Compile Data Set for Download or QSAR
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Found 38 Enz. Inhib. hit(s) with all data for entry = 50017483
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182718(4-(4-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-5-methy...)
Affinity DataIC50:  148nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM20882(4-[4-(4-benzylpiperazin-1-yl)-1H-pyrazol-3-yl]-6-c...)
Affinity DataIC50:  600nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182707(4-(4-(4-(4-(methylsulfonyl)benzyl)piperazin-1-yl)-...)
Affinity DataIC50:  600nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182712(4-(4-(4-(4-(methylsulfonyl)benzyl)piperazin-1-yl)-...)
Affinity DataIC50:  740nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182712(4-(4-(4-(4-(methylsulfonyl)benzyl)piperazin-1-yl)-...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182715(4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZE...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182700(4-phenethyl-6-(4-(piperazin-1-yl)-1H-pyrazol-3-yl)...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM20882(4-[4-(4-benzylpiperazin-1-yl)-1H-pyrazol-3-yl]-6-c...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182702(4-chloro-6-(5-methyl-4-(piperazin-1-yl)-1H-pyrazol...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182707(4-(4-(4-(4-(methylsulfonyl)benzyl)piperazin-1-yl)-...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182705(4-chloro-6-(4-(4-ethylpiperazin-1-yl)-1H-pyrazol-3...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182710(4-chloro-6-(4-(4-phenethylpiperazin-1-yl)-1H-pyraz...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182709(4-(4-(4-(4-(methylsulfonyl)benzyl)piperazin-1-yl)-...)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182703(4-bromo-6-(4-(4-(ethylamino)piperidin-1-yl)-1H-pyr...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182714(3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(pipera...)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182718(4-(4-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-5-methy...)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182715(4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZE...)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182716(5-(4-Piperazin-1-yl-1H-pyrazol-3-yl)-biphenyl-2,4-...)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182717(4-chloro-6-(4-(4-methylpiperazin-1-yl)-1H-pyrazol-...)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182714(3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(pipera...)
Affinity DataIC50:  9.50E+3nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182700(4-phenethyl-6-(4-(piperazin-1-yl)-1H-pyrazol-3-yl)...)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182716(5-(4-Piperazin-1-yl-1H-pyrazol-3-yl)-biphenyl-2,4-...)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182711(4-bromo-6-(4-(piperazin-1-yl)-1H-pyrazol-3-yl)benz...)
Affinity DataIC50:  9.70E+3nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182705(4-chloro-6-(4-(4-ethylpiperazin-1-yl)-1H-pyrazol-3...)
Affinity DataIC50:  1.17E+4nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182713(4-(4-(4-(4-(methylsulfonyl)benzylamino)piperidin-1...)
Affinity DataIC50:  1.39E+4nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182710(4-chloro-6-(4-(4-phenethylpiperazin-1-yl)-1H-pyraz...)
Affinity DataIC50:  1.55E+4nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182719(4-bromo-6-(4-(4-hydroxypiperidin-1-yl)-1H-pyrazol-...)
Affinity DataIC50:  2.12E+4nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182699(4-chloro-6-(4-morpholino-1H-pyrazol-3-yl)benzene-1...)
Affinity DataIC50:  2.17E+4nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182706(4-chloro-6-(5-(hydroxymethyl)-4-(piperazin-1-yl)-1...)
Affinity DataIC50:  2.51E+4nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182703(4-bromo-6-(4-(4-(ethylamino)piperidin-1-yl)-1H-pyr...)
Affinity DataIC50:  2.61E+4nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182702(4-chloro-6-(5-methyl-4-(piperazin-1-yl)-1H-pyrazol...)
Affinity DataIC50:  2.83E+4nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182709(4-(4-(4-(4-(methylsulfonyl)benzyl)piperazin-1-yl)-...)
Affinity DataIC50:  3.18E+4nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182701(2-(4-(3-(5-chloro-2,4-dihydroxyphenyl)-1H-pyrazol-...)
Affinity DataIC50:  3.26E+4nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182713(4-(4-(4-(4-(methylsulfonyl)benzylamino)piperidin-1...)
Affinity DataIC50:  4.03E+4nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182699(4-chloro-6-(4-morpholino-1H-pyrazol-3-yl)benzene-1...)
Affinity DataIC50:  6.87E+4nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182719(4-bromo-6-(4-(4-hydroxypiperidin-1-yl)-1H-pyrazol-...)
Affinity DataIC50:  9.69E+4nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182701(2-(4-(3-(5-chloro-2,4-dihydroxyphenyl)-1H-pyrazol-...)
Affinity DataIC50:  1.01E+5nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182706(4-chloro-6-(5-(hydroxymethyl)-4-(piperazin-1-yl)-1...)
Affinity DataIC50:  1.22E+5nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed