Compile Data Set for Download or QSAR
maximum 50k data
Found 76 Enz. Inhib. hit(s) with all data for entry = 50012536
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120247(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  8.5nMAssay Description:Concentration of the compound required to inhibit human recombinant Poly (ADP-ribose) polymerase 1 was determined using doseresponse inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120236(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120246(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120257(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120269(CHEMBL322133 | N-[2-(4-Bromo-phenyl)-2-oxo-ethyl]-...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120237(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120262(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  20nMAssay Description:Concentration required to inhibit human recombinant PARP-1 was determined using cell protection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120244(CHEMBL108341 | N-(2-Biphenyl-4-yl-2-oxo-ethyl)-3-(...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120262(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  20nMAssay Description:Concentration required to inhibit human recombinant PARP-1 was determined using cell protection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120251(CHEMBL108702 | N-[2-(3'-Amino-biphenyl-4-yl)-2-oxo...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120267(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120261(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120239(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  20nMAssay Description:Concentration required to inhibit human recombinant PARP-1 was determined using cell protection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120242(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120274(3-(2,4-Dioxo-3,4,5,6,7,8-hexahydro-2H-quinazolin-1...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120254(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120265(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120277(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120256(CHEMBL110115 | N-[2-(4-Difluoromethoxy-phenyl)-2-o...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120238(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  30nMAssay Description:Concentration required to inhibit human recombinant PARP-1 was determined using cell protection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120253(Benzoic acid 4-{2-[3-(2,4-dioxo-3,4,7,8-tetrahydro...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120241(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  35nMAssay Description:Concentration required to inhibit human recombinant PARP-1 was determined using cell protection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120272(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120249(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120266(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  50nMAssay Description:Concentration required to inhibit human recombinant PARP-1 was determined using cell protection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120273(2-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  60nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120260(CHEMBL111606 | N-[2-(4-Chloro-phenyl)-2-oxo-ethyl]...)
Affinity DataIC50:  60nMAssay Description:Concentration required to inhibit human recombinant PARP-1 was determined using cell protection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120252(CHEMBL322957 | N-[2-(3-Bromo-phenyl)-2-oxo-ethyl]-...)
Affinity DataIC50:  70nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120235(CHEMBL107616 | N-(2-Biphenyl-3-yl-2-oxo-ethyl)-3-(...)
Affinity DataIC50:  70nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120240(CHEMBL410733 | N-{2-[4-(3-Amino-pyridin-2-yl)-pipe...)
Affinity DataIC50:  70nMAssay Description:Concentration required to inhibit human recombinant PARP-1 was determined using cell protection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120268(CHEMBL421605 | N-[2-(4-Bromo-phenyl)-2-oxo-ethyl]-...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120278(3-(2,4-Dioxo-3,4,5,6,7,8-hexahydro-2H-quinazolin-1...)
Affinity DataIC50:  90nMAssay Description:Concentration required to inhibit human recombinant PARP-1 was determined using cell protection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120255(2-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120243(3-(2,4-Dioxo-3,4,5,6,7,8-hexahydro-2H-quinazolin-1...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120263(6-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  250nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120275(3-(2,4-Dioxo-3,4,5,6,7,8-hexahydro-2H-quinazolin-1...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120264(3-(2,4-Dioxo-3,4,5,6,7,8-hexahydro-2H-quinazolin-1...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120245(3-(2,4-Dioxo-3,4,5,6,7,8-hexahydro-2H-quinazolin-1...)
Affinity DataIC50:  450nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120271(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-pyrano[4,3-d...)
Affinity DataIC50:  800nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120248(3-(2,4-Dioxo-2,3,4,5,6,7,8,9-octahydro-cycloheptap...)
Affinity DataIC50:  900nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120259(3-(2,4-Dioxo-2,3,4,5,8,9-hexahydro-cycloheptapyrim...)
Affinity DataIC50:  900nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120250(1-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-5,6,...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120258(3-(2,4-Dioxo-2,3,4,5,6,7-hexahydro-cyclopentapyrim...)
Affinity DataIC50:  3.00E+3nMAssay Description:Concentration of the compound required to inhibit human recombinant Poly (ADP-ribose) polymerase 1 was determined using doseresponse inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120270(3-(2,4-Dioxo-2,3,4,5,10,11-hexahydro-cyclononapyri...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120276(3-(2,4-Dioxo-3,4,5,6,7,8-hexahydro-2H-quinazolin-1...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibitory activity against human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120237(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataEC50:  100nMAssay Description:Concentration required to inhibit human recombinant PARP-1 was determined using cell protection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120241(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataEC50:  100nMAssay Description:Concentration required to inhibit human recombinant PARP-1 was determined using cell protection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120246(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataEC50:  100nMAssay Description:Concentration required to inhibit human recombinant PARP-1 was determined using cell protection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120260(CHEMBL111606 | N-[2-(4-Chloro-phenyl)-2-oxo-ethyl]...)
Affinity DataEC50:  500nMAssay Description:Concentration required to inhibit human recombinant PARP-1 was determined using cell protection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50120251(CHEMBL108702 | N-[2-(3'-Amino-biphenyl-4-yl)-2-oxo...)
Affinity DataEC50:  70nMAssay Description:Concentration required to inhibit human recombinant PARP-1 was determined using cell protection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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