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Found 16 Enz. Inhib. hit(s) with all data for entry = 2455
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Conforma Therapeutics

LigandPNGBDBM15374(9-butyl-8-(3,4,5-trimethoxybenzyl)-9H-purin-6-amin...)
Affinity DataEC50:  4.00E+4nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Conforma Therapeutics

LigandPNGBDBM20753(9-{2-[(2,2-dimethylpropyl)amino]ethyl}-8-[(2-iodo-...)
Affinity DataEC50:  90nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Conforma Therapeutics

LigandPNGBDBM20741(8-benzyladenine analogue, 12b | 9-butyl-8-[(2-chlo...)
Affinity DataEC50:  2.00E+4nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Conforma Therapeutics

LigandPNGBDBM20742(8-[(2-bromo-5-methoxyphenyl)methyl]-9-butyl-9H-pur...)
Affinity DataEC50:  8.00E+3nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Conforma Therapeutics

LigandPNGBDBM20743(8-benzyladenine analogue, 12d | 9-butyl-8-[(2-iodo...)
Affinity DataEC50:  5.00E+3nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Conforma Therapeutics

LigandPNGBDBM20744(8-sulfanyladenine analogue, 18 | 9-butyl-8-[(2,5-d...)
Affinity DataEC50:  3.50E+3nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Conforma Therapeutics

LigandPNGBDBM20745(8-Sulfanyladenine | 8-[(2-iodo-5-methoxyphenyl)sul...)
Affinity DataEC50:  280nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Conforma Therapeutics

LigandPNGBDBM20746(8-[(2-iodo-5-methoxyphenyl)sulfanyl]-9-(4-methylpe...)
Affinity DataEC50:  370nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Conforma Therapeutics

LigandPNGBDBM20747(2-fluoro-8-[(2-iodo-5-methoxyphenyl)sulfanyl]-9-(p...)
Affinity DataEC50:  360nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Conforma Therapeutics

LigandPNGBDBM15381(8-(2-chloro-3,4,5-trimethoxybenzyl)-2-fluoro-9-pen...)
Affinity DataEC50:  1.70E+3nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Conforma Therapeutics

LigandPNGBDBM20748(8-[(2-iodo-5-methoxyphenyl)sulfanyl]-9-[3-(pentan-...)
Affinity DataEC50:  210nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Conforma Therapeutics

LigandPNGBDBM20749(9-[3-(butan-2-ylamino)propyl]-8-[(2-iodo-5-methoxy...)
Affinity DataEC50:  210nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Conforma Therapeutics

LigandPNGBDBM20750(8-[(2-iodo-5-methoxyphenyl)sulfanyl]-9-[3-(propan-...)
Affinity DataEC50:  180nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Conforma Therapeutics

LigandPNGBDBM20751(9-[3-(tert-butylamino)propyl]-8-[(2-iodo-5-methoxy...)
Affinity DataEC50:  140nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Conforma Therapeutics

LigandPNGBDBM20752(8-[(2-iodo-5-methoxyphenyl)sulfanyl]-9-{2-[(2-meth...)
Affinity DataEC50:  100nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Conforma Therapeutics

LigandPNGBDBM15378(9-butyl-8-(2,5-dimethoxybenzyl)-9H-purin-6-amine |...)
Affinity DataEC50:  1.20E+4nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair