Found 32 Enz. Inhib. hit(s) with all data for entry = 50043730 TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-3(Rattus norvegicus)
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 0.260nMAssay Description:Inhibition of rat alpha6/alpha3beta2beta3 nAChR expressed in Xenopus oocytes assessed as inhibition of ACh-induced current by voltage clamp electroph...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-2/beta-3(Homo sapiens (Human))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 0.950nMAssay Description:Antagonist activity at human alpha6/alpha3beta2beta3 nAChR expressed in Xenopus oocytes assessed as inhibition of ACh-induced current by voltage clam...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Homo sapiens (Human))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at human alpha3beta2 nAChR expressed in Xenopus oocytes assessed as inhibition of ACh-induced current by voltage clamp electrophy...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Rattus norvegicus (Rat))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of rat alpha6/alpha3beta4 nAChR expressed in Xenopus oocytes assessed as inhibition of ACh-induced current by voltage clamp electrophysiol...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Homo sapiens (Human))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 5.20nMAssay Description:Inhibition of alpha9alpha10 (unknown origin) nAChRMore data for this Ligand-Target Pair
Affinity DataIC50: 6.90nMAssay Description:Inhibition of recombinant rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current by voltage clamp ...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of rat alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current after 2 to 4 days by voltage cl...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Antagonist activity at Sprague-Dawley rat alpha9alpha10 nAChR expressed in Xenopus oocytes assessed as inhibition of ACh-induced current by voltage c...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-3(Rattus norvegicus)
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of rat alpha6/alpha3beta2beta3 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current by voltage clamp el...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of rat alpha3beta4 nAChR expressed in Xenopus oocytes assessed as inhibition of ACh-induced current by voltage clamp electrophysiology met...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Homo sapiens (Human))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Antagonist activity at human alpha6alpha3beta4 nAChR expressed in Xenopus oocytes assessed as inhibition of ACh-induced current by voltage clamp elec...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Homo sapiens (Human))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of alpha3beta2 nAChR (unknown origin) expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Homo sapiens (Human))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of human alpha3beta2 nAChRMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Homo sapiens (Human))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 74nMAssay Description:Antagonist activity at human alpha3beta2 nAChR expressed in Xenopus oocytes assessed as inhibition of ACh-induced current by voltage clamp electrophy...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Rattus norvegicus (Rat))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 94nMAssay Description:Inhibition of rat alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current after 2 to 4 days by vol...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 97nMAssay Description:Inhibition of alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 103nMAssay Description:Inhibition of alpha7 nAChR (unknown origin) expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-3(Rattus norvegicus)
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Antagonist activity at Sprague-Dawley rat alpha6/alpha3beta2beta3 nAChR expressed in Xenopus oocytes assessed as inhibition of ACh-induced current by...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 309nMAssay Description:Antagonist activity at human alpha4beta2 nAChR expressed in Xenopus oocytes assessed as inhibition of ACh-induced current by voltage clamp electrophy...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 480nMAssay Description:Inhibition of recombinant rat alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current by voltage clamp el...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 518nMAssay Description:Antagonist activity at human alpha3beta4 nAChR expressed in Xenopus oocytes assessed as inhibition of ACh-induced current by voltage clamp electrophy...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 595nMAssay Description:Inhibition of human alpha7 nAChRMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 750nMAssay Description:Inhibition of rat alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current after 2 to 4 days by voltage cl...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 755nMAssay Description:Antagonist activity at human alpha3beta4 nAChR expressed in Xenopus oocytes assessed as inhibition of ACh-induced current by voltage clamp electrophy...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Rattus norvegicus (Rat))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 980nMAssay Description:Antagonist activity at Sprague-Dawley rat alpha6/alpha3beta4 nAChR expressed in Xenopus oocytes assessed as inhibition of ACh-induced current by volt...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Homo sapiens (Human))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human alpha9alpha10 nAChRMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 3.39E+3nMAssay Description:Inhibition of human alpha3beta4 nAChRMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 4.20E+3nMAssay Description:Antagonist activity at Sprague-Dawley rat alpha3beta4 nAChR expressed in Xenopus oocytes assessed as inhibition of ACh-induced current by voltage cla...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of alpha7 (unknown origin) nAChRMore data for this Ligand-Target Pair
TargetAcetylcholine receptor subunit alpha/beta/delta/epsilon(MOUSE)
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse alpha1beta1deltaepsilon nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current after 2 to 4 days...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current after 2 to 4 days by voltage ...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-3(Rattus norvegicus)
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of rat alpha6/alpha3beta2beta3 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current after 2 to 4 days b...More data for this Ligand-Target Pair
