Compile Data Set for Download or QSAR
maximum 50k data
Found 55 Enz. Inhib. hit(s) with all data for entry = 50030358
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295066((2S)-8-Methyl-2-{[4-(6-nitroquinolin-2-yl)piperazi...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295064((2S)-2-{[4-(6-Chloroquinolin-2-yl)piperazin-1-yl]m...)
Affinity DataKi:  0.880nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM86708(CAS_146714-97-8 | CHEMBL31354 | CHEMBL514874 | CHE...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295055(2-(4-{[(2S)-8-Methyl-2,3-dihydro[1,4]dioxino[2,3-f...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295054((2S)-2-{[4-(6-Fluoroquinolin-2-yl)-1,4-diazepan-1-...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295055(2-(4-{[(2S)-8-Methyl-2,3-dihydro[1,4]dioxino[2,3-f...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295053((S)-2-((4-(1H-Indol-3-yl)-5,6-dihydropyridin-1(2H)...)
Affinity DataKi:  2.34nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295057(2-((3R)-3-Methyl-4-{[(2S)-8-methyl-2,3-dihydro[1,4...)
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295053((S)-2-((4-(1H-Indol-3-yl)-5,6-dihydropyridin-1(2H)...)
Affinity DataKi:  3.02nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295052(2-(4-{[(2S)-8-Methyl-2,3-dihydro[1,4]dioxino[2,3-f...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295054((2S)-2-{[4-(6-Fluoroquinolin-2-yl)-1,4-diazepan-1-...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295058((2S)-8-Methyl-2-{[(2R)-2-methyl-4-quinolin-2-ylpip...)
Affinity DataKi:  5.5nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295056((2S)-8-Methyl-2-[(4-quinolin-2-yl-1,4-diazepan-1-y...)
Affinity DataKi:  6.80nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295062(2-(4-{[(2S)-8-Methyl-2,3-dihydro[1,4]dioxino[2,3-f...)
Affinity DataKi:  7.20nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295056((2S)-8-Methyl-2-[(4-quinolin-2-yl-1,4-diazepan-1-y...)
Affinity DataKi:  7.40nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295059((2S)-8-Methyl-2-{[(2S)-2-methyl-4-quinolin-2-ylpip...)
Affinity DataKi:  10.3nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295063((2S)-2-{[4-(6-Bromoquinolin-2-yl)piperazin-1-yl]me...)
Affinity DataKi:  12.7nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295052(2-(4-{[(2S)-8-Methyl-2,3-dihydro[1,4]dioxino[2,3-f...)
Affinity DataKi:  13.8nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295062(2-(4-{[(2S)-8-Methyl-2,3-dihydro[1,4]dioxino[2,3-f...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295063((2S)-2-{[4-(6-Bromoquinolin-2-yl)piperazin-1-yl]me...)
Affinity DataKi:  17.2nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295066((2S)-8-Methyl-2-{[4-(6-nitroquinolin-2-yl)piperazi...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295058((2S)-8-Methyl-2-{[(2R)-2-methyl-4-quinolin-2-ylpip...)
Affinity DataKi:  32.8nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295065((2S)-2-{[4-(6-Fluoroquinolin-2-yl)piperazin-1-yl]m...)
Affinity DataKi:  32.9nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295060((2S)-8-Methyl-2-[(4-quinolin-2-ylpiperazin-1-yl)me...)
Affinity DataKi:  47.3nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295065((2S)-2-{[4-(6-Fluoroquinolin-2-yl)piperazin-1-yl]m...)
Affinity DataKi:  66nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295060((2S)-8-Methyl-2-[(4-quinolin-2-ylpiperazin-1-yl)me...)
Affinity DataKi:  75nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295057(2-((3R)-3-Methyl-4-{[(2S)-8-methyl-2,3-dihydro[1,4...)
Affinity DataKi:  89.6nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295061((2S)-8-Methyl-2-({4-[6-(trifluoromethoxy)quinolin-...)
Affinity DataKi:  149nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295059((2S)-8-Methyl-2-{[(2S)-2-methyl-4-quinolin-2-ylpip...)
Affinity DataKi:  167nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295061((2S)-8-Methyl-2-({4-[6-(trifluoromethoxy)quinolin-...)
Affinity DataKi:  172nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295064((2S)-2-{[4-(6-Chloroquinolin-2-yl)piperazin-1-yl]m...)
Affinity DataKi:  214nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295052(2-(4-{[(2S)-8-Methyl-2,3-dihydro[1,4]dioxino[2,3-f...)
Affinity DataKi:  1.31E+3nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295052(2-(4-{[(2S)-8-Methyl-2,3-dihydro[1,4]dioxino[2,3-f...)
Affinity DataKi:  1.32E+3nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295052(2-(4-{[(2S)-8-Methyl-2,3-dihydro[1,4]dioxino[2,3-f...)
Affinity DataKi:  1.42E+3nMAssay Description:Displacement of [3H]spiperone from human dopamine D4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295053((S)-2-((4-(1H-Indol-3-yl)-5,6-dihydropyridin-1(2H)...)
Affinity DataIC50:  56.7nMAssay Description:Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295055(2-(4-{[(2S)-8-Methyl-2,3-dihydro[1,4]dioxino[2,3-f...)
Affinity DataIC50:  58nMAssay Description:Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295054((2S)-2-{[4-(6-Fluoroquinolin-2-yl)-1,4-diazepan-1-...)
Affinity DataIC50:  70nMAssay Description:Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295056((2S)-8-Methyl-2-[(4-quinolin-2-yl-1,4-diazepan-1-y...)
Affinity DataIC50:  70nMAssay Description:Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295052(2-(4-{[(2S)-8-Methyl-2,3-dihydro[1,4]dioxino[2,3-f...)
Affinity DataIC50:  102nMAssay Description:Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295058((2S)-8-Methyl-2-{[(2R)-2-methyl-4-quinolin-2-ylpip...)
Affinity DataIC50:  117nMAssay Description:Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295053((S)-2-((4-(1H-Indol-3-yl)-5,6-dihydropyridin-1(2H)...)
Affinity DataIC50:  145nMAssay Description:Antagonist activity at human 5HT transporter expressed in staurosporine treated human JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295063((2S)-2-{[4-(6-Bromoquinolin-2-yl)piperazin-1-yl]me...)
Affinity DataIC50:  156nMAssay Description:Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295062(2-(4-{[(2S)-8-Methyl-2,3-dihydro[1,4]dioxino[2,3-f...)
Affinity DataIC50:  164nMAssay Description:Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295057(2-((3R)-3-Methyl-4-{[(2S)-8-methyl-2,3-dihydro[1,4...)
Affinity DataIC50:  180nMAssay Description:Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295066((2S)-8-Methyl-2-{[4-(6-nitroquinolin-2-yl)piperazi...)
Affinity DataIC50:  294nMAssay Description:Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295061((2S)-8-Methyl-2-({4-[6-(trifluoromethoxy)quinolin-...)
Affinity DataIC50:  588nMAssay Description:Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295064((2S)-2-{[4-(6-Chloroquinolin-2-yl)piperazin-1-yl]m...)
Affinity DataIC50:  781nMAssay Description:Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295059((2S)-8-Methyl-2-{[(2S)-2-methyl-4-quinolin-2-ylpip...)
Affinity DataIC50:  1.90E+3nMAssay Description:Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295065((2S)-2-{[4-(6-Fluoroquinolin-2-yl)piperazin-1-yl]m...)
Affinity DataIC50:  2.17E+3nMAssay Description:Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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