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Found 116 Enz. Inhib. hit(s) with all data for entry = 50017726
TargetNociceptin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185799(1-(1,2-dihydroacenaphthylen-1-yl)-4-(1-methyl-1H-p...)
Affinity DataKi:  2nMAssay Description:Agonist activity at ORL1 receptor expressed in HEK293 cells by calciun flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185800(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl...)
Affinity DataKi:  4nMAssay Description:Agonist activity at ORL1 receptor expressed in HEK293 cells by calciun flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185796(5-chloro-3-(1-(1,2-dihydroacenaphthylen-1-yl)piper...)
Affinity DataKi:  10nMAssay Description:Agonist activity at ORL1 receptor expressed in HEK293 cells by calciun flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185805(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl...)
Affinity DataKi:  18nMAssay Description:Displacement of [125I]Tyr14-nociceptin from ORL1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185813(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl...)
Affinity DataKi:  52nMAssay Description:Agonist activity at ORL1 receptor expressed in HEK293 cells by calciun flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185811(7-chloro-3-(1-(1,2-dihydroacenaphthylen-1-yl)piper...)
Affinity DataKi:  57nMAssay Description:Displacement of [125I]Tyr14-nociceptin from ORL1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185788((2R)-1-(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperi...)
Affinity DataKi:  62nMAssay Description:Agonist activity at ORL1 receptor expressed in HEK293 cells by calciun flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185803(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl...)
Affinity DataKi:  81nMAssay Description:Agonist activity at ORL1 receptor expressed in HEK293 cells by calciun flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185812(2-(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4...)
Affinity DataKi:  94nMAssay Description:Agonist activity at ORL1 receptor expressed in HEK293 cells by calciun flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185786(3-(1-(1,2-dihydroacenaphthylen-1-yl)-1,2,3,6-tetra...)
Affinity DataKi:  160nMAssay Description:Agonist activity at ORL1 receptor expressed in HEK293 cells by calciun flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185799(1-(1,2-dihydroacenaphthylen-1-yl)-4-(1-methyl-1H-p...)
Affinity DataKi:  170nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185810(3-(1-(cyclooctylmethyl)piperidin-4-yl)-5-fluoro-1H...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185792(3-(1-benzylpiperidin-4-yl)-5-chloro-1H-indole | CH...)
Affinity DataKi:  230nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185811(7-chloro-3-(1-(1,2-dihydroacenaphthylen-1-yl)piper...)
Affinity DataKi:  260nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185796(5-chloro-3-(1-(1,2-dihydroacenaphthylen-1-yl)piper...)
Affinity DataKi:  260nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185810(3-(1-(cyclooctylmethyl)piperidin-4-yl)-5-fluoro-1H...)
Affinity DataKi:  290nMAssay Description:Agonist activity at ORL1 receptor expressed in HEK293 cells by calciun flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185807(5-chloro-3-(1-(cyclooctylmethyl)piperidin-4-yl)-2-...)
Affinity DataKi:  330nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185808(3-(1-(4-phenoxybenzyl)piperidin-4-yl)-1H-pyrrolo[2...)
Affinity DataKi:  330nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185792(3-(1-benzylpiperidin-4-yl)-5-chloro-1H-indole | CH...)
Affinity DataKi:  330nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185802(3-(1-(naphthalen-1-ylmethyl)piperidin-4-yl)-1H-pyr...)
Affinity DataKi:  340nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185800(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl...)
Affinity DataKi:  390nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185798(7-chloro-3-(1-(cyclooctylmethyl)piperidin-4-yl)-1H...)
Affinity DataKi:  430nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185809(3-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-5-chlo...)
Affinity DataKi:  500nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185794(5-fluoro-3-(1-(naphthalen-1-ylmethyl)piperidin-4-y...)
Affinity DataKi:  500nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185805(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl...)
Affinity DataKi:  500nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185812(2-(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4...)
Affinity DataKi:  530nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185806(3-(1-(cyclooctylmethyl)piperidin-4-yl)-1H-pyrrolo[...)
Affinity DataKi:  550nMAssay Description:Agonist activity at ORL1 receptor expressed in HEK293 cells by calciun flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185798(7-chloro-3-(1-(cyclooctylmethyl)piperidin-4-yl)-1H...)
Affinity DataKi:  660nMAssay Description:Agonist activity at ORL1 receptor expressed in HEK293 cells by calciun flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185796(5-chloro-3-(1-(1,2-dihydroacenaphthylen-1-yl)piper...)
Affinity DataKi:  680nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185802(3-(1-(naphthalen-1-ylmethyl)piperidin-4-yl)-1H-pyr...)
Affinity DataKi:  710nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185807(5-chloro-3-(1-(cyclooctylmethyl)piperidin-4-yl)-2-...)
Affinity DataKi:  710nMAssay Description:Agonist activity at ORL1 receptor expressed in HEK293 cells by calciun flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185795(5-chloro-2-methyl-3-(1-(naphthalen-1-ylmethyl)pipe...)
Affinity DataKi:  750nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185788((2R)-1-(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperi...)
Affinity DataKi:  760nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185794(5-fluoro-3-(1-(naphthalen-1-ylmethyl)piperidin-4-y...)
Affinity DataKi:  800nMAssay Description:Agonist activity at ORL1 receptor expressed in HEK293 cells by calciun flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185802(3-(1-(naphthalen-1-ylmethyl)piperidin-4-yl)-1H-pyr...)
Affinity DataKi:  820nMAssay Description:Agonist activity at ORL1 receptor expressed in HEK293 cells by calciun flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185794(5-fluoro-3-(1-(naphthalen-1-ylmethyl)piperidin-4-y...)
Affinity DataKi:  820nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185795(5-chloro-2-methyl-3-(1-(naphthalen-1-ylmethyl)pipe...)
Affinity DataKi:  880nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185813(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl...)
Affinity DataKi:  900nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185803(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl...)
Affinity DataKi:  900nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185789((R)-1-(3-(1-(cyclooctylmethyl)piperidin-4-yl)-5-fl...)
Affinity DataKi:  970nMAssay Description:Agonist activity at ORL1 receptor expressed in HEK293 cells by calciun flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185809(3-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-5-chlo...)
Affinity DataKi:  1.01E+3nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185810(3-(1-(cyclooctylmethyl)piperidin-4-yl)-5-fluoro-1H...)
Affinity DataKi:  1.08E+3nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185792(3-(1-benzylpiperidin-4-yl)-5-chloro-1H-indole | CH...)
Affinity DataKi:  1.14E+3nMAssay Description:Agonist activity at ORL1 receptor expressed in HEK293 cells by calciun flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185798(7-chloro-3-(1-(cyclooctylmethyl)piperidin-4-yl)-1H...)
Affinity DataKi:  1.17E+3nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185807(5-chloro-3-(1-(cyclooctylmethyl)piperidin-4-yl)-2-...)
Affinity DataKi:  1.36E+3nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185797(1-((R)-3-amino-2-hydroxypropyl)-3-(1-(1,2-dihydroa...)
Affinity DataKi:  1.65E+3nMAssay Description:Agonist activity at ORL1 receptor expressed in HEK293 cells by calciun flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185805(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl...)
Affinity DataKi:  1.89E+3nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185789((R)-1-(3-(1-(cyclooctylmethyl)piperidin-4-yl)-5-fl...)
Affinity DataKi:  1.90E+3nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185806(3-(1-(cyclooctylmethyl)piperidin-4-yl)-1H-pyrrolo[...)
Affinity DataKi:  2.00E+3nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50185811(7-chloro-3-(1-(1,2-dihydroacenaphthylen-1-yl)piper...)
Affinity DataKi:  2.60E+3nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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