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Found 90 Enz. Inhib. hit(s) with all data for entry = 50039364
TargetNociceptin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335574((1-{4-[2-(4-Chlorophenyl)-1H-benzimidazol-1-yl]pip...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataKi:  0.390nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335575((1-{4-[2-(3-Chloro-4-fluorophenyl)-1H-benzimidazol...)
Affinity DataKi:  0.730nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335568((1-{4-[2-(3-Methylpiperazin-1-yl)-1H-benzimidazol-...)
Affinity DataKi:  0.960nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335570(CHEMBL1650844 | {1-[4-(2-{Hexahydropyrrolo[3,4-c]p...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335567((1-{4-[2-(4-Methylpiperazin-1-yl)-1H-benzimidazol-...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335576((1-{4-[2-(3-Chloro-4-fluorophenyl)-1H-benzimidazol...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335569(1-{1-[1-(Hydroxymethyl)cyclooctyl]piperidin-4-yl}-...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335573((1-{4-[2-(3,3-Dimethylpiperazin-1-yl)-1H-benzimida...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335571(CHEMBL1650845 | {1-[4-(2-{5-Benzylhexahydropyrrolo...)
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335569(1-{1-[1-(Hydroxymethyl)cyclooctyl]piperidin-4-yl}-...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]DAMGO from human MOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335571(CHEMBL1650845 | {1-[4-(2-{5-Benzylhexahydropyrrolo...)
Affinity DataKi:  39nMAssay Description:Displacement of [3H]enadoline from human KOP receptor expressed in HEK-293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335572(CHEMBL1650846 | Methyl 1-{4-[2-(4-methylpiperazin-...)
Affinity DataKi:  81nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335571(CHEMBL1650845 | {1-[4-(2-{5-Benzylhexahydropyrrolo...)
Affinity DataKi:  128nMAssay Description:Displacement of [3H]DAMGO from human MOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335574((1-{4-[2-(4-Chlorophenyl)-1H-benzimidazol-1-yl]pip...)
Affinity DataKi:  178nMAssay Description:Displacement of [3H]DAMGO from human MOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335570(CHEMBL1650844 | {1-[4-(2-{Hexahydropyrrolo[3,4-c]p...)
Affinity DataKi:  201nMAssay Description:Displacement of [3H]DAMGO from human MOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335574((1-{4-[2-(4-Chlorophenyl)-1H-benzimidazol-1-yl]pip...)
Affinity DataKi:  205nMAssay Description:Displacement of [3H]DPDPE from human DOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335567((1-{4-[2-(4-Methylpiperazin-1-yl)-1H-benzimidazol-...)
Affinity DataKi:  229nMAssay Description:Displacement of [3H]DAMGO from human MOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335569(1-{1-[1-(Hydroxymethyl)cyclooctyl]piperidin-4-yl}-...)
Affinity DataKi:  239nMAssay Description:Displacement of [3H]enadoline from human KOP receptor expressed in HEK-293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335577(1-{4-[2-(4-Methylpiperazin-1-yl)-1H-benzimidazol-1...)
Affinity DataKi: >250nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335571(CHEMBL1650845 | {1-[4-(2-{5-Benzylhexahydropyrrolo...)
Affinity DataKi:  258nMAssay Description:Displacement of [3H]DPDPE from human DOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335568((1-{4-[2-(3-Methylpiperazin-1-yl)-1H-benzimidazol-...)
Affinity DataKi:  275nMAssay Description:Displacement of [3H]enadoline from human KOP receptor expressed in HEK-293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335575((1-{4-[2-(3-Chloro-4-fluorophenyl)-1H-benzimidazol...)
Affinity DataKi:  302nMAssay Description:Displacement of [3H]DAMGO from human MOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335572(CHEMBL1650846 | Methyl 1-{4-[2-(4-methylpiperazin-...)
Affinity DataKi:  312nMAssay Description:Displacement of [3H]DPDPE from human DOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335567((1-{4-[2-(4-Methylpiperazin-1-yl)-1H-benzimidazol-...)
Affinity DataKi:  333nMAssay Description:Displacement of [3H]enadoline from human KOP receptor expressed in HEK-293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335573((1-{4-[2-(3,3-Dimethylpiperazin-1-yl)-1H-benzimida...)
Affinity DataKi:  387nMAssay Description:Displacement of [3H]enadoline from human KOP receptor expressed in HEK-293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335568((1-{4-[2-(3-Methylpiperazin-1-yl)-1H-benzimidazol-...)
Affinity DataKi: >450nMAssay Description:Displacement of [3H]DAMGO from human MOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335573((1-{4-[2-(3,3-Dimethylpiperazin-1-yl)-1H-benzimida...)
Affinity DataKi: >450nMAssay Description:Displacement of [3H]DAMGO from human MOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335577(1-{4-[2-(4-Methylpiperazin-1-yl)-1H-benzimidazol-1...)
Affinity DataKi: >450nMAssay Description:Displacement of [3H]DAMGO from human MOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335576((1-{4-[2-(3-Chloro-4-fluorophenyl)-1H-benzimidazol...)
Affinity DataKi: >450nMAssay Description:Displacement of [3H]DAMGO from human MOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335572(CHEMBL1650846 | Methyl 1-{4-[2-(4-methylpiperazin-...)
Affinity DataKi: >450nMAssay Description:Displacement of [3H]DAMGO from human MOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335573((1-{4-[2-(3,3-Dimethylpiperazin-1-yl)-1H-benzimida...)
Affinity DataKi: >500nMAssay Description:Displacement of [3H]DPDPE from human DOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335568((1-{4-[2-(3-Methylpiperazin-1-yl)-1H-benzimidazol-...)
Affinity DataKi: >500nMAssay Description:Displacement of [3H]DPDPE from human DOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335577(1-{4-[2-(4-Methylpiperazin-1-yl)-1H-benzimidazol-1...)
Affinity DataKi: >570nMAssay Description:Displacement of [3H]enadoline from human KOP receptor expressed in HEK-293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335574((1-{4-[2-(4-Chlorophenyl)-1H-benzimidazol-1-yl]pip...)
Affinity DataKi: >570nMAssay Description:Displacement of [3H]enadoline from human KOP receptor expressed in HEK-293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335572(CHEMBL1650846 | Methyl 1-{4-[2-(4-methylpiperazin-...)
Affinity DataKi: >570nMAssay Description:Displacement of [3H]enadoline from human KOP receptor expressed in HEK-293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335570(CHEMBL1650844 | {1-[4-(2-{Hexahydropyrrolo[3,4-c]p...)
Affinity DataKi: >577nMAssay Description:Displacement of [3H]enadoline from human KOP receptor expressed in HEK-293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335567((1-{4-[2-(4-Methylpiperazin-1-yl)-1H-benzimidazol-...)
Affinity DataKi:  679nMAssay Description:Displacement of [3H]DPDPE from human DOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]DAMGO from human MOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]enadoline from human KOP receptor expressed in HEK-293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]DPDPE from human DOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335570(CHEMBL1650844 | {1-[4-(2-{Hexahydropyrrolo[3,4-c]p...)
Affinity DataKi:  3.70E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335569(1-{1-[1-(Hydroxymethyl)cyclooctyl]piperidin-4-yl}-...)
Affinity DataKi: >5.00E+3nMAssay Description:Displacement of [3H]DPDPE from human DOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335570(CHEMBL1650844 | {1-[4-(2-{Hexahydropyrrolo[3,4-c]p...)
Affinity DataKi: >5.00E+3nMAssay Description:Displacement of [3H]DPDPE from human DOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM15581(CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)
Affinity DataIC50:  0.00490nMAssay Description:Inhibition of human monoamine oxidase AMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM15579(CHEMBL972 | DEPRENYL | L-Deprenyl | N-methyl-N-[(2...)
Affinity DataIC50:  0.0170nMAssay Description:Inhibition of human monoamine oxidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50260153(Apamin | CHEMBL525408 | Octadecapeptide venom)
Affinity DataIC50:  0.0240nMAssay Description:Inhibition of rat SK Calcium channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50022775((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)
Affinity DataIC50:  0.0430nMAssay Description:Inhibition of human acetylcholine esteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetType-2 angiotensin II receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009338((S)-2-((S)-1-((S)-2-((S)-2-((S)-2-((S)-2-((S)-5-(d...)
Affinity DataIC50:  0.530nMAssay Description:Inhibition of human angiotensin II AT2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009338((S)-2-((S)-1-((S)-2-((S)-2-((S)-2-((S)-2-((S)-5-(d...)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of human angiotensin II AT1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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