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Found 24 Enz. Inhib. hit(s) with all data for entry = 50010611
Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50087036(6-Methyl-1,5,5a,6,7,8-hexahydro-6-aza-benzo[mno]ac...)
Affinity DataKi:  6.90nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 variant with Y181C plus K103N mutatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50096742((R)-7-Methyl-6a,7,8,9-tetrahydro-6H-2,7-diaza-benz...)
Affinity DataKi:  27nMAssay Description:In vitro binding affinity of the compound towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]-5-HT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50096741((R)-7-Methyl-6a,7,8,9-tetrahydro-6H-1,7-diaza-benz...)
Affinity DataKi:  34nMAssay Description:In vitro binding affinity of the compound towards cloned human 5-hydroxytryptamine 1A receptor expressed in Chinese hamster ovary (CHO) cells using [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50087036(6-Methyl-1,5,5a,6,7,8-hexahydro-6-aza-benzo[mno]ac...)
Affinity DataKi:  41nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 variant with Y181C plus K103N mutatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM29644((6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataKi:  42nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 variant with Y181C plus K103N mutatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(2) dopamine receptor(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50202333((R)-7-Methyl-6a,7,8,9-tetrahydro-2H,6H-2,7-diaza-b...)
Affinity DataKi:  55nMAssay Description:In vitro binding affinity of the compound towards cloned human Dopamine receptor D2A using [3H]- Raclopride as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50202333((R)-7-Methyl-6a,7,8,9-tetrahydro-2H,6H-2,7-diaza-b...)
Affinity DataKi:  55nMAssay Description:In vitro binding affinity of the compound towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]-5-HT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50096742((R)-7-Methyl-6a,7,8,9-tetrahydro-6H-2,7-diaza-benz...)
Affinity DataKi:  62nMAssay Description:In vitro binding affinity of the compound towards cloned human 5-hydroxytryptamine 1A receptor expressed in Chinese hamster ovary (CHO) cells using [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50096741((R)-7-Methyl-6a,7,8,9-tetrahydro-6H-1,7-diaza-benz...)
Affinity DataKi:  81nMAssay Description:In vitro binding affinity of the compound towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]-5-HT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50087036(6-Methyl-1,5,5a,6,7,8-hexahydro-6-aza-benzo[mno]ac...)
Affinity DataKi:  83nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50202333((R)-7-Methyl-6a,7,8,9-tetrahydro-2H,6H-2,7-diaza-b...)
Affinity DataKi:  178nMAssay Description:In vitro binding affinity of the compound towards cloned human 5-hydroxytryptamine 1A receptor expressed in Chinese hamster ovary (CHO) cells using [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM29644((6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataKi:  188nMAssay Description:Non-competitive inhibition against Candida albicans prolyl-tRNA synthetase (Ca. ProRS) with respect to prolineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50096739((R)-7-methyl-6a,7,8,9-tetrahydro-6H-1-oxa-7-aza-be...)
Affinity DataKi:  265nMAssay Description:In vitro binding affinity of the compound towards cloned human Dopamine receptor D2A using [3H]- Raclopride as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50096740((R)-7-Methyl-6a,7,8,9-tetrahydro-6H-2-oxa-7-aza-be...)
Affinity DataKi:  283nMAssay Description:In vitro binding affinity of the compound towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]-5-HT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM29644((6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataKi:  296nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 variant with Y181C plus K103N mutatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50096741((R)-7-Methyl-6a,7,8,9-tetrahydro-6H-1,7-diaza-benz...)
Affinity DataKi:  327nMAssay Description:In vitro binding affinity of the compound towards cloned human Dopamine receptor D2A using [3H]- Raclopride as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50202298((R)-7-Methyl-1,6,6a,7,8,9-hexahydro-1,7-diaza-benz...)
Affinity DataKi:  341nMAssay Description:In vitro binding affinity of the compound towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]-5-HT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50202298((R)-7-Methyl-1,6,6a,7,8,9-hexahydro-1,7-diaza-benz...)
Affinity DataKi:  373nMAssay Description:In vitro binding affinity of the compound towards cloned human 5-hydroxytryptamine 1A receptor expressed in Chinese hamster ovary (CHO) cells using [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50096740((R)-7-Methyl-6a,7,8,9-tetrahydro-6H-2-oxa-7-aza-be...)
Affinity DataKi:  541nMAssay Description:In vitro binding affinity of the compound towards cloned human Dopamine receptor D2A using [3H]- Raclopride as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50096740((R)-7-Methyl-6a,7,8,9-tetrahydro-6H-2-oxa-7-aza-be...)
Affinity DataKi:  1.15E+3nMAssay Description:In vitro binding affinity of the compound towards 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in rat hippocampus membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50096742((R)-7-Methyl-6a,7,8,9-tetrahydro-6H-2,7-diaza-benz...)
Affinity DataKi:  1.33E+3nMAssay Description:In vitro binding affinity of the compound towards cloned human Dopamine receptor D2A using [3H]- Raclopride as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50096739((R)-7-methyl-6a,7,8,9-tetrahydro-6H-1-oxa-7-aza-be...)
Affinity DataKi:  1.48E+3nMAssay Description:In vitro binding affinity of the compound towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]-5-HT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50096739((R)-7-methyl-6a,7,8,9-tetrahydro-6H-1-oxa-7-aza-be...)
Affinity DataKi:  2.03E+3nMAssay Description:In vitro binding affinity of the compound towards 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in rat hippocampus membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50202298((R)-7-Methyl-1,6,6a,7,8,9-hexahydro-1,7-diaza-benz...)
Affinity DataKi:  6.11E+3nMAssay Description:In vitro binding affinity of the compound towards cloned human Dopamine receptor D2A using [3H]- Raclopride as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed