Compile Data Set for Download or QSAR
maximum 50k data
Found 8 Enz. Inhib. hit(s) with all data for entry = 50043106
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50436124(CHEMBL2397474)
Affinity DataIC50:  32nMAssay Description:Inhibition of macrophage ACAT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 2(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50263192(CHEMBL478858 | CHEMBL564483 | Pactimibe | [7-(2,2-...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of macrophage ACAT2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 2(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50232478(CHEMBL403233)
Affinity DataIC50:  4.80E+3nMAssay Description:Non-competitive inhibition of human microsomal ACAT2 overexpressed in CHO cells using [14C]oleoyl-CoA as substrate assessed as formation of cholester...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50263192(CHEMBL478858 | CHEMBL564483 | Pactimibe | [7-(2,2-...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of ACAT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50232478(CHEMBL403233)
Affinity DataIC50:  6.20E+3nMAssay Description:Non-competitive inhibition of human microsomal ACAT1 overexpressed in CHO cells using [14C]oleoyl-CoA as substrate assessed as formation of cholester...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50232478(CHEMBL403233)
Affinity DataIC50:  6.40E+3nMAssay Description:Non-competitive inhibition of microsomal ACAT in human MDM using [14C]oleoyl-CoA as substrate assessed as formation of cholesteryl [14C]-oleate after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 2(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50069900(2,6-diisopropylphenyl 2-(2,4,6-triisopropylphenyl)...)
Affinity DataIC50:  9.20E+3nMAssay Description:Inhibition of ACAT2 in human MDM assessed as inhibition of acetylated LDL-induced cholesterol ester accumulation after 1 hr by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50069900(2,6-diisopropylphenyl 2-(2,4,6-triisopropylphenyl)...)
Affinity DataIC50:  2.35E+4nMAssay Description:Inhibition of ACAT1 in human MDM assessed as inhibition of acetylated LDL-induced cholesterol ester accumulation after 1 hr by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed