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Found 6 Enz. Inhib. hit(s) for PDB: 5TDF
TargetATP-citrate synthase(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036210((2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid ...)
Affinity DataKi:  150nMAssay Description:Reversible binding potential for rat ATP-Citrate Lyase as carbon-carbon bond cleavage activity in citrate substrateMore data for this Ligand-Target Pair
TargetATP-citrate synthase(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036210((2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid ...)
Affinity DataKi:  150nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
TargetATP-citrate synthase(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036210((2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid ...)
Affinity DataKi:  8.00E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
TargetATP-citrate synthase(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036210((2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid ...)
Affinity DataKi:  8.00E+3nMAssay Description:Inhibition of rat liver ACLY by fluorimetric analysisMore data for this Ligand-Target Pair
TargetATP-citrate synthase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50036210((2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid ...)
Affinity DataKi:  3.00E+5nMAssay Description:Competitive inhibition of human liver ACLY using varying levels of citrate as substrateMore data for this Ligand-Target Pair
TargetATP-citrate synthase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50036210((2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid ...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human recombinant ATP-citrate lyaseMore data for this Ligand-Target Pair