Compile Data Set for Download or QSAR
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Found 28 Enz. Inhib. hit(s) with all data for entry = 50037761
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191139(2-(3-(3,4-dichlorophenoxy)prop-1-ynyl)-6-methylpyr...)
Affinity DataIC50:  15nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataIC50:  22nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191149(2-methyl-6-(3-(5,6,7,8-tetrahydronaphthalen-2-ylox...)
Affinity DataIC50:  36nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50122758(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Affinity DataIC50:  77nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191146(2-(3-(4-isopropylphenoxy)prop-1-ynyl)-6-methylpyri...)
Affinity DataIC50:  83nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191157(2-(3-(3-chlorophenoxy)prop-1-ynyl)-6-methylpyridin...)
Affinity DataIC50:  101nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191147(2-(3-(4-chlorophenoxy)prop-1-ynyl)-6-methylpyridin...)
Affinity DataIC50:  102nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191151(2-methyl-6-(3-(p-tolyloxy)prop-1-ynyl)pyridine | C...)
Affinity DataIC50:  115nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191148(2-(3-fluoro-5-(3-(pyridin-2-yl)prop-2-ynyloxy)phen...)
Affinity DataIC50:  300nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191142(2-(3-(3-methoxyphenoxy)prop-1-ynyl)-6-methylpyridi...)
Affinity DataIC50:  397nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191161(2-methyl-6-(3-(3-nitrophenoxy)prop-1-ynyl)pyridine...)
Affinity DataIC50:  416nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191145(2-(3-(4-methoxyphenoxy)prop-1-ynyl)-6-methylpyridi...)
Affinity DataIC50:  455nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191162(4-(3-(6-methylpyridin-2-yl)prop-2-ynyloxy)quinolin...)
Affinity DataIC50:  825nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191154(CHEMBL215702 | methyl 5-(3-(6-methylpyridin-2-yl)p...)
Affinity DataIC50:  1.49E+3nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191143(2-(3-(3-methoxyphenoxy)prop-1-ynyl)pyridine | CHEM...)
Affinity DataIC50:  1.54E+3nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191150(2-methyl-5-(3-(6-methylpyridin-2-yl)prop-2-ynyloxy...)
Affinity DataIC50:  2.49E+3nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191158(2-(3-(2-chlorophenoxy)prop-1-ynyl)-6-methylpyridin...)
Affinity DataIC50: >3.00E+3nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191156(2-(3-(3-methoxyphenoxy)prop-1-ynyl)-5-methylpyridi...)
Affinity DataIC50:  7.93E+3nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191144(2-methoxy-6-(3-(3-methoxyphenoxy)prop-1-ynyl)pyrid...)
Affinity DataIC50: >1.00E+4nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191152(4-(3-(3-methoxyphenoxy)prop-1-ynyl)pyridine | CHEM...)
Affinity DataIC50: >1.00E+4nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191160(2-(3-(3-methoxyphenoxy)prop-1-ynyl)-4-methylpyridi...)
Affinity DataIC50: >1.00E+4nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191141(2-methyl-6-(3-(pyridin-3-yloxy)prop-1-ynyl)pyridin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191142(2-(3-(3-methoxyphenoxy)prop-1-ynyl)-6-methylpyridi...)
Affinity DataIC50: >1.00E+4nMAssay Description:Activity at human mGluR1 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191140(2-methyl-6-(3-phenoxyprop-1-ynyl)pyridine | CHEMBL...)
Affinity DataIC50: >1.00E+4nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191159(2-(3-(3-methoxyphenoxy)prop-1-ynyl)-3-methylpyridi...)
Affinity DataIC50: >1.00E+4nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191153(2-(3-(3-methoxyphenoxy)prop-1-ynyl)pyrazine | CHEM...)
Affinity DataIC50: >1.00E+4nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191155(2-(3-(3-methoxyphenoxy)prop-1-ynyl)thiazole | CHEM...)
Affinity DataIC50: >1.00E+4nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50191143(2-(3-(3-methoxyphenoxy)prop-1-ynyl)pyridine | CHEM...)
Affinity DataIC50: >1.00E+4nMAssay Description:Activity at human mGluR1 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed