as the indicator, in 10 mM HEPES, 0.1 M Na2SO4, pH 7.5, for a period of 10-100 s. ...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 1/12/13/14/2/3/4/5A, mitochondrial/5B, mitochondrial/6/7/9(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 440nMAssay Description:Inhibition of Carbonic anhydrase enzyme in rabbitsMore data for this Ligand-Target Pair
Affinity DataIC50: 490nMAssay Description:Inhibition of mouse carbonic anhydrase 13 assessed as 4-nitrophenyl acetate hydrolysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of mouse carbonic anhydrase 13 assessed as 4-nitrophenyl phosphate hydrolysisMore data for this Ligand-Target Pair
Affinity DataKd: 50nMAssay Description:Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assayMore data for this Ligand-Target Pair
Affinity DataKd: 50nMpH: 7.0Assay Description:Binding affinity to human recombinant CA13 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
Affinity DataKon: 0.0150M-1s-1Assay Description:Binding affinity to human N-terminal full length His-tagged CA13 (1 to 262 residues) expressed in Escherichia coli BL21(DE3) assessed as dissociation...More data for this Ligand-Target Pair
Affinity DataKd: 36.5nMAssay Description:Binding affinity to human N-terminal full length His-tagged CA13 (1 to 262 residues) expressed in Escherichia coli BL21(DE3) assessed as thermodynami...More data for this Ligand-Target Pair
Affinity DataKd: 10nMAssay Description:Binding affinity to human N-terminal full length His-tagged CA13 (1 to 262 residues) expressed in Escherichia coli BL21(DE3) assessed as intrinsic th...More data for this Ligand-Target Pair
Affinity DataKd: <10nMAssay Description:Inhibition of human carbonic anhydrase 13 at pH7 and 25 degC by stopped-flow kinetic inhibition assayMore data for this Ligand-Target Pair
Affinity DataKd: 60nMAssay Description:Inhibition of human carbonic anhydrase 13 at pH7 and 37 degC by isothermal titration calorimetryMore data for this Ligand-Target Pair
Affinity DataKd: 50nMAssay Description:Inhibition of human carbonic anhydrase 13 at pH7 and 37 degC by fluorescent thermal shift assayMore data for this Ligand-Target Pair
Affinity DataKd: 50nMpH: 7.0Assay Description:The thermal shift assay (TSA) measurements were performed in a Corbett Rotor-Gene 6000 (QIAGEN Rotor-Gene Q, Sydney, Australia) instrument using the ...More data for this Ligand-Target Pair
Affinity DataKon: 0.0150M-1s-1Assay Description:Binding affinity to human N-terminal full length His-tagged CA13 (1 to 262 residues) expressed in Escherichia coli BL21(DE3) assessed as intrinsic di...More data for this Ligand-Target Pair
Affinity DataKd: 50nMAssay Description:Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assayMore data for this Ligand-Target Pair
Affinity DataKd: 23nMAssay Description:Binding affinity to recombinant human full length N-terminal His-tagged carbonic anhydrase 13 (1 to 262 residues) expressed in Escherichia coli BL21 ...More data for this Ligand-Target Pair
Affinity DataKd: 50nMAssay Description:Binding affinity to recombinant human full length N-terminal His-tagged carbonic anhydrase 13 (1 to 262 residues) expressed in Escherichia coli BL21 ...More data for this Ligand-Target Pair
