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Found 8 Enz. Inhib. hit(s) for PDB: 6BBV
TargetTyrosine-protein kinase JAK1/JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM159748(US10966980, Example 2 | US9035074, 2)
Affinity DataIC50:  163nMAssay Description:Inhibition of JAK2/JAK1 in human whole blood assessed as reduction in IFNgamma induced STAT1 phosphorylation preincubated for 45 mins followed by IFN...More data for this Ligand-Target Pair
LigandPNGBDBM159748(US10966980, Example 2 | US9035074, 2)
Affinity DataIC50:  163nMAssay Description:Inhibition of JAK1/JAK2/TYK2 in CD14+ human whole blood assessed as reduction in IL-6 induced STAT1 phosphorylation preincubated for 45 mins followed...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1/JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM159748(US10966980, Example 2 | US9035074, 2)
Affinity DataIC50:  271nMAssay Description:Inhibition of JAK2/JAK1 in human whole blood assessed as reduction in IL-27 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-27 ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM159748(US10966980, Example 2 | US9035074, 2)
Affinity DataIC50:  803nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM159748(US10966980, Example 2 | US9035074, 2)
Affinity DataIC50:  803nMAssay Description:Inhibition of recombinant human JAK2 using FITC-KGGEEEEYFELVKK as substrate in presence of 1 mM ATP by mobility shift assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM159748(US10966980, Example 2 | US9035074, 2)
Affinity DataIC50:  7.18E+3nMAssay Description:Inhibition of JAK2 in CD34+ human whole blood assessed as reduction in EOP induced STAT5 phosphorylation preincubated for 45 mins followed by EOP add...More data for this Ligand-Target Pair
LigandPNGBDBM159748(US10966980, Example 2 | US9035074, 2)
Affinity DataIC50:  1.37E+4nMAssay Description:Inhibition of JAK2/TYK2 in human whole blood assessed as reduction in IL-12 induced STAT4 phosphorylation preincubated for 45 mins followed by IL-12 ...More data for this Ligand-Target Pair
LigandPNGBDBM159748(US10966980, Example 2 | US9035074, 2)
Affinity DataIC50: >1.65E+4nMAssay Description:Inhibition of JAK2/TYK2 in human whole blood assessed as reduction in IL-23 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-23 ...More data for this Ligand-Target Pair