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Found 3 Enz. Inhib. hit(s) for PDB: 3K47
TargetDihydrofolate reductase(Mus musculus (Mouse))
Duquesne University

LigandPNGBDBM33394(2,4-diaminofuro[2,3-d]pyrimidine, 1a | E-isomer)
Affinity DataIC50:  1.45E+4nMAssay Description:Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

LigandPNGBDBM33394(2,4-diaminofuro[2,3-d]pyrimidine, 1a | E-isomer)
Affinity DataIC50:  1.64E+4nMAssay Description:Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

LigandPNGBDBM33394(2,4-diaminofuro[2,3-d]pyrimidine, 1a | E-isomer)
Affinity DataIC50:  1.85E+4nMAssay Description:Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...More data for this Ligand-Target Pair