Compile Data Set for Download or QSAR
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Found 24 Enz. Inhib. hit(s) with all data for entry = 50017257
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179771(3-(3,5-bis-trifluoromethyl-phenyl)-1-[4-(2-oxa-8-a...)
Affinity DataKi:  327nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179768(3-(3,5-bis-trifluoromethyl-phenyl)-3-methyl-1-[4-(...)
Affinity DataKi:  364nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179773(2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(2-oxa-8-a...)
Affinity DataKi:  787nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179772(3-(3,5-bis-trifluoromethyl-phenyl)-1-[4-(2-oxa-8-a...)
Affinity DataKi:  798nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179770(3-(3,5-bis-trifluoromethyl-phenyl)-3-hydroxy-1-[4-...)
Affinity DataKi:  862nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179769(3-(3,5-bis-trifluoromethyl-phenyl)-3-methoxy-1-[4-...)
Affinity DataKi:  947nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179777(3-(3,5-bis(trifluoromethyl)phenyl)-1-((1r,4r)-4-(d...)
Affinity DataKi:  984nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179778(4-((1r,4r)-4-(3-(3,5-bis(trifluoromethyl)phenyl)-3...)
Affinity DataKi:  1.95E+3nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179774(4-((1r,4r)-4-(3-(3,5-bis(trifluoromethyl)phenyl)-2...)
Affinity DataKi:  2.00E+3nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179775(4-((1r,4r)-4-(3-(3,5-bis(trifluoromethyl)phenyl)-3...)
Affinity DataKi:  2.99E+3nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179779(2-(3,5-bis(trifluoromethyl)phenyl)-N-((1r,4r)-4-(3...)
Affinity DataKi:  3.71E+3nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179776(4-((1r,4r)-4-(3-(3,5-bis(trifluoromethyl)phenyl)-2...)
Affinity DataKi:  6.53E+3nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179768(3-(3,5-bis-trifluoromethyl-phenyl)-3-methyl-1-[4-(...)
Affinity DataIC50:  0.330nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179773(2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(2-oxa-8-a...)
Affinity DataIC50:  0.340nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179775(4-((1r,4r)-4-(3-(3,5-bis(trifluoromethyl)phenyl)-3...)
Affinity DataIC50:  0.480nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179769(3-(3,5-bis-trifluoromethyl-phenyl)-3-methoxy-1-[4-...)
Affinity DataIC50:  0.480nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179778(4-((1r,4r)-4-(3-(3,5-bis(trifluoromethyl)phenyl)-3...)
Affinity DataIC50:  0.480nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179771(3-(3,5-bis-trifluoromethyl-phenyl)-1-[4-(2-oxa-8-a...)
Affinity DataIC50:  0.5nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179779(2-(3,5-bis(trifluoromethyl)phenyl)-N-((1r,4r)-4-(3...)
Affinity DataIC50:  0.620nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179770(3-(3,5-bis-trifluoromethyl-phenyl)-3-hydroxy-1-[4-...)
Affinity DataIC50:  0.660nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179772(3-(3,5-bis-trifluoromethyl-phenyl)-1-[4-(2-oxa-8-a...)
Affinity DataIC50:  0.800nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179774(4-((1r,4r)-4-(3-(3,5-bis(trifluoromethyl)phenyl)-2...)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179776(4-((1r,4r)-4-(3-(3,5-bis(trifluoromethyl)phenyl)-2...)
Affinity DataIC50:  1.5nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179777(3-(3,5-bis(trifluoromethyl)phenyl)-1-((1r,4r)-4-(d...)
Affinity DataIC50:  6.20nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed