BindingDB PrimarySearch

Found 13 Enz. Inhib. hit(s) for PDB: 5D7P

NAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL

BDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)

IC50: 1.94E+3nMAssay Description:Inhibition of full length human SIRT2 expressed in Escherichia coli BL21 (DE3) cells using fluorogenic 7-amino-4-methylcoumarin (AMC)-labeled peptide...More data for this Ligand-Target Pair

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3D Structure (crystal)

NAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL

BDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)

IC50: 2.90E+3nMAssay Description:Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrat...More data for this Ligand-Target Pair

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3D Structure (crystal)

NAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL

BDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)

IC50: 6.50E+3nMAssay Description:Inhibition of His-tagged human recombinant SIRT2 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

NAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL

BDBM50309833((S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-car...)

IC50: >1.00E+4nMAssay Description:Inhibition of human recombinant SIRT2 by Flour de Lys assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

NAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL

BDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)

IC50: 1.40E+4nMAssay Description:Inhibition of SIRT2More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

NAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL

BDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)

IC50: 1.40E+4nMAssay Description:Inhibition of recombinant SIRT2 (unknown origin) preincubated for 5 mins before addition of substrate measured after 3 hrs by fluorescence-based assa...More data for this Ligand-Target Pair

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3D Structure (crystal)

NAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL

BDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)

IC50: 1.96E+4nMAssay Description:Inhibition of recombinant human full length SIRT2 using fluorescent ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetylase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

NAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL

BDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)

IC50: 1.96E+4nMAssay Description:Inhibitory activity against recombinant human SIRT2 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

NAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL

BDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)

IC50: 1.96E+4nMAssay Description:Inhibition of human recombinant GST-tagged SIRT2 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

NAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL

BDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)

IC50: 2.00E+4nMAssay Description:Inhibition of recombinant SIRT2 using ZMAL substrate after 4 hrs by homogeneous fluorescence assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

NAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL

BDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)

IC50: 2.00E+4nMAssay Description:Inhibition of SIRT2More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

NAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL

BDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)

IC50: 2.01E+4nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-2 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

NAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL

BDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)

IC50: 4.85E+4nMAssay Description:Inhibition of human recombinant SIRT2 expressed in Escherichia coli cells using acetylated Lys side chain amino acids 379-382 (Arg-His-Lys-Lys(Ac)) p...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Filter my 13 hits

Targets 1▿
- NAD-dependent protein deacetylase sirtuin-2 13
Publications 13▿
- J Med Chem 55: 8193-7 (2012) 1
- Bioorg Med Chem Lett 25: 2514-8 (2015) 1
- J Med Chem 54: 417-32 (2011) 1
- J Med Chem 57: 8340-57 (2014) 1
- ACS Med Chem Lett 3: 1050-1053 (2012) 1
- J Med Chem 48: 8045-54 (2005) 1
- J Med Chem 60: 4714-4733 (2017) 1
- Bioorg Med Chem 19: 3616-24 (2011) 1
- J Med Chem 53: 1407-11 (2010) 1
- J Med Chem 52: 2153-6 (2009) 1
- J Med Chem 56: 3666-79 (2013) 1
- Bioorg Med Chem Lett 17: 2448-51 (2007) 1
- Medchemcomm (2012) 1
Institutions 11▿
- University Of Kuopio 2
- Sirtris A Gsk 2
- H�Pital Kirchberg 1
- TBA 1
- University Of Minnesota 1
- Sapienza University Of Rome 1
- Methylgene 1
- Elixir Pharmaceuticals 1
- Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences 1
- Imperial College London 1
- Institute Of Psychiatry And Neuroscience Of Paris 1
Affinity: 1.9E+3 to 4.9E+4 nM▿
- IC50 13
- Affinity ≤ nM
Xtal structures: 2
Docked structures: 0
Catalog Cmpds: 2