Compile Data Set for Download or QSAR
maximum 50k data
Found 150 Enz. Inhib. hit(s) with all data for entry = 50020580
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215321((3R,4R)-1-(2-oxo-2H-pyrimido[1,2-b]pyridazin-7-yl)...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215346((3R,4R)-1-(2-cyclopropyl-3-methyl-3H-imidazo[4,5-b...)
Affinity DataIC50:  2nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215350((3R,4R)-1-(2-methyl-3-oxo-2,3-dihydro-[1,2,4]triaz...)
Affinity DataIC50:  5nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215320((3R,4R)-1-(2-(trifluoromethyl)-[1,2,4]triazolo[1,5...)
Affinity DataIC50:  5nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215334((3R,4R)-1-(3-ethyl-[1,2,4]triazolo[4,3-b]pyridazin...)
Affinity DataIC50:  6nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215319((3R,4R)-1-(3-methyl-[1,2,4]triazolo[4,3-b]pyridazi...)
Affinity DataIC50:  6nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215336((3R,4R)-1-(2-methyl-4-oxo-3,4-dihydropyrido[3,2-d]...)
Affinity DataIC50:  7nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215345((3R,4R)-1-(pyrido[3,2-b]pyrazin-6-yl)-4-(2,4,5-tri...)
Affinity DataIC50:  7nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215335((3R,4R)-1-(2-methyl-4-oxo-4H-pyrimido[1,2-b]pyrida...)
Affinity DataIC50:  8nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215330((3R,4R)-1-(4-cyclopropylpyrido[3,2-d]pyrimidin-6-y...)
Affinity DataIC50:  8nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215351((3R,4R)-1-(3-(trifluoromethyl)-[1,2,4]triazolo[4,3...)
Affinity DataIC50:  9nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215323((3R,4R)-1-(quinoxalin-2-yl)-4-(2,4,5-trifluorophen...)
Affinity DataIC50:  12nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215333((3R,4R)-1-(pyrazino[2,3-b]pyrazin-2-yl)-4-(2,4,5-t...)
Affinity DataIC50:  13nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215343((3R,4R)-1-(5-cyanopyridin-2-yl)-4-(2,4,5-trifluoro...)
Affinity DataIC50:  14nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215328((3R,4R)-1-(3-(4-fluorophenyl)-[1,2,4]triazolo[4,3-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215326((3R,4R)-1-(2-(trifluoromethyl)imidazo[1,2-b]pyrida...)
Affinity DataIC50:  22nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215329((3R,4R)-1-([1,2,4]triazolo[4,3-a]pyrimidin-7-yl)-4...)
Affinity DataIC50:  26nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215332((3R,4R)-1-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4...)
Affinity DataIC50:  31nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215325((3R,4R)-1-(pyrimidin-4-yl)-4-(2,4,5-trifluoropheny...)
Affinity DataIC50:  37nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215347((3R,4R)-1-(pteridin-7-yl)-4-(2,4,5-trifluorophenyl...)
Affinity DataIC50:  43nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215342((3R,4R)-1-(quinolin-2-yl)-4-(2,4,5-trifluorophenyl...)
Affinity DataIC50:  54nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215324((3R,4R)-1-(pyridin-2-yl)-4-(2,4,5-trifluorophenyl)...)
Affinity DataIC50:  58nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215341((3R,4R)-1-(pyridazin-3-yl)-4-(2,4,5-trifluoropheny...)
Affinity DataIC50:  63nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215331((3R,4R)-1-(5-(trifluoromethyl)pyridin-2-yl)-4-(2,4...)
Affinity DataIC50:  67nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215340((3R,4R)-1-(pyrazin-2-yl)-4-(2,4,5-trifluorophenyl)...)
Affinity DataIC50:  82nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215349((3R,4R)-1-(pyrimidin-2-yl)-4-(2,4,5-trifluoropheny...)
Affinity DataIC50:  90nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215320((3R,4R)-1-(2-(trifluoromethyl)-[1,2,4]triazolo[1,5...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Cyp2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215352((3R,4R)-1-(6-(trifluoromethyl)pyridin-2-yl)-4-(2,4...)
Affinity DataIC50:  111nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215339((3R,4R)-1-(pyridin-4-yl)-4-(2,4,5-trifluorophenyl)...)
Affinity DataIC50:  125nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215327((3R,4R)-1-(pyrido[3,2-b]pyrazin-3-yl)-4-(2,4,5-tri...)
Affinity DataIC50:  130nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215337((3R,4R)-1-(pyridin-3-yl)-4-(2,4,5-trifluorophenyl)...)
Affinity DataIC50:  144nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215322((3R,4R)-1-phenyl-4-(2,4,5-trifluorophenyl)piperidi...)
Affinity DataIC50:  210nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215338((3R,4R)-1-(4-(trifluoromethyl)pyridin-2-yl)-4-(2,4...)
Affinity DataIC50:  463nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215348((3R,4R)-1-(3-(trifluoromethyl)pyridin-2-yl)-4-(2,4...)
Affinity DataIC50:  650nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215325((3R,4R)-1-(pyrimidin-4-yl)-4-(2,4,5-trifluoropheny...)
Affinity DataIC50:  950nMAssay Description:Inhibition of Cyp2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215344((3R,4R)-1-(isoquinolin-1-yl)-4-(2,4,5-trifluorophe...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215352((3R,4R)-1-(6-(trifluoromethyl)pyridin-2-yl)-4-(2,4...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of QPPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215322((3R,4R)-1-phenyl-4-(2,4,5-trifluorophenyl)piperidi...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of QPPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215343((3R,4R)-1-(5-cyanopyridin-2-yl)-4-(2,4,5-trifluoro...)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of DPP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215331((3R,4R)-1-(5-(trifluoromethyl)pyridin-2-yl)-4-(2,4...)
Affinity DataIC50:  7.60E+3nMAssay Description:Inhibition of DPP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215320((3R,4R)-1-(2-(trifluoromethyl)-[1,2,4]triazolo[1,5...)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of human ERG potassium channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215319((3R,4R)-1-(3-methyl-[1,2,4]triazolo[4,3-b]pyridazi...)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of Cyp2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215343((3R,4R)-1-(5-cyanopyridin-2-yl)-4-(2,4,5-trifluoro...)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of DPP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215333((3R,4R)-1-(pyrazino[2,3-b]pyrazin-2-yl)-4-(2,4,5-t...)
Affinity DataIC50:  9.90E+3nMAssay Description:Inhibition of human ERG potassium channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215330((3R,4R)-1-(4-cyclopropylpyrido[3,2-d]pyrimidin-6-y...)
Affinity DataIC50:  9.90E+3nMAssay Description:Inhibition of QPPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215342((3R,4R)-1-(quinolin-2-yl)-4-(2,4,5-trifluorophenyl...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of DPP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215323((3R,4R)-1-(quinoxalin-2-yl)-4-(2,4,5-trifluorophen...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of DPP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215333((3R,4R)-1-(pyrazino[2,3-b]pyrazin-2-yl)-4-(2,4,5-t...)
Affinity DataIC50:  1.16E+4nMAssay Description:Inhibition of Cyp2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215342((3R,4R)-1-(quinolin-2-yl)-4-(2,4,5-trifluorophenyl...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of DPP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50215331((3R,4R)-1-(5-(trifluoromethyl)pyridin-2-yl)-4-(2,4...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of DPP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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