Compile Data Set for Download or QSAR
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Found 59 Enz. Inhib. hit(s) with all data for entry = 50034351
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361010(CHEMBL1935572)
Affinity DataKi:  3nMAssay Description:Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361035(CHEMBL1935571)
Affinity DataKi:  4nMAssay Description:Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361010(CHEMBL1935572)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361015(CHEMBL592379)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361011(CHEMBL1935573)
Affinity DataKi:  5nMAssay Description:Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361011(CHEMBL1935573)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM26396(2,4-diamino-5,6-disubstituted pyrimidine, 10 | 6-[...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50191289(7-chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361035(CHEMBL1935571)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361014(CHEMBL260549 | VUF-10214)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361013(CHEMBL1935450)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)
Affinity DataKi:  6nMAssay Description:Binding affinity to rat histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)
Affinity DataKi:  6nMAssay Description:Binding affinity to human histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361012(CHEMBL1935574)
Affinity DataKi:  7nMAssay Description:Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM7966(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361034(CHEMBL1935570)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361012(CHEMBL1935574)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361029(CHEMBL1935565)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361030(CHEMBL1935566)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Mus musculus (mouse))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361012(CHEMBL1935574)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]histamine from mouse H4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361028(CHEMBL1935564)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50179335((5-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperaz...)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361032(CHEMBL1935568)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361016(CHEMBL501882 | US8796297, 13)
Affinity DataKi:  31nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361018(CHEMBL281590)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361021(CHEMBL1935557)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361033(CHEMBL1935569)
Affinity DataKi:  55nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361010(CHEMBL1935572)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]histamine from human H3 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataKi:  63nMAssay Description:Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataKi:  79nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361031(CHEMBL1935567)
Affinity DataKi:  90nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361019(CHEMBL1935555)
Affinity DataKi:  91nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361011(CHEMBL1935573)
Affinity DataKi:  98nMAssay Description:Displacement of [3H]histamine from human H3 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361026(CHEMBL1935562)
Affinity DataKi:  109nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361020(CHEMBL1935556)
Affinity DataKi:  111nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361012(CHEMBL1935574)
Affinity DataKi:  174nMAssay Description:Displacement of [3H]histamine from rat H4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361035(CHEMBL1935571)
Affinity DataKi:  188nMAssay Description:Displacement of [3H]histamine from human H3 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361022(CHEMBL1935558)
Affinity DataKi:  221nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50257496(4-(4-methylpiperazin-1-yl)quinazoline | CHEMBL5069...)
Affinity DataKi:  328nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361027(CHEMBL1935563)
Affinity DataKi:  649nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361025(CHEMBL1935561)
Affinity DataKi:  676nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361024(CHEMBL1935560)
Affinity DataKi:  945nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Mus musculus)
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361012(CHEMBL1935574)
Affinity DataKi:  1.07E+3nMAssay Description:Displacement of [3H]histamine from mouse H3RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361023(CHEMBL1935559)
Affinity DataKi:  2.33E+3nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361012(CHEMBL1935574)
Affinity DataKi:  2.56E+3nMAssay Description:Displacement of [3H]histamine from rat H3RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361010(CHEMBL1935572)
Affinity DataKi:  2.80E+3nMAssay Description:Displacement of [3H]histamine from human H1 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Mus musculus (mouse))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361012(CHEMBL1935574)
Affinity DataKi:  3.30E+3nMAssay Description:Displacement of [3H]histamine from mouse H1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361012(CHEMBL1935574)
Affinity DataKi:  3.41E+3nMAssay Description:Displacement of [3H]histamine from human H3 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361012(CHEMBL1935574)
Affinity DataKi:  3.60E+3nMAssay Description:Displacement of [3H]histamine from rat H1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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