Compile Data Set for Download or QSAR
maximum 50k data
Found 96 Enz. Inhib. hit(s) with all data for entry = 50018069
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190746((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)
Affinity DataIC50:  10.2nMAssay Description:Inhibition of rabbit NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190771((R)-2-((1-((2-(hydroxymethyl)-2,3-dihydro-1H-inden...)
Affinity DataIC50:  11nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190746((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)
Affinity DataIC50:  14.3nMAssay Description:Inhibition of rat NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190746((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)
Affinity DataIC50:  18.9nMAssay Description:Inhibition of human NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190746((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)
Affinity DataIC50:  19.7nMAssay Description:Inhibition of human recombinant NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190746((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)
Affinity DataIC50:  26nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190753(2-((1-((5-benzyl-1,3,4-thiadiazol-2-yl)carbamoyl)c...)
Affinity DataIC50:  30nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190762(2-((1-((5-(cyclopropylmethyl)-1,3,4-thiadiazol-2-y...)
Affinity DataIC50:  38nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190737(2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl)cy...)
Affinity DataIC50:  46nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190773(2-[1-(5-ethyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-cyc...)
Affinity DataIC50:  60nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190752(2-((1-((1-ethyl-1H-1,2,3-triazol-4-yl)carbamoyl)cy...)
Affinity DataIC50:  82nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190764(2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl)cy...)
Affinity DataIC50:  84nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190750(2-((1-((4-benzylpyridin-2-yl)carbamoyl)cyclopentyl...)
Affinity DataIC50:  96nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190769(CHEMBL377037 | rac-2-((1-((2-(hydroxymethyl)-2,3-d...)
Affinity DataIC50:  96nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190739((R)-2-((1-((5-methyl-1,3,4-thiadiazol-2-yl)carbamo...)
Affinity DataIC50:  114nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190738(2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl)cy...)
Affinity DataIC50:  120nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190758(2-((1-((5-isobutyl-1,3,4-thiadiazol-2-yl)carbamoyl...)
Affinity DataIC50:  124nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190757(CHEMBL439508 | cis-2-((1-((4-carbamoylcyclohexyl)c...)
Affinity DataIC50:  150nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190761(CHEMBL209493 | rac-2-((1-((5-methyl-1,3,4-thiadiaz...)
Affinity DataIC50:  176nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190780(2-((1-((4-butylpyridin-2-yl)carbamoyl)cyclopentyl)...)
Affinity DataIC50:  184nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190777(2-((1-(((1R,2R)-2-benzylcyclohexyl)carbamoyl)cyclo...)
Affinity DataIC50:  195nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190743((S)-2-((1-((2-(hydroxymethyl)-2,3-dihydro-1H-inden...)
Affinity DataIC50:  205nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190782(2-((1-(((1R,3S)-3-carbamoylcyclopentyl)carbamoyl)c...)
Affinity DataIC50:  213nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190763(3-(1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl)cyc...)
Affinity DataIC50:  237nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190775(2-((1-((5-phenyl-1,3,4-thiadiazol-2-yl)carbamoyl)c...)
Affinity DataIC50:  283nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190742((S)-2-((1-((5-methyl-1,3,4-thiadiazol-2-yl)carbamo...)
Affinity DataIC50:  286nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190736((S)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)
Affinity DataIC50:  292nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190767(2-((1-((3-(dimethylcarbamoyl)cyclohexyl)carbamoyl)...)
Affinity DataIC50:  297nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190755(2-((1-((2,3-dihydro-1H-inden-2-yl)carbamoyl)cyclop...)
Affinity DataIC50:  313nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190760(2-((1-((1-benzyl-6-oxo-1,6-dihydropyridin-3-yl)car...)
Affinity DataIC50:  313nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190772(CHEMBL213240 | cis-2-((1-((4-(dimethylcarbamoyl)cy...)
Affinity DataIC50:  370nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190766(2-((1-((6-methoxypyridazin-3-yl)carbamoyl)cyclopen...)
Affinity DataIC50:  374nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190774(2-((1-((1,3,4-thiadiazol-2-yl)carbamoyl)cyclopenty...)
Affinity DataIC50:  377nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190748(2-((1-(((S)-1-hydroxy-3-phenylpropan-2-yl)carbamoy...)
Affinity DataIC50:  384nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190770(2-((1-(((R)-1-phenylethyl)carbamoyl)cyclopentyl)me...)
Affinity DataIC50:  530nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190740(2-((1-(((5-methyl-1,3,4-thiadiazol-2-yl)methyl)car...)
Affinity DataIC50:  700nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190781(2-((1-(((1R,2S)-2-propylcyclohexyl)carbamoyl)cyclo...)
Affinity DataIC50:  890nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190759(2-((1-(((R)-1-benzylpyrrolidin-3-yl)carbamoyl)cycl...)
Affinity DataIC50:  1.06E+3nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190779(2-((1-(5-(1-benzyl-6-oxo-1,6-dihydropyridin-3-yl)-...)
Affinity DataIC50:  1.14E+3nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190741(2-((1-(pyridin-2-ylcarbamoyl)cyclopentyl)methyl)pe...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190765(2-((1-((benzo[d][1,3]dioxol-5-ylmethyl)carbamoyl)c...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190754(2-((1-((3-ethylpyridin-2-yl)carbamoyl)cyclopentyl)...)
Affinity DataIC50:  1.71E+3nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190749(2-((1-((1-(hydroxymethyl)cyclopentyl)carbamoyl)cyc...)
Affinity DataIC50:  1.71E+3nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190778(2-((1-((4-(propylamino)pyrimidin-2-yl)carbamoyl)cy...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190747(2-((1-((4-methylpyridin-2-yl)carbamoyl)cyclopentyl...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190756(2-((1-((4-chlorophenethyl)carbamoyl)cyclopentyl)me...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190768(2-((1-((6-ethylpyridin-2-yl)carbamoyl)cyclopentyl)...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190739((R)-2-((1-((5-methyl-1,3,4-thiadiazol-2-yl)carbamo...)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of dog ACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190740(2-((1-(((5-methyl-1,3,4-thiadiazol-2-yl)methyl)car...)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of dog ACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190741(2-((1-(pyridin-2-ylcarbamoyl)cyclopentyl)methyl)pe...)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of dog ACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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