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Found 9 Enz. Inhib. hit(s) for PDB: 6BBU
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM159748(US10966980, Example 2 | US9035074, 2)
Affinity DataIC50:  29nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM159748(US10966980, Example 2 | US9035074, 2)
Affinity DataIC50:  29nMAssay Description:Inhibition of recombinant human JAK1 using 5'FAM-KKSRGDYMTMQID as substrate in presence of 1 mM ATP by mobility shift assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1/JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM159748(US10966980, Example 2 | US9035074, 2)
Affinity DataIC50:  163nMAssay Description:Inhibition of JAK2/JAK1 in human whole blood assessed as reduction in IFNgamma induced STAT1 phosphorylation preincubated for 45 mins followed by IFN...More data for this Ligand-Target Pair
LigandPNGBDBM159748(US10966980, Example 2 | US9035074, 2)
Affinity DataIC50:  163nMAssay Description:Inhibition of JAK1/JAK2/TYK2 in CD14+ human whole blood assessed as reduction in IL-6 induced STAT1 phosphorylation preincubated for 45 mins followed...More data for this Ligand-Target Pair
LigandPNGBDBM159748(US10966980, Example 2 | US9035074, 2)
Affinity DataIC50:  189nMAssay Description:Inhibition of JAK1/TYK2 in human whole blood assessed as reduction in IFNalpha induced STAT3 phosphorylation preincubated for 45 mins followed by IFN...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1/JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM159748(US10966980, Example 2 | US9035074, 2)
Affinity DataIC50:  271nMAssay Description:Inhibition of JAK2/JAK1 in human whole blood assessed as reduction in IL-27 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-27 ...More data for this Ligand-Target Pair
TargetJAK3/JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM159748(US10966980, Example 2 | US9035074, 2)
Affinity DataIC50:  511nMAssay Description:Inhibition of JAK1/JAK3 in human whole blood assessed as reduction in IL-21 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-21 ...More data for this Ligand-Target Pair
TargetJAK3/JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM159748(US10966980, Example 2 | US9035074, 2)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of JAK1/JAK3 in CD8+ human whole blood assessed as reduction in IL-15 induced STAT5 phosphorylation preincubated for 45 mins followed by I...More data for this Ligand-Target Pair
LigandPNGBDBM159748(US10966980, Example 2 | US9035074, 2)
Affinity DataIC50:  2.51E+3nMAssay Description:Inhibition of JAK1/TYK2 in human whole blood assessed as reduction in IL-10 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-10 ...More data for this Ligand-Target Pair