Compile Data Set for Download or QSAR
maximum 50k data
Found 3 Enz. Inhib. hit(s) for PDB: 4OGN
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50008749(CHEMBL3236356)
Affinity DataIC50:  0.100nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50008749(CHEMBL3236356)
Affinity DataIC50:  0.800nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50008749(CHEMBL3236356)
Affinity DataIC50:  5nMAssay Description:Binding affinity to MDM2 in human SJSA1 cells assessed as induction of p21 expressionMore data for this Ligand-Target Pair