Compile Data Set for Download or QSAR
maximum 50k data
Found 51 Enz. Inhib. hit(s) with all data for entry = 50040470
TargetATP-citrate synthase(Rattus norvegicus)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50036210((2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid ...)
Affinity DataKi:  150nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
TargetATP-citrate synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394668(CHEMBL2163366)
Affinity DataKi:  220nMAssay Description:Inhibition of human recombinant ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM24567((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)
Affinity DataKi:  280nMAssay Description:Antagonist activity at recombinant FASN thioesterase domain by fluorigenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetATP-citrate synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394671(CHEMBL2165260)
Affinity DataKi:  340nMAssay Description:Inhibition of human recombinant ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394671(CHEMBL2165260)
Affinity DataKi:  340nMAssay Description:Inhibition of human recombinant ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394670(CHEMBL2165263)
Affinity DataKi:  370nMAssay Description:Inhibition of human recombinant ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM24984((5E)-1-(3,5-dimethylphenyl)-5-[(5-phenylfuran-2-yl...)
Affinity DataKi:  380nMAssay Description:Antagonist activity at human recombinant FASN thioesterase domain by fluorigenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50066676((2S,3R)-2-[(R)-8-(2,4-Dichloro-phenyl)-2-hydroxy-o...)
Affinity DataKi:  550nMAssay Description:Inhibition of human recombinant ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394671(CHEMBL2165260)
Affinity DataKi:  580nMAssay Description:Inhibition of human recombinant ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394672(CHEMBL2165259)
Affinity DataKi:  620nMAssay Description:Inhibition of human recombinant ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394678(CHEMBL2165261)
Affinity DataKi:  700nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394669(CHEMBL2165264)
Affinity DataKi:  710nMAssay Description:Inhibition of human recombinant ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50066683((S)-2-((R)-8-(2,4-dichlorophenyl)-2-hydroxyoctyl)-...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of human recombinant ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50066683((S)-2-((R)-8-(2,4-dichlorophenyl)-2-hydroxyoctyl)-...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394664(CHEMBL2165413)
Affinity DataKi:  2.50E+3nMAssay Description:Antagonist activity at recombinant FASN thioesterase domain by fluorigenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50018569(3,3,14,14-Tetramethyl-hexadecanedioic acid | CHEMB...)
Affinity DataKi:  3.00E+3nMAssay Description:Competitive inhibition of rat liver ACLY using CoA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM15361((1aR,2Z,4E,14R,15aR)-8-chloro-9,11-dihydroxy-14-me...)
Affinity DataKi:  7.00E+3nMAssay Description:Competitive inhibition of rat liver ACLY using ATP as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50036210((2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid ...)
Affinity DataKi:  8.00E+3nMAssay Description:Inhibition of rat liver ACLY by fluorimetric analysisMore data for this Ligand-Target Pair
TargetATP-citrate synthase(Rattus norvegicus)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM15361((1aR,2Z,4E,14R,15aR)-8-chloro-9,11-dihydroxy-14-me...)
Affinity DataKi:  1.30E+4nMAssay Description:Competitive inhibition of rat liver ACLY using citrate as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394677(CHEMBL2165262)
Affinity DataKi:  1.50E+4nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50018569(3,3,14,14-Tetramethyl-hexadecanedioic acid | CHEMB...)
Affinity DataKi:  1.60E+4nMAssay Description:Competitive inhibition of rat liver ACLY using citrate as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394676(CHEMBL2165252)
Affinity DataKi:  1.80E+4nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394667(CHEMBL2165253)
Affinity DataKi:  5.00E+4nMAssay Description:Inhibition of rat liver ACLY by fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50368516(CHEMBL1627232)
Affinity DataKi:  2.50E+5nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394661(CHEMBL2165265)
Affinity DataIC50:  15.8nMAssay Description:Reversible inhibition of human recombinant FASN ketoreductase siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394674(CHEMBL2165254)
Affinity DataIC50:  283nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394658(CHEMBL2165411)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of human ACC2 using acetyl coA as substrate and [14C]NaHCO3 incubated for 5 mins prior to substrate addition by liquid scintillation count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Gallus gallus (Chicken))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50362887(AVICULARIN)
Affinity DataIC50:  6.15E+3nMAssay Description:Inhibition of chicken liver FASNMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394675(PURPURONE)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Gallus gallus (Chicken))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50318454(CHEMBL123040 | Diallyl trisulfide | diallyltrisulf...)
Affinity DataIC50:  8.37E+3nMAssay Description:Inhibition of chicken liver FASNMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394660(CHEMBL2165409)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human recombinant FASN thioesterase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394659(CHEMBL2165410)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human recombinant FASN thioesterase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Gallus gallus (Chicken))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50148911((3beta)-3-hydroxyurs-12-en-28-oic acid | 3beta-hyd...)
Affinity DataIC50:  1.31E+4nMAssay Description:Inhibition of chicken liver FASNMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Gallus gallus (Chicken))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394659(CHEMBL2165410)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of chicken liver FASN ketoreductase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50009248((2R,3S)-3-((4E,7E)-Nona-4,7-dienoyl)-oxirane-2-car...)
Affinity DataIC50:  2.19E+4nMAssay Description:Inhibition of FASN in human A375 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Gallus gallus (Chicken))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394660(CHEMBL2165409)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of chicken liver FASN ketoreductase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50256128((2R,3S)-4-methylene-2-octyl-5-oxotetrahydrofuran-3...)
Affinity DataIC50:  3.24E+4nMAssay Description:Inhibition of FASN in human A375 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Gallus gallus (Chicken))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50153015((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
Affinity DataIC50:  4.20E+4nMAssay Description:Inhibition of chicken liver FASN after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Gallus gallus (Chicken))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50070942((-)-Epigallocatechin gallate | (-)-Epigallocatechi...)
Affinity DataIC50:  5.20E+4nMAssay Description:Inhibition of chicken liver FASNMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50256128((2R,3S)-4-methylene-2-octyl-5-oxotetrahydrofuran-3...)
Affinity DataIC50:  5.90E+4nMAssay Description:Inhibition of human recombinant FASN thioesterase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Gallus gallus (Chicken))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50148911((3beta)-3-hydroxyurs-12-en-28-oic acid | 3beta-hyd...)
Affinity DataIC50:  5.93E+4nMAssay Description:Inhibition of chicken liver FASN ketoreductase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Gallus gallus (Chicken))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50153015((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
Affinity DataIC50:  6.80E+4nMAssay Description:Inhibition of chicken liver FASN ketoreductase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Gallus gallus (Chicken))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394663(CHEMBL2165267)
Affinity DataIC50:  8.00E+4nMAssay Description:Inhibition of chicken liver FASN ketoreductase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Gallus gallus (Chicken))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50256128((2R,3S)-4-methylene-2-octyl-5-oxotetrahydrofuran-3...)
Affinity DataIC50:  8.00E+4nMAssay Description:Inhibition of chicken liver FASN ketoreductase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394665(CHEMBL251750)
Affinity DataIC50:  9.68E+4nMAssay Description:Inhibition of FASN in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Gallus gallus (Chicken))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50070942((-)-Epigallocatechin gallate | (-)-Epigallocatechi...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of chicken liver FASN ketoreductase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394658(CHEMBL2165411)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ACC1 using acetyl coA as substrate and [14C]NaHCO3 incubated for 5 mins prior to substrate addition by liquid scintillation count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394662(CHEMBL1093743)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of FASN in human SKBR3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394666(CHEMBL248705)
Affinity DataIC50:  2.08E+5nMAssay Description:Inhibition of FASN in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50241313((5R)-4-hydroxy-3,5-dimethyl-5-[(1E)-2-methylbuta-1...)
Affinity DataIC50: >3.80E+5nMAssay Description:Inhibition of FASN in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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