Compile Data Set for Download or QSAR
maximum 50k data
Found 25 Enz. Inhib. hit(s) with all data for entry = 50017150
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178273(CHEMBL202775 | N-((2-(2-cyclopropoxy-5-(trifluorom...)
Affinity DataKi:  190nMAssay Description:Displacement of [35S]-labelled MK499 from cloned hERG potassium channel expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178267(CHEMBL201362 | N-(2-methoxy-5-(trifluoromethoxy)be...)
Affinity DataKi:  240nMAssay Description:Displacement of [35S]-labelled MK499 from cloned hERG potassium channel expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178271((2-(2-cyclopropoxy-5-(trifluoromethoxy)benzylamino...)
Affinity DataKi:  270nMAssay Description:Displacement of [35S]-labelled MK499 from cloned hERG potassium channel expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178270(CHEMBL382803 | N-(2-cyclopropoxy-5-(trifluorometho...)
Affinity DataKi:  360nMAssay Description:Displacement of [35S]-labelled MK499 from cloned hERG potassium channel expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178269(CHEMBL382848 | N-((2-(2-cyclopropoxy-5-(trifluorom...)
Affinity DataKi:  420nMAssay Description:Displacement of [35S]-labelled MK499 from cloned hERG potassium channel expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178274(CHEMBL202141 | N-(2-chloro-5-(trifluoromethoxy)ben...)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of [35S]-labelled MK499 from cloned hERG potassium channel expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067935((2-Methoxy-5-trifluoromethoxy-benzyl)-((2S,3S)-2-p...)
Affinity DataKi:  1.80E+3nMAssay Description:Displacement of [35S]-labelled MK499 from cloned hERG potassium channel expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178266(2-(2-cyclopropoxy-5-(trifluoromethoxy)benzylamino)...)
Affinity DataKi:  4.80E+3nMAssay Description:Displacement of [35S]-labelled MK499 from cloned hERG potassium channel expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178268(2-(2-cyclopropoxy-5-(trifluoromethoxy)benzylamino)...)
Affinity DataKi: >5.00E+3nMAssay Description:Displacement of [35S]-labelled MK499 from cloned hERG potassium channel expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178276(5-(2-(2-cyclopropoxy-5-(trifluoromethoxy)benzylami...)
Affinity DataKi:  5.80E+3nMAssay Description:Displacement of [35S]-labelled MK499 from cloned hERG potassium channel expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178265(2-(2-cyclopropoxy-5-(trifluoromethoxy)benzylamino)...)
Affinity DataKi: >6.00E+3nMAssay Description:Displacement of [35S]-labelled MK499 from cloned hERG potassium channel expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178272(CHEMBL201192 | N-(2-cyclopropoxy-5-(trifluorometho...)
Affinity DataKi: >6.00E+3nMAssay Description:Displacement of [35S]-labelled MK499 from cloned hERG potassium channel expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178269(CHEMBL382848 | N-((2-(2-cyclopropoxy-5-(trifluorom...)
Affinity DataIC50:  0.0900nMAssay Description:Displacement of [125I]-labelled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178270(CHEMBL382803 | N-(2-cyclopropoxy-5-(trifluorometho...)
Affinity DataIC50:  0.100nMAssay Description:Displacement of [125I]-labelled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178271((2-(2-cyclopropoxy-5-(trifluoromethoxy)benzylamino...)
Affinity DataIC50:  0.110nMAssay Description:Displacement of [125I]-labelled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178267(CHEMBL201362 | N-(2-methoxy-5-(trifluoromethoxy)be...)
Affinity DataIC50:  0.130nMAssay Description:Displacement of [125I]-labelled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067935((2-Methoxy-5-trifluoromethoxy-benzyl)-((2S,3S)-2-p...)
Affinity DataIC50:  0.140nMAssay Description:Displacement of [125I]-labelled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178273(CHEMBL202775 | N-((2-(2-cyclopropoxy-5-(trifluorom...)
Affinity DataIC50:  0.240nMAssay Description:Displacement of [125I]-labelled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178265(2-(2-cyclopropoxy-5-(trifluoromethoxy)benzylamino)...)
Affinity DataIC50:  0.270nMAssay Description:Displacement of [125I]-labelled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178276(5-(2-(2-cyclopropoxy-5-(trifluoromethoxy)benzylami...)
Affinity DataIC50:  0.610nMAssay Description:Displacement of [125I]-labelled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178272(CHEMBL201192 | N-(2-cyclopropoxy-5-(trifluorometho...)
Affinity DataIC50:  0.650nMAssay Description:Displacement of [125I]-labelled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178266(2-(2-cyclopropoxy-5-(trifluoromethoxy)benzylamino)...)
Affinity DataIC50:  1nMAssay Description:Displacement of [125I]-labelled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178268(2-(2-cyclopropoxy-5-(trifluoromethoxy)benzylamino)...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [125I]-labelled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178274(CHEMBL202141 | N-(2-chloro-5-(trifluoromethoxy)ben...)
Affinity DataIC50:  2.10nMAssay Description:Displacement of [125I]-labelled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178275(CHEMBL370816 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataIC50:  3nMAssay Description:Displacement of [125I]-labelled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed