Compile Data Set for Download or QSAR
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Found 3 Enz. Inhib. hit(s) for PDB: 4YL1
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313224(5-(4-tert-butylphenyl)-1-(4-isopropoxyphenyl)-1H-i...)
Affinity DataIC50:  62nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313224(5-(4-tert-butylphenyl)-1-(4-isopropoxyphenyl)-1H-i...)
Affinity DataIC50:  216nMAssay Description:Inhibition of recombinant human mPGES-1 expressed in human 293E cell microsomes using PGH2 as substrate assessed as PGE2 production after 2.5 mins by...More data for this Ligand-Target Pair
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313224(5-(4-tert-butylphenyl)-1-(4-isopropoxyphenyl)-1H-i...)
Affinity DataIC50:  2.58E+3nMAssay Description:Inhibition of purified mPGES-1 (1 to 152) (unknown origin) extracted from detergent-solubilized baculovirus-infected insect Sf9 cell membranes using ...More data for this Ligand-Target Pair