Compile Data Set for Download or QSAR
maximum 50k data
Found 32 Enz. Inhib. hit(s) with all data for entry = 50032886
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336144((1R,3S)-4-chloro-N-(3-hydroxycyclohexyl)-5-(4-(tri...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336143((1S,3R)-4-chloro-N-(3-hydroxycyclohexyl)-5-(4-(tri...)
Affinity DataIC50:  7.40nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336162(4-chloro-N-cyclopentyl-5-(4-(trifluoromethyl)pheny...)
Affinity DataIC50:  15nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336140((1R,3S)-4-chloro-N-(3-hydroxycyclopentyl)-5-(4-(tr...)
Affinity DataIC50:  23nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336136(4-chloro-N-(tetrahydro-2H-pyran-4-yl)-5-(4-(triflu...)
Affinity DataIC50:  43nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336159(4-bromo-N-cyclopentyl-5-(4-(trifluoromethyl)phenyl...)
Affinity DataIC50:  46nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336147(CHEMBL1669535 | cis-(+/-)-4-chloro-N-(2-(hydroxyme...)
Affinity DataIC50:  48nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336141((1S,3R)-4-chloro-N-(3-hydroxycyclopentyl)-5-(4-(tr...)
Affinity DataIC50:  55nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336142(CHEMBL1669530 | Cis-(+/-)-4-chloro-N-(2-hydroxycyc...)
Affinity DataIC50:  65nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336152((1R,3S)-4-chloro-5-(3,4-difluorophenyl)-N-(3-hydro...)
Affinity DataIC50:  79nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336134(4-chloro-N-cyclobutyl-5-(4-(trifluoromethyl)phenyl...)
Affinity DataIC50:  87nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336135(4-chloro-N-cyclohexyl-5-(4-(trifluoromethyl)phenyl...)
Affinity DataIC50:  92nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336161(CHEMBL1669549 | N-cyclopentyl-4-fluoro-5-(4-(trifl...)
Affinity DataIC50:  112nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336148(4-chloro-N-(3-hydroxyphenyl)-5-(4-(trifluoromethyl...)
Affinity DataIC50:  118nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336146(CHEMBL1669534 | cis-(+/-)4-chloro-N-(3,5-dihydroxy...)
Affinity DataIC50:  120nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336151((1R,3S)-4-chloro-5-(4-fluorophenyl)-N-(3-hydroxycy...)
Affinity DataIC50:  141nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336145(CHEMBL1669533 | trans-(+/-)4-chloro-N-(3-hydroxycy...)
Affinity DataIC50:  149nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336138((1R,3R)-4-chloro-N-(3-hydroxycyclopentyl)-5-(4-(tr...)
Affinity DataIC50:  197nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336160(CHEMBL1669548 | N-cyclopentyl-5-(4-(trifluoromethy...)
Affinity DataIC50:  201nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336132(4-chloro-N-(4-hydroxybutyl)-5-(4-(trifluoromethyl)...)
Affinity DataIC50:  238nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336153((4-chloro-5-(4-(trifluoromethyl)phenyl)isoxazol-3-...)
Affinity DataIC50:  263nMAssay Description:Agonist activity at human TRPV1 expressed in CHO cells assessed as capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336155(4-bromo-5-(4-chlorophenyl)-N-cyclopentylisoxazole-...)
Affinity DataIC50:  370nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336156(4-bromo-N-cyclopentyl-5-(4-fluorophenyl)isoxazole-...)
Affinity DataIC50:  377nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336137(CHEMBL1669526 | Trans-4-chloro-N-((1r,4r)-4-hydrox...)
Affinity DataIC50:  392nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336150((1R,3S)-4-chloro-5-(3,4-difluorophenyl)-N-(3-hydro...)
Affinity DataIC50:  404nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336157(4-bromo-5-(4-bromophenyl)-N-cyclopentylisoxazole-3...)
Affinity DataIC50:  410nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336149((1R,3S)-4-chloro-5-(4-fluorophenyl)-N-(3-hydroxycy...)
Affinity DataIC50:  434nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336131(4-chloro-N-(3-hydroxypropyl)-5-(4-(trifluoromethyl...)
Affinity DataIC50:  595nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336139((1S,3S)-4-chloro-N-(3-hydroxycyclopentyl)-5-(4-(tr...)
Affinity DataIC50:  762nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336158(4-bromo-N-cyclopentyl-5-(4-(trifluoromethoxy)pheny...)
Affinity DataIC50:  1.25E+3nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336133(4-chloro-N-(3-methoxypropyl)-5-(4-(trifluoromethyl...)
Affinity DataIC50:  2.21E+3nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM50336154(4-bromo-5-(3-chlorophenyl)-N-cyclopentylisoxazole-...)
Affinity DataIC50:  4.22E+3nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed