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Found 8 Enz. Inhib. hit(s) for PDB: 4ZVV
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM197160(GNE-140 (6))
Affinity DataIC50:  3nMAssay Description:LDHA, LDHB, LDHC, MDH1 and MDH2 enzymatic assays have been described in detail previously [Dragovich, P.S. et al, Bioorg. Med. Chem. Lett. 24:3764-37...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM197160(GNE-140 (6))
Affinity DataIC50: <10nMAssay Description:Inhibition of human liver LDHA using sodium pyruvate as substrate after 5 mins in presence of NAPDH and EDTA by diaphorase/resazurin based fluorescen...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM197160(GNE-140 (6))
Affinity DataIC50:  424nMAssay Description:Inhibition of human liver LDHA using sodium pyruvate as substrate after 5 mins in presence of NAPDH and EDTA by diaphorase/resazurin based fluorescen...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM197160(GNE-140 (6))
Affinity DataIC50:  424nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM197160(GNE-140 (6))
Affinity DataIC50:  877nMAssay Description:Inhibition of LDH in human MIAPaCa2 cells assessed as reduction in lactate production preincubated for 2 hrs measured after 30 mins by high throughpu...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM197160(GNE-140 (6))
Affinity DataIC50:  1.44E+3nMAssay Description:Inhibition of human liver LDHA using sodium pyruvate as substrate after 5 mins in presence of NAPDH and EDTA by diaphorase/resazurin based fluorescen...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM197160(GNE-140 (6))
Affinity DataEC50:  7.20nMAssay Description:Inhibition of human LDH5 using pyruvate as substrate after 10 minsMore data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM197160(GNE-140 (6))
Affinity DataEC50:  1.26E+3nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair