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Found 3 Enz. Inhib. hit(s) for PDB: 6C2I
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM171819(US9085576, 320)
Affinity DataIC50:  15nMAssay Description:Inhibition of BACE1 in HEK293 cellsMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM171819(US9085576, 320)
Affinity DataIC50:  56.5nMpH: 4.2Assay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM171819(US9085576, 320)
Affinity DataIC50:  81nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair