Compile Data Set for Download or QSAR
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Found 14 Enz. Inhib. hit(s) with all data for entry = 50009093
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50080064(1-[(Z)-2-Cycloheptyloxy-2-(2,6-dichloro-phenyl)-vi...)
Affinity DataIC50:  110nMAssay Description:Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50080067(1-[(Z)-2-Cycloheptyloxy-2-(2,4-dichloro-phenyl)-vi...)
Affinity DataIC50:  470nMAssay Description:Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50080064(1-[(Z)-2-Cycloheptyloxy-2-(2,6-dichloro-phenyl)-vi...)
Affinity DataIC50:  500nMAssay Description:Inhibition of [3H]-DCG IV binding on rat mGluR2 transfected cell membranes from CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50080069(1-[(Z)-2-Cyclohexyloxy-2-(2,6-dichloro-phenyl)-vin...)
Affinity DataIC50:  580nMAssay Description:Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50080066(1-[(Z)-2-Cyclohexyloxy-2-(2,4-dichloro-phenyl)-vin...)
Affinity DataIC50:  1.05E+3nMAssay Description:Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50080058(1-[(Z)-2-Cyclooctyloxy-2-(2,4-dichloro-phenyl)-vin...)
Affinity DataIC50:  1.21E+3nMAssay Description:Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50080062(1-[(Z)-2-Cycloheptyloxy-2-(4-trifluoromethyl-pheny...)
Affinity DataIC50:  1.38E+3nMAssay Description:Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50080068(1-[(Z)-2-Benzyloxy-2-(2,6-dichloro-phenyl)-vinyl]-...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50080059(1-[(Z)-2-Cyclopentyloxy-2-(2,4-dichloro-phenyl)-vi...)
Affinity DataIC50:  2.55E+3nMAssay Description:Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50080061(1-[(Z)-2-Benzyloxy-2-(2,4-dichloro-phenyl)-vinyl]-...)
Affinity DataIC50:  2.68E+3nMAssay Description:Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50080060(2-[(Z)-2-Butoxy-2-(4-chloro-phenyl)-vinyl]-2H-tetr...)
Affinity DataIC50:  3.16E+3nMAssay Description:Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50080063(1-[(Z)-2-(2,4-Dichloro-phenyl)-2-isopropoxy-vinyl]...)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50080057(1-[(Z)-2-(2,4-Difluoro-phenyl)-2-isopropoxy-vinyl]...)
Affinity DataIC50:  7.50E+4nMAssay Description:Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50080065(1-[(Z)-2-(2,4-Dimethoxy-phenyl)-2-isopropoxy-vinyl...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 1S, 3R-ACPD (10 microM)-stimulated GTP gamma 35S binding on rat mGluR2 transfected cell membranes from CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed