Compile Data Set for Download or QSAR
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Found 20 Enz. Inhib. hit(s) with all data for entry = 50004549
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
I2Bm

Curated by ChEMBL
LigandPNGBDBM50204862(CHEMBL436521 | N-(2-((4-benzylpiperidin-1-yl)methy...)
Affinity DataKi:  0.990nMAssay Description:Binding affinity to NR1/NR2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
I2Bm

Curated by ChEMBL
LigandPNGBDBM50474796(CHEMBL64941)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to NR1/NR2B receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
I2Bm

Curated by ChEMBL
LigandPNGBDBM50204862(CHEMBL436521 | N-(2-((4-benzylpiperidin-1-yl)methy...)
Affinity DataIC50:  1.40nMAssay Description:Antagonist activity at human NR1a/NR2B receptor expressed in mouse fibroblast LMTK cells assessed as inhibition of Glu/Gly induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
I2Bm

Curated by ChEMBL
LigandPNGBDBM50149695(2-(4-Benzyl-piperidin-1-yl)-2-oxo-N-(2-oxo-2,3-dih...)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]-Ro-256981 from recombinant NR1/NR2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
I2Bm

Curated by ChEMBL
LigandPNGBDBM50149684(2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(2-...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity against NR1/NR2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
I2Bm

Curated by ChEMBL
LigandPNGBDBM50149693(2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(2-...)
Affinity DataIC50:  5nMAssay Description:Displacement of [3H]-Ro-256981 from recombinant NR1/NR2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
I2Bm

Curated by ChEMBL
LigandPNGBDBM50149684(2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(2-...)
Affinity DataIC50:  6nMAssay Description:Displacement of [3H]-Ro-256981 from recombinant NR1/NR2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
I2Bm

Curated by ChEMBL
LigandPNGBDBM50149689(2-(4-Benzyl-piperidin-1-yl)-2-oxo-N-(2-oxo-2,3-dih...)
Affinity DataIC50:  8nMAssay Description:Displacement of [3H]-Ro-256981 from recombinant NR1/NR2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
I2Bm

Curated by ChEMBL
LigandPNGBDBM50143890(2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimidazol...)
Affinity DataIC50:  8.20nMAssay Description:Antagonist activity at NR1/NR2B receptor assessed as inhibition of Glu/Gly induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
I2Bm

Curated by ChEMBL
LigandPNGBDBM50474796(CHEMBL64941)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at human NR1a/NR2B receptor expressed in mouse fibroblast LMTK cells assessed as inhibition of Glu/Gly induced Ca2+ influxMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
I2Bm

Curated by ChEMBL
LigandPNGBDBM50474796(CHEMBL64941)
Affinity DataIC50:  47nMAssay Description:Antagonist activity against NR1a/NR2B receptor transfected in human HEK293 cells assessed as inhibition of NMDA-induced Ca2+ influxMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
I2Bm

Curated by ChEMBL
LigandPNGBDBM50204862(CHEMBL436521 | N-(2-((4-benzylpiperidin-1-yl)methy...)
Affinity DataIC50:  50nMAssay Description:Antagonist activity against NR1a/NR2B receptor transfected in human HEK293 cells assessed as inhibition of NMDA-induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
I2Bm

Curated by ChEMBL
LigandPNGBDBM50483964(CHEMBL1801979)
Affinity DataIC50:  58nMAssay Description:Antagonist activity against NR1a/NR2B receptor transfected in human HEK293 cells assessed as inhibition of NMDA-induced Ca2+ influxMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
I2Bm

Curated by ChEMBL
LigandPNGBDBM50083351((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)
Affinity DataIC50:  66nMAssay Description:Antagonist activity at NR1/NR2B receptor assessed as inhibition of Glu/Gly induced Ca2+ influxMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
I2Bm

Curated by ChEMBL
LigandPNGBDBM50149684(2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(2-...)
Affinity DataIC50:  70nMAssay Description:Antagonist activity against NR1a/NR2B receptor transfected in human HEK293 cells assessed as inhibition of NMDA-induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
I2Bm

Curated by ChEMBL
LigandPNGBDBM50083351((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)
Affinity DataIC50:  177nMAssay Description:Antagonist activity against NR1a/NR2B receptor transfected in human HEK293 cells assessed as inhibition of NMDA-induced Ca2+ influxMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
I2Bm

Curated by ChEMBL
LigandPNGBDBM50143890(2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimidazol...)
Affinity DataIC50:  209nMAssay Description:Antagonist activity against NR1a/NR2B receptor transfected in human HEK293 cells assessed as inhibition of NMDA-induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
I2Bm

Curated by ChEMBL
LigandPNGBDBM50083351((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)
Affinity DataIC50:  340nMAssay Description:Antagonist activity against NR1/NR2B receptor expressed in xenopus oocytes assessed as inhibition of NMDA induced Ca2+ influxMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
I2Bm

Curated by ChEMBL
LigandPNGBDBM50483962(CHEMBL1802035)
Affinity DataIC50:  830nMAssay Description:Antagonist activity against NR1a/NR2B receptor transfected in human HEK293 cells assessed as inhibition of NMDA-induced Ca2+ influxMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
I2Bm

Curated by ChEMBL
LigandPNGBDBM50483963(CHEMBL1802036)
Affinity DataIC50:  840nMAssay Description:Antagonist activity against NR1a/NR2B receptor transfected in human HEK293 cells assessed as inhibition of NMDA-induced Ca2+ influxMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed