Compile Data Set for Download or QSAR
maximum 50k data
Found 75 Enz. Inhib. hit(s) with all data for entry = 50032882
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297308((-)-Dimethyl-{2-[3-((R)-1-pyrazin-2-yl-ethyl)-1H-i...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336074(2-((2-(2-(pyrrolidin-1-yl)ethyl)-1H-inden-3-yl)met...)
Affinity DataKi:  2.80nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297305(CHEMBL559251 | Dimethyl-[2-(3-pyrazin-2ylmethyl-1H...)
Affinity DataKi:  4nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336073(2-((2-(2-(azetidin-1-yl)ethyl)-1H-inden-3-yl)methy...)
Affinity DataKi:  4.30nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336086((R)-N-methyl-2-(3-(1-(pyrazin-2-yl)ethyl)-1H-inden...)
Affinity DataKi:  4.90nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336080((R)-N-methyl-2-(3-(1-(pyrazin-2-yl)ethyl)-1H-inden...)
Affinity DataKi:  6.70nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336066(CHEMBL1669405 | N-ethyl-N-methyl-2-(3-(pyrazin-2-y...)
Affinity DataKi:  7.20nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336079((R)-N-(furan-2-ylmethyl)-N-methyl-2-(3-(1-(pyrazin...)
Affinity DataKi:  8.10nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336083((R)-N-((1H-imidazol-2-yl)methyl)-N-methyl-2-(3-(1-...)
Affinity DataKi:  8.80nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336078(2-((2-(2-(3-fluoropyrrolidin-1-yl)ethyl)-1H-inden-...)
Affinity DataKi:  10.5nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336069((R)-2-fluoro-N-methyl-N-(2-(3-(1-(pyrazin-2-yl)eth...)
Affinity DataKi:  13nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336085((R)-N-methyl-2-(3-(1-(pyrazin-2-yl)ethyl)-1H-inden...)
Affinity DataKi:  13.9nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336088((R)-N-methyl-2-(3-(1-(pyrazin-2-yl)ethyl)-1H-inden...)
Affinity DataKi:  15.2nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336068(2-fluoro-N-methyl-N-(2-(3-(pyrazin-2-ylmethyl)-1H-...)
Affinity DataKi:  24nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336087((R)-N-methyl-2-(3-(1-(pyrazin-2-yl)ethyl)-1H-inden...)
Affinity DataKi:  24.7nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336084((R)-N-methyl-N-((1-methyl-1H-imidazol-2-yl)methyl)...)
Affinity DataKi:  28nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336070((R)-2-(methyl(2-(3-(1-(pyrazin-2-yl)ethyl)-1H-inde...)
Affinity DataKi:  32nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336067(CHEMBL1669406 | N-methyl-N-(2-(3-(pyrazin-2-ylmeth...)
Affinity DataKi:  41nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336081((R)-N-methyl-2-(3-(1-(pyrazin-2-yl)ethyl)-1H-inden...)
Affinity DataKi:  48nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336075(2-((2-(2-(3-fluoroazetidin-1-yl)ethyl)-1H-inden-3-...)
Affinity DataKi:  49nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336072((R)-3,3,3-trifluoro-N-methyl-N-(2-(3-(1-(pyrazin-2...)
Affinity DataKi:  91nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336071((R)-3-(methyl(2-(3-(1-(pyrazin-2-yl)ethyl)-1H-inde...)
Affinity DataKi:  109nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336082((R)-N-methyl-N-(oxazol-2-ylmethyl)-2-(3-(1-(pyrazi...)
Affinity DataKi:  162nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336077(2-((2-(2-(3,3-difluoropyrrolidin-1-yl)ethyl)-1H-in...)
Affinity DataKi:  249nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336076(2-((2-(2-(3,3-difluoroazetidin-1-yl)ethyl)-1H-inde...)
Affinity DataKi:  4.61E+3nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336067(CHEMBL1669406 | N-methyl-N-(2-(3-(pyrazin-2-ylmeth...)
Affinity DataIC50:  973nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336086((R)-N-methyl-2-(3-(1-(pyrazin-2-yl)ethyl)-1H-inden...)
Affinity DataIC50:  1.28E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336077(2-((2-(2-(3,3-difluoropyrrolidin-1-yl)ethyl)-1H-in...)
Affinity DataIC50:  1.41E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336080((R)-N-methyl-2-(3-(1-(pyrazin-2-yl)ethyl)-1H-inden...)
Affinity DataIC50:  1.43E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336084((R)-N-methyl-N-((1-methyl-1H-imidazol-2-yl)methyl)...)
Affinity DataIC50:  1.54E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336080((R)-N-methyl-2-(3-(1-(pyrazin-2-yl)ethyl)-1H-inden...)
Affinity DataIC50:  1.83E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336069((R)-2-fluoro-N-methyl-N-(2-(3-(1-(pyrazin-2-yl)eth...)
Affinity DataIC50:  2.61E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336079((R)-N-(furan-2-ylmethyl)-N-methyl-2-(3-(1-(pyrazin...)
Affinity DataIC50:  2.75E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336081((R)-N-methyl-2-(3-(1-(pyrazin-2-yl)ethyl)-1H-inden...)
Affinity DataIC50:  2.82E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336068(2-fluoro-N-methyl-N-(2-(3-(pyrazin-2-ylmethyl)-1H-...)
Affinity DataIC50:  3.09E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336074(2-((2-(2-(pyrrolidin-1-yl)ethyl)-1H-inden-3-yl)met...)
Affinity DataIC50:  3.39E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336076(2-((2-(2-(3,3-difluoroazetidin-1-yl)ethyl)-1H-inde...)
Affinity DataIC50:  3.87E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336067(CHEMBL1669406 | N-methyl-N-(2-(3-(pyrazin-2-ylmeth...)
Affinity DataIC50:  4.04E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336078(2-((2-(2-(3-fluoropyrrolidin-1-yl)ethyl)-1H-inden-...)
Affinity DataIC50:  4.29E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336066(CHEMBL1669405 | N-ethyl-N-methyl-2-(3-(pyrazin-2-y...)
Affinity DataIC50:  4.35E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336079((R)-N-(furan-2-ylmethyl)-N-methyl-2-(3-(1-(pyrazin...)
Affinity DataIC50:  4.36E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336083((R)-N-((1H-imidazol-2-yl)methyl)-N-methyl-2-(3-(1-...)
Affinity DataIC50:  4.42E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336085((R)-N-methyl-2-(3-(1-(pyrazin-2-yl)ethyl)-1H-inden...)
Affinity DataIC50:  4.78E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336082((R)-N-methyl-N-(oxazol-2-ylmethyl)-2-(3-(1-(pyrazi...)
Affinity DataIC50:  4.84E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336072((R)-3,3,3-trifluoro-N-methyl-N-(2-(3-(1-(pyrazin-2...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336084((R)-N-methyl-N-((1-methyl-1H-imidazol-2-yl)methyl)...)
Affinity DataIC50:  5.68E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336085((R)-N-methyl-2-(3-(1-(pyrazin-2-yl)ethyl)-1H-inden...)
Affinity DataIC50:  5.71E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336083((R)-N-((1H-imidazol-2-yl)methyl)-N-methyl-2-(3-(1-...)
Affinity DataIC50:  5.85E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50336075(2-((2-(2-(3-fluoroazetidin-1-yl)ethyl)-1H-inden-3-...)
Affinity DataIC50:  6.47E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297305(CHEMBL559251 | Dimethyl-[2-(3-pyrazin-2ylmethyl-1H...)
Affinity DataIC50:  6.68E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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