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Found 73 Enz. Inhib. hit(s) with all data for entry = 50030831
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302326((R)-N-((6-fluoro-1-methylnaphthalen-2-yl)methyl)-N...)
Affinity DataKi:  1.60E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302327(CHEMBL568350 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Affinity DataKi:  3.20E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302325((R)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)m...)
Affinity DataKi:  4.20E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302320((R)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide |...)
Affinity DataKi:  7.00E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302317((R)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)a...)
Affinity DataKi:  8.00E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302314(CHEMBL578346 | N-cyclobutyl-N-(piperidin-4-yl)-2-n...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302311((S)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)m...)
Affinity DataKi:  1.10E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302309(CHEMBL567288 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Affinity DataKi:  1.20E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302313(CHEMBL565638 | N-(piperidin-4-yl)-N-propyl-2-napht...)
Affinity DataKi:  1.27E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302310(CHEMBL567944 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302309(CHEMBL567288 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Affinity DataIC50:  1nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302318((R)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)p...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302321((S)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide |...)
Affinity DataIC50:  3nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302327(CHEMBL568350 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302311((S)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)m...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302310(CHEMBL567944 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302326((R)-N-((6-fluoro-1-methylnaphthalen-2-yl)methyl)-N...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302320((R)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide |...)
Affinity DataIC50:  5nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302317((R)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)a...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278564(CHEMBL471036 | Litoxetine | US9511061, Compound A)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302323((R)-3,4-dichloro-N-isopropyl-2-methyl-N-(pyrrolidi...)
Affinity DataIC50:  7nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302316((R)-N-cyclobutyl-N-(pyrrolidin-3-yl)-2-naphthamide...)
Affinity DataIC50:  9nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302314(CHEMBL578346 | N-cyclobutyl-N-(piperidin-4-yl)-2-n...)
Affinity DataIC50:  10nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302308(CHEMBL567289 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Affinity DataIC50:  10nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302322((R)-3,4-dichloro-N-ethyl-2-methyl-N-(pyrrolidin-3-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302319((R)-N-cyclopentyl-N-(pyrrolidin-3-yl)-2-naphthamid...)
Affinity DataIC50:  12nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302315((R)-N-isopropyl-N-(pyrrolidin-3-yl)-2-naphthamide ...)
Affinity DataIC50:  15nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302324((S)-3,4-dichloro-2-methyl-N-neopentyl-N-(pyrrolidi...)
Affinity DataIC50:  15nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302325((R)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)m...)
Affinity DataIC50:  17nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302321((S)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide |...)
Affinity DataIC50:  24nMAssay Description:Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302313(CHEMBL565638 | N-(piperidin-4-yl)-N-propyl-2-napht...)
Affinity DataIC50:  28.3nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302329((R)-3,4-dichloro-N,2-dimethyl-N-(pyrrolidin-3-yl)b...)
Affinity DataIC50:  58nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302318((R)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)p...)
Affinity DataIC50:  224nMAssay Description:Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302318((R)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)p...)
Affinity DataIC50:  266nMAssay Description:Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302309(CHEMBL567288 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Affinity DataIC50:  339nMAssay Description:Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302324((S)-3,4-dichloro-2-methyl-N-neopentyl-N-(pyrrolidi...)
Affinity DataIC50:  357nMAssay Description:Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302311((S)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)m...)
Affinity DataIC50:  370nMAssay Description:Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302328((R)-3,4-dichloro-N-methyl-N-(pyrrolidin-3-yl)benza...)
Affinity DataIC50: >400nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302312(CHEMBL577272 | N-(piperidin-4-yl)-2-naphthamide)
Affinity DataIC50: >400nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302319((R)-N-cyclopentyl-N-(pyrrolidin-3-yl)-2-naphthamid...)
Affinity DataIC50:  677nMAssay Description:Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302317((R)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)a...)
Affinity DataIC50:  726nMAssay Description:Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302326((R)-N-((6-fluoro-1-methylnaphthalen-2-yl)methyl)-N...)
Affinity DataIC50:  735nMAssay Description:Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302321((S)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide |...)
Affinity DataIC50:  744nMAssay Description:Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302320((R)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide |...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302308(CHEMBL567289 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302309(CHEMBL567288 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302308(CHEMBL567289 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278564(CHEMBL471036 | Litoxetine | US9511061, Compound A)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302310(CHEMBL567944 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302327(CHEMBL568350 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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