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Found 5 Enz. Inhib. hit(s) for PDB: 5IVJ
TargetLysine-specific demethylase 5A [1-1090](Homo sapiens (Human))
Emory University

LigandPNGBDBM191597(3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...)
Affinity DataIC50:  74nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM191597(3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...)
Affinity DataIC50: <100nMAssay Description:The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLysine-specific demethylase 5A [1-739](Homo sapiens (Human))
Emory University

LigandPNGBDBM191597(3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...)
Affinity DataIC50:  1.10E+3nMT: 2°CAssay Description:For inhibition assays, powders of inhibitor compounds were dissolved in 100% (v/v) DMSO to give a 20 or 50 mM concentration and stored at -20 °C unti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLysine-specific demethylase 5A [1-588](Homo sapiens (Human))
Emory University

LigandPNGBDBM191597(3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...)
Affinity DataKd:  46nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLysine-specific demethylase 5B [1-604](Homo sapiens (Human))
Emory University

LigandPNGBDBM191597(3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...)
Affinity DataKd:  55nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB