TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKi: 45nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKi: 45nMAssay Description:Inhibition of C-terminal His-tagged human recombinant full-length HDAC8 expressed in baculovirus expression system assessed as reduction in 7-amino-4...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKi: 70nMAssay Description:Inhibition of human recombinant HDAC8 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKi: 130nMAssay Description:Inhibition of recombinant HDAC8More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKi: 145nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC8 (1 to 377 residues) expressed in baculovirus-infected insect cells using RHK(Ac)K(Ac)AMC ...More data for this Ligand-Target Pair
Affinity DataKi: 504nMAssay Description:Inhibition of HDAC in human Hela cells nuclear extracts by fluorimetric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 1.38nMAssay Description:Inhibition of HDAC8 (unknown origin) after 17 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using BML-KI104 Fluor de Lys as substrate by fluorescence-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of HDAC in human HeLa cells using Ac-Arg-Gly-Lys(Ac)-AMC as fluorescent substrate after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Inhibitory activity against Histone deacetylase (HDAC) in K 562 erythroleukemia cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibitory activity against partially purified histone deacetylase of human leukemia K562 cells.More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of histone deacetylase (HDAC) activity in HeLa cell nuclear extractMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human HDAC in HeLa cells by flour de lys assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extracts after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMAssay Description:Inhibition of HDAC in human HeLa cell extract after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human HDAC after 30 minsMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of human recombinant HDAC8 after 30 mins by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Concentration required to inhibit human Histone deacetylase (HDAC) enzyme by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) enzyme obtained from H1299 human lung carcinoma cell lysatesMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of human HDAC in human HeLa cell nuclear extract after 15 mins by colorimetric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of human histone deacetylase 8 prepared from 293T cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibitory activity against histone deacetylase 8 prepared from mouse melanoma B16/BL6 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Inhibitory activity against Histone deacetylase (HDAC) from SNU-16 (human gastric adenocarcinoma) cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Inhibitory concentration against human histone deacetylase (HDAC) from HeLa cells with substrate 5aMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 70.1nMpH: 8.0Assay Description:Briefly, recombinant HDACs and substrates were diluted in reaction buffer (50 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7mM KCl, 1mM MgCl2, 1 mg/ml BSA, 1%...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of human HDAC8 by fluorimetric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of human HDAC8 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of HDAC8 by in vitro deacetylation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Concentration required to inhibit the partially purified HDAC enzyme by 50% obtained from H1299 cell lysateMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 125nMAssay Description:Inhibition of HDAC8 (unknown origin) by ELISAMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of HDAC8 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence methodMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 165nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of HDAC8 (unknown origin) using RHK(Ac)K(Ac) fluorogenic acetylated peptide substrate by fluorometric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 196nMAssay Description:Inhibition of human HDAC8 by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 213nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 307nMAssay Description:Inhibition of human recombinant C-terminal His-tagged HDAC8 (1 to 377 residues) expressed in insect cells using RHK-K(Ac)-K(Ac)-AMC as substrate incu...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 314nMAssay Description:Inhibition of recombinant human HDAC8 using fluorogenic substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 360nMAssay Description:Inhibition of recombinant human HDAC8 by fluorimetryMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 390nMAssay Description:Inhibition of human recombinant HDAC8 using fluor de Lys as substrate preincubated for 5 mins followed by substrate addition measured after 25 mins b...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 472nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 566nMAssay Description:Inhibition of human HDAC8 using RHKAcKAc peptide as substrateMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 609nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC8 expressed in baculovirus infected insect cells using RHKK(Ac)AMC as substrate by fluoresc...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 770nMAssay Description:Inhibition of human recombinant histone deacetylase 8More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 960nMAssay Description:Inhibition of N terminal hexahistidine-tagged human HDAC8 expressed in Sf9 cells after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of human HDAC8 using RHKAcKAc as substrateMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of HDAC8 (unknown origin) after 30 mins by fluorometric analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 1.38E+3nMAssay Description:Inhibition of HDAC8 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrsMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 1.38E+3nMAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair