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Found 5 Enz. Inhib. hit(s) for PDB: 4CV1
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
University Of Wuerzburg

LigandPNGBDBM231620(CG400549 | US10071965, Compound CG400549)
Affinity DataKi:  1.30nMpH: 7.5Assay Description:Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20 °C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...More data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
The Research Foundation For The State University Of New York

US Patent
LigandPNGBDBM231620(CG400549 | US10071965, Compound CG400549)
Affinity DataKi:  1.30nM ΔG°:  -50.7kJ/molepH: 7.5 T: 2°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
The Research Foundation For The State University Of New York

US Patent
LigandPNGBDBM231620(CG400549 | US10071965, Compound CG400549)
Affinity DataKi:  4.70nMpH: 7.5Assay Description:Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20° C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...More data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
The Research Foundation For The State University Of New York

US Patent
LigandPNGBDBM231620(CG400549 | US10071965, Compound CG400549)
Affinity DataKi:  81.9nM ΔG°:  -40.4kJ/molepH: 7.5 T: 2°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
The Research Foundation For The State University Of New York

US Patent
LigandPNGBDBM231620(CG400549 | US10071965, Compound CG400549)
Affinity DataKi:  99.4nMpH: 7.5Assay Description:Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20° C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...More data for this Ligand-Target Pair