Compile Data Set for Download or QSAR
maximum 50k data
Found 26 Enz. Inhib. hit(s) with all data for entry = 50027166
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264884(3-(2-chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-...)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of human alpha7 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264764(3-(2,6-dichlorophenyl)-5-(1-(piperidin-4-yl)-1H-py...)
Affinity DataEC50:  410nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264882(CHEMBL497990 | N-((3-(2-chlorophenyl)isoxazol-5-yl...)
Affinity DataEC50:  350nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264883(3-(2-chlorophenyl)-5-(1-(piperidin-4-yl)-1H-pyrazo...)
Affinity DataEC50:  120nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264884(3-(2-chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-...)
Affinity DataEC50:  18nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264914(3-phenyl-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)iso...)
Affinity DataEC50:  1.00E+5nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264915(5-(5-methyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)-3-...)
Affinity DataEC50:  1.20E+3nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264916(3-(2-chloro-6-fluorophenyl)-5-(1-(piperidin-4-yl)-...)
Affinity DataEC50:  48nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264917(3-(2-chloro-6-fluorophenyl)-5-(5-methyl-1-(piperid...)
Affinity DataEC50:  6nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264918(3-(2-chloro-5-fluorophenyl)-5-(1-(piperidin-4-yl)-...)
Affinity DataEC50:  270nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264919(3-(2-chloro-4-fluorophenyl)-5-(1-(piperidin-4-yl)-...)
Affinity DataEC50:  220nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264761(3-(2-chloro-3-fluorophenyl)-5-(1-(piperidin-4-yl)-...)
Affinity DataEC50:  230nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264765(3-methyl-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)iso...)
Affinity DataEC50:  1.30E+3nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264797(3-cyclohexyl-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl...)
Affinity DataEC50:  4.60E+3nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264798(3-(2-chlorophenyl)-5-(2-(piperidin-4-yl)thiazol-5-...)
Affinity DataEC50:  33nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264799(3-(2-chloro-6-fluorophenyl)-5-(1-methyl-2-(piperid...)
Affinity DataEC50:  12nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264800(3-(2-chloro-6-fluorophenyl)-5-(1-ethyl-2-(piperidi...)
Affinity DataEC50:  3nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264801(3-(2-chloro-6-fluorophenyl)-5-(2-(4-fluoropiperidi...)
Affinity DataEC50:  34nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264920(3-(2-chloro-6-fluorophenyl)-5-(1-ethyl-2-(4-fluoro...)
Affinity DataEC50:  3nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264882(CHEMBL497990 | N-((3-(2-chlorophenyl)isoxazol-5-yl...)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of human alpha3beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264883(3-(2-chlorophenyl)-5-(1-(piperidin-4-yl)-1H-pyrazo...)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of human alpha3beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264882(CHEMBL497990 | N-((3-(2-chlorophenyl)isoxazol-5-yl...)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of human alpha3beta4 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264883(3-(2-chlorophenyl)-5-(1-(piperidin-4-yl)-1H-pyrazo...)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of human alpha3beta4 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264762(3-(3-chloropyridin-4-yl)-5-(1-(piperidin-4-yl)-1H-...)
Affinity DataEC50:  200nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264763(3-(2-chlorothiophen-3-yl)-5-(1-(piperidin-4-yl)-1H...)
Affinity DataEC50:  130nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264884(3-(2-chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-...)
Affinity DataEC50:  20nMAssay Description:Activation of rat alpha4beta2 nAChR by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed