Found 49 Enz. Inhib. hit(s) with all data for entry = 50043183 
Affinity DataIC50: 11nMAssay Description:Inhibition of aurora-B (unknown origin) autophosphorylationMore data for this Ligand-Target Pair
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of RON (unknown origin) autophosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of ALK (unknown origin) autophosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 70nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 86nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 89nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 92nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of short-form RON (unknown origin) expressed in human HeLa cells assessed as phosphorylated RON levels after 4 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of short-form RON (unknown origin) expressed in human HeLa cells assessed as phosphorylated RON levels after 4 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 360nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of ALK autophosphorylation in human Karpas-299 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 520nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 560nMAssay Description:Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 560nMAssay Description:Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 580nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 590nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 590nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs in presence of mouse plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 660nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 780nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 950nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of aurora-B in human HT-29 cells assessed as phosphorylation of histone H3 at Ser10More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of aurora-B in human HT-29 cells assessed as phosphorylation of histone H3 at Ser10 in presence of mouse plasmaMore data for this Ligand-Target Pair
