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Found 112 Enz. Inhib. hit(s) with all data for entry = 50037288
TargetEndothelin-1 receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50140757(BMS-207940 | CHEMBL277447 | N-[2'-(3,4-Dimethyl-is...)
Affinity DataKi:  0.0100nMAssay Description:Inhibitory concentration against Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50133923(4-Cyano-1-methoxy-naphthalene-2-carboxylic acid (1...)
Affinity DataKi:  0.110nMAssay Description:Binding affinity against Dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  0.160nMAssay Description:Binding affinity towards human serotonin 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  0.160nMAssay Description:Binding affinity towards recombinant human alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50048803(5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)et...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity towards human serotonin 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50140762(4-((S)-3,4-Difluoro-phenyl)-2-methoxymethyl-6-oxo-...)
Affinity DataKi:  0.360nMAssay Description:Binding affinity towards recombinant human alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50001786(1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl...)
Affinity DataKi:  0.850nMAssay Description:Binding affinity towards human serotonin 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM35255(2-Chlor-11-(2-dimethylaminoaethoxy)-dibenzo(b,f)-t...)
Affinity DataKi:  0.910nMAssay Description:Binding affinity towards human serotonin 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50001786(1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity towards human serotonin 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetEndothelin-1 receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50091105(4''-Oxazol-2-yl-biphenyl-2-sulfonic acid (3,4-dime...)
Affinity DataKi:  1.40nMAssay Description:Inhibitory concentration against Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity towards human Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50001786(1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of currents elicited by GABA at EC5 (6-12 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity towards human serotonin 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50140755(CHEMBL428705 | N-(1-Benzyl-pyrrolidin-3-yl)-5-chlo...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity towards human Dopamine receptor D4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity towards human histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  2.30nMAssay Description:In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistamine H1 receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity towards human histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM35255(2-Chlor-11-(2-dimethylaminoaethoxy)-dibenzo(b,f)-t...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity towards human serotonin 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50140751(2-{6-[2-(8-Aza-bicyclo[3.2.1]oct-8-yl)-ethylamino]...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity towards human Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity towards human serotonin 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM35255(2-Chlor-11-(2-dimethylaminoaethoxy)-dibenzo(b,f)-t...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity towards human alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM35255(2-Chlor-11-(2-dimethylaminoaethoxy)-dibenzo(b,f)-t...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity towards human histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  3.5nMAssay Description:Binding affinity towards human histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  4.60nMAssay Description:Invitro evaluation against RXR-alpha in CV-1 cells by cotransfection assay was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50048803(5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)et...)
Affinity DataKi:  5.30nMAssay Description:Binding affinity towards human histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(1B) dopamine receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50140768(5-Chloro-4-(cyclopropanecarbonyl-amino)-2-methoxy-...)
Affinity DataKi:  5.60nMAssay Description:Binding affinity against human Dopamine receptor D4 versus hD2, hD3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50050794(2-(4,6-Dimethoxy-pyrimidin-2-yloxy)-3-methoxy-3,3-...)
Affinity DataKi:  6nMAssay Description:Binding affinity against human Endothelin A receptor; orally active in vivo at 30 mg/kg, poMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  7.10nMAssay Description:Binding affinity towards human serotonin 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(2) dopamine receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50001786(1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl...)
Affinity DataKi:  7.40nMAssay Description:Binding affinity towards human Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(3) dopamine receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50048803(5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)et...)
Affinity DataKi:  7.5nMAssay Description:Binding affinity towards human Dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  7.5nMAssay Description:Binding affinity towards human alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(3) dopamine receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50001786(1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl...)
Affinity DataKi:  8.20nMAssay Description:Binding affinity towards human Dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50048803(5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)et...)
Affinity DataKi:  9.70nMAssay Description:Binding affinity towards human Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(4) dopamine receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  11nMAssay Description:Binding affinity towards human dopamine-4.2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50048803(5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)et...)
Affinity DataKi:  12nMAssay Description:Invitro evaluation against RXR-alpha in CV-1 cells by cotransfection assay was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50048803(5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)et...)
Affinity DataKi:  13nMAssay Description:Binding affinity towards human serotonin 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(3) dopamine receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  13nMAssay Description:Binding affinity towards human Dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  13nMAssay Description:Binding affinity towards human serotonin 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(2) dopamine receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM35255(2-Chlor-11-(2-dimethylaminoaethoxy)-dibenzo(b,f)-t...)
Affinity DataKi:  13nMAssay Description:Binding affinity towards human Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  16nMAssay Description:Binding affinity towards human dopamine-4.2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(3) dopamine receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM35255(2-Chlor-11-(2-dimethylaminoaethoxy)-dibenzo(b,f)-t...)
Affinity DataKi:  16nMAssay Description:Binding affinity towards human Dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  17nMAssay Description:Binding affinity towards human Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistamine H1 receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50095890(2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperaz...)
Affinity DataKi:  19nMAssay Description:Binding affinity towards human histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  19nMAssay Description:Binding affinity towards human alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50140755(CHEMBL428705 | N-(1-Benzyl-pyrrolidin-3-yl)-5-chlo...)
Affinity DataKi:  21nMAssay Description:Binding affinity against Dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  21nMAssay Description:Binding affinity towards human Dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50001786(1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl...)
Affinity DataKi:  21nMAssay Description:Binding affinity towards human dopamine-4.2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  23nMAssay Description:Inhibition of currents when compound wascoapplied with acetylcholine to recombinant Torpedo nAcChoR (from 6 oocytes)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  25nMAssay Description:Binding affinity towards human serotonin 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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