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Found 72 Enz. Inhib. hit(s) with all data for entry = 50031711
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50159110(1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piper...)
Affinity DataKi:  0.970nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317720((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(4-fluo...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317711(((2R,4S)-4-(4-chloro-3-methylphenoxy)pyrrolidin-2-...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317706(1-((2R,4S)-2-(4-cyclobutyl-1,4-diazepane-1-carbony...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317698(1-((2R,4S)-2-(4-cyclobutyl-1,4-diazepane-1-carbony...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317700((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(4-fluo...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317716((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(4-fluo...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317701(((2R,4S)-4-(4-chlorophenoxy)pyrrolidin-2-yl)(4-cyc...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317728(1-((2R,4S)-2-(4-cyclopentyl-1,4-diazepane-1-carbon...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317703(4-((3S,5R)-5-(4-cyclobutyl-1,4-diazepane-1-carbony...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317702(((2R,4S)-4-(3-chlorophenoxy)pyrrolidin-2-yl)(4-cyc...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317686((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(pyridi...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317688(1-((2R,4S)-2-(4-cyclobutyl-1,4-diazepane-1-carbony...)
Affinity DataKi:  2.70nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317708((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(o-toly...)
Affinity DataKi:  2.80nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317713((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(4-(met...)
Affinity DataKi:  2.80nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317705(4-((3S,5R)-5-(4-cyclopentyl-1,4-diazepane-1-carbon...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317699((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(3-fluo...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317687(1-((2R,4S)-2-(4-cyclobutyl-1,4-diazepane-1-carbony...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317714((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(4-(tri...)
Affinity DataKi:  4.10nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317704((4-cyclopentyl-1,4-diazepan-1-yl)((2R,4S)-4-(4-flu...)
Affinity DataKi:  4.10nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317685((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(pyridi...)
Affinity DataKi:  4.60nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317710((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(p-toly...)
Affinity DataKi:  4.70nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317712((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(3-meth...)
Affinity DataKi:  5nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317709((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(m-toly...)
Affinity DataKi:  5.20nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317707((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-phenoxy...)
Affinity DataKi:  5.30nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317684((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(thioph...)
Affinity DataKi:  5.30nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317689(1-((2R,4S)-2-(4-cyclobutyl-1,4-diazepane-1-carbony...)
Affinity DataKi:  5.40nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317690(1-((2R,4S)-2-(4-cyclobutyl-1,4-diazepane-1-carbony...)
Affinity DataKi:  6nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317727((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-1-(cyclop...)
Affinity DataKi:  7nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317726((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-1-(cyclop...)
Affinity DataKi:  7.5nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317694((S)-(2-benzylpyrrolidin-2-yl)(4-cyclobutyl-1,4-dia...)
Affinity DataKi:  11nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317717((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(4-fluo...)
Affinity DataKi:  12nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317724(1-((2R,4S)-4-(3-fluorophenoxy)-2-(4-isobutyl-1,4-d...)
Affinity DataKi:  13nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317718((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-1-cyclopr...)
Affinity DataKi:  13nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317725((2R,4S)-ethyl 2-(4-cyclobutyl-1,4-diazepane-1-carb...)
Affinity DataKi:  16nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317691((S)-(4-cyclobutyl-1,4-diazepan-1-yl)(2-(4-fluorobe...)
Affinity DataKi:  16nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317719((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-1-cyclobu...)
Affinity DataKi:  17nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317715(4-((3S,5R)-5-(4-cyclopropyl-1,4-diazepane-1-carbon...)
Affinity DataKi:  23nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317698(1-((2R,4S)-2-(4-cyclobutyl-1,4-diazepane-1-carbony...)
Affinity DataKi:  27nMAssay Description:Binding affinity to rat histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317677((4-cyclobutyl-1,4-diazepan-1-yl)((2S,4R)-4-(3-fluo...)
Affinity DataKi:  37nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317692((S)-(4-cyclobutyl-1,4-diazepan-1-yl)(2-(3-fluorobe...)
Affinity DataKi:  44nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317678(4-((3R,5S)-5-(4-cyclobutyl-1,4-diazepane-1-carbony...)
Affinity DataKi:  45nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317674(1-((2S,4S)-2-(4-cyclobutyl-1,4-diazepane-1-carbony...)
Affinity DataKi:  50nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317723(1-((2R,4S)-4-(3-fluorophenoxy)-2-(4-isopropyl-1,4-...)
Affinity DataKi:  51nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317681((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4R)-4-(3-fluo...)
Affinity DataKi:  54nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317676((4-cyclobutyl-1,4-diazepan-1-yl)((2S,4S)-1-cyclopr...)
Affinity DataKi:  55nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317729(1-((2R,4S)-4-(3-fluorophenoxy)-2-(4-(tetrahydro-2H...)
Affinity DataKi:  69nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317682(4-((3R,5R)-5-(4-cyclobutyl-1,4-diazepane-1-carbony...)
Affinity DataKi:  89nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317679((4-cyclobutyl-1,4-diazepan-1-yl)((2S,4R)-4-(4-(met...)
Affinity DataKi:  143nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317730(1-((2R,4S)-2-(4-benzyl-1,4-diazepane-1-carbonyl)-4...)
Affinity DataKi:  150nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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