Found 90 Enz. Inhib. hit(s) for PDB: 3S3V TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataKi: 0.00600nMAssay Description:Binding affinity to DHFR (unknown origin) by NMR analysisMore data for this Ligand-Target Pair
3D Structure (crystal)TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataKi: 10nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataKi: 120nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Leishmania major.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataKi: 195nMAssay Description:Inhibition of human dihydrofolate reductase (DHFR) enzymeMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataKi: 1.00E+3nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Trypanosoma cruzi.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataKi: 1.38E+3nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
Affinity DataKi: 3.09E+3nMpH: 7.2Assay Description:Inhibition of Wnt2/beta-catenin signaling in human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.09E+3nMpH: 7.2Assay Description:Inhibitory activity against bovine liver dihydrofolate reductase at pH 7.2.More data for this Ligand-Target Pair
Affinity DataKi: 3.09E+3nMAssay Description:Inhibition of dihydrofolate reductase from bovine liverMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataKi: 1.91E+4nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataKi: 1.91E+4nMAssay Description:Inhibition of human DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometric analysis in p...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataKi: 4.58E+4nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in NADPH oxidation using dihydrofolate as substrate preincubated for 5 mins followed by su...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataKi: 4.80E+4nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Antibacterial activity of the compound against TMP-Resistant Dihydrofolate reductase from Staphylococcus aureus 157/4696More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Concentration required to inhibit the Pneumocystis carinii Dihydrofolate reductase by 50% was determined (reported by workers at Hoffman-LaRoche)More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 54nMAssay Description:Inhibitory activity against Dihydrofolate reductase from recombinant human (hDHFR)More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:Inhibitory activity of the compound against TMP-susceptible DHFR from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 123nMAssay Description:Inhibition of DHFR using dihydrofolate as substrate following 3 mins substrate preincubation measured after 3 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 144nMAssay Description:Inhibition of bovine liver DHFR using FH2 as substrate preincubated for 2 mins followed by substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 144nMAssay Description:Inhibition of bovine liver DHFR using FH2 as substrate preincubated for 2 mins followed by substrate addition in presence of NADPHMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibitory concentration against dihydrofolate reductase of Mycobacterium aviumMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determined; Range : 260-350More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Concentration required to inhibit the human Dihydrofolate reductase by 50% was determined (reported by workers at Hoffman-LaRoche)More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Concentration required to inhibit the human Dihydrofolate reductase by 50% was determined (reported by workers at Hoffman-LaRoche)More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibitory concentration against dihdrofolate reductace enzyme of Cryptosporium parvum of bovine originMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibitory concentration against dihydrofolate reductase of Toxoplasma gondiiMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 2.80E+3nMAssay Description:Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determined; Range : 2400-3300More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Antibacterial activity of the compound against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 3.40E+3nMAssay Description:Compound was evaluated as inhibitor of human Dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibitory concentration against dihdrofolate reductace enzyme of Cryptosporium parvum of human originMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibitory concentration against dihdrofolate reductace enzyme of Pneumocystis cariniiMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 1.30E+4nMAssay Description:Concentration required to inhibit the Pneumocystis carinii Dihydrofolate reductase by 50% was determined; Range : 10000-16000More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 1.90E+4nMAssay Description:Tested for inhibition of TMP-Resistant Dihydrofolate reductase from Staphylococcus aureus 157/4696.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 2.45E+4nMAssay Description:Inhibition of human recombinant DHFR expressed in Escherichia coli Rosetta Gami B (DE3) competent cells using DHFA as substrate and NADPHMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 3.22E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibitory activity against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibitory concentration against rat liver (RL) dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human DHFR assessed as NADPH consumption for conversion of dihydrofolic acid to tetrahydrofolic acid after 6 mins every 5 sec by UV-Vis...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 1.20E+5nMAssay Description:Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH oxidation at an absorbance of 340 nm over several minutes. All...More data for this Ligand-Target Pair
Affinity DataIC50: 1.21E+5nMAssay Description:Inhibitory concentration against dihydrofolate reductase DHFR from rat liver.More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+5nMAssay Description:The ability of the compound to inhibit rat liver Dihydrofolate reductase was testedMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+5nMAssay Description:Compound was tested for inhibition activity against rat liver lipophilic Dihydrofolate reductase (DHFR).More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+5nMAssay Description:Inhibition of rat liver Dihydrofolate ReductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+5nMAssay Description:Inhibitory activity against rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+5nMAssay Description:Concentration inhibiting rat liver dihydrofolate reductase .More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+5nMAssay Description:Inhibitory activity of the compound against DHFR(Dihydrofolate reductase) from Rat liver .More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+5nMAssay Description:Inhibitory activity against rat liver Dihydrofolate reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+5nMAssay Description:Inhibition of Dihydrofolate reductase (DHFR) of in rat liverMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+5nMAssay Description:Inhibition of partially purified dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
